1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Dipeptidyl Peptidase

Dipeptidyl Peptidase

Dipeptidyl Peptidase (DPP) is an antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation,signal transduction and apoptosis. DPP is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPP are proline-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPP plays a major role in glucose metabolism. DPP is responsible for the degradation of incretins such as GLP-1. Furthermore, DPP appears to work as a suppressor in the development of cancer and tumours. DPP plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others.

Dipeptidyl Peptidase 相关产品 (36):

Cat. No. Product Name Effect Purity
  • HY-13233A
    Talabostat mesylate Inhibitor >98.0%
    Talabostat mesylate (Val-boroPro mesylate; PT100 mesylate) 是一种口服活性和非选择性的二肽基肽酶 IV (DPP-IV) 抑制剂 (IC50 < 4 nM; Ki = 0.18 nM) 和成纤维细胞活化蛋白 (FAP) 的第一个临床抑制剂 (IC50 = 560 nM),抑制 DPP8/9 (IC50 = 4/11 nM; Ki = 1.5/0.76 nM),静息细胞脯氨酸二肽酶 (QPP) (IC50 = 310 nM)、DPP2 和一些其他 DASH 家族酶。具有抗肿瘤和造血刺激活性 。
  • HY-15695
    Puromycin aminonucleoside Inhibitor 99.59%
    Puromycin aminonucleoside (NSC 3056) 是一种氨基核苷类抗生素,为嘌呤霉素类似物。Puromycin aminonucleoside 诱导细胞凋亡 (apoptosis)。Puromycin aminonucleoside 可逆抑制二肽基肽酶 (dipeptidyl peptidase II) 和胞浆丙氨酸氨基肽酶。
  • HY-13749
    Sitagliptin Inhibitor 99.72%
    Sitagliptin (MK-0431) 是一种有效的 DPP4 抑制剂,在 Caco-2 细胞中,IC50 值为 19 nM。
  • HY-14291
    Vildagliptin Inhibitor 98.18%
    Vildagliptin (LAF237) 是一种有效且稳定的选择性二肽基肽酶IV (DPP-IV) 抑制剂,在人 Caco-2 细胞中抑制 DPP-IV 的 IC50 为 3.5 nM。Vildagliptin 具有出色的口服生物利用度和有效的降血糖活性。
  • HY-101056
    Brensocatib Inhibitor 99.66%
    Brensocatib (AZD7986) 是一个二肽基肽酶 1 (DPP1) 抑制剂,在人,小鼠,大鼠,狗和兔中的 pIC50 值分别为 6.85, 7.6, 7.7, 7.8 和 7.8。
  • HY-14892A
    Gemigliptin tartrate Inhibitor 98.28%
    Gemigliptin tartrate (LC15-0444 tartrate) 是一种高度选择性的,可逆的,竞争性的二肽基肽酶 4 (DPP-4) 抑制剂,对人重组 DPP-4 作用的 IC50 值为 10.3 nM。Gemigliptin tartrate 具有很强的抗糖基化特性。Gemigliptin tartrate 可用于晚期糖基化终产物 (AGE) 相关的糖尿病并发症的研究。
  • HY-N7653
    Azaleatin Inhibitor
    Azaleatin 是一种从 Rhododendron 种中分离得到的 O-甲基化黄酮醇。Azaleatin 是二肽基肽酶-IV 的抑制剂。Azaleatin 可用于 2 型糖尿病和肥胖症的研究。
  • HY-111174
    Diprotin A Inhibitor
    Diprotin A (Ile-Pro-Ile) 是二肽基肽酶 IV (DPP-IV) 的抑制剂。
  • HY-13749B
    Sitagliptin phosphate monohydrate Inhibitor 99.78%
    Sitagliptin (MK0431 phosphate monohydrate) 是一种有效的 DPP4 抑制剂,在 Caco-2 细胞中,IC50 值为 19 nM。
  • HY-10284
    Linagliptin Inhibitor 99.97%
    Linagliptin 是一种有效,选择性的 DPP-4 抑制剂,IC50 值为 1 nM。
  • HY-10285
    Saxagliptin Inhibitor 99.61%
    Saxagliptin (BMS-477118) 是一种有效,选择性,可逆,竞争性和具有口服活性的二肽基肽酶 4 (DPP-4) (Ki = 0.6-1.3 nM) 抑制剂。Saxagliptin 可用于 2 型糖尿病的研究。
  • HY-14806
    Teneligliptin Inhibitor 99.57%
    Teneligliptin (MP-513) 是一种有效的、口服的、有竞争力的、持久的 DPP-4 抑制剂。Teneligliptin 在体外对人血浆、大鼠血浆和人重组 DPP-4 有竞争性抑制作用,其 IC50s,约 1 nM。
  • HY-14877
    Anagliptin Inhibitor
    Anagliptin 是一种高选择性的,有效的二肽酰肽酶 4 (DPP-4) 抑制剂,IC50 值为 3.8 nM,对 DPP-8/9 的选择性相对较弱,IC50 值分别为 68 和 60 nM。
  • HY-15981
    Omarigliptin Inhibitor
  • HY-A0023
    Alogliptin Benzoate Inhibitor 99.96%
    Alogliptin Benzoate (SYR-322) 是一种有效的、具有选择性口服活性的 DPP-4 的抑制剂,IC50 值小于 10 nM,比对 DPP-8 和 DPP-9 的抑制性高 10000 倍以上。Alogliptin Benzoate 可用于研究 2 型糖尿病。
  • HY-111174A
    Diprotin A TFA Inhibitor 98.80%
    Diprotin A TFA (Ile-Pro-Ile TFA) 是二肽基肽酶 IV (DPP-IV) 的抑制剂。
  • HY-15408
    Trelagliptin Inhibitor 99.80%
  • HY-10287
    Gosogliptin Inhibitor 99.27%
    Gosogliptin 是一种有效的选择性二肽基肽酶IV (DPP-IV) 抑制剂。
  • HY-15408A
    Trelagliptin succinate Inhibitor 99.89%
    Trelagliptin succinate (SYR-472 succinate) 是长效的DPP-4抑制剂。
  • HY-112668
    Retagliptin Phosphate Inhibitor 99.70%
    Retagliptin Phosphate 是 DPP-4 的抑制剂,可用于 2 型糖尿病的研究。
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