1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Dipeptidyl Peptidase

Dipeptidyl Peptidase

Dipeptidyl Peptidase (DPP) is an antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation,signal transduction and apoptosis. DPP is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPP are proline-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPP plays a major role in glucose metabolism. DPP is responsible for the degradation of incretins such as GLP-1. Furthermore, DPP appears to work as a suppressor in the development of cancer and tumours. DPP plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others.

Dipeptidyl Peptidase 相关产品 (40):

Cat. No. Product Name Effect Purity
  • HY-13233A
    Talabostat mesylate Inhibitor >98.0%
    Talabostat mesylate (Val-boroPro mesylate; PT100 mesylate) 是一种口服活性和非选择性的二肽基肽酶 IV (DPP-IV) 抑制剂 (IC50 < 4 nM; Ki = 0.18 nM) 和成纤维细胞活化蛋白 (FAP) 的第一个临床抑制剂 (IC50 = 560 nM),抑制 DPP8/9 (IC50 = 4/11 nM; Ki = 1.5/0.76 nM),静息细胞脯氨酸二肽酶 (QPP) (IC50 = 310 nM)、DPP2 和一些其他 DASH 家族酶。具有抗肿瘤和造血刺激活性 。
  • HY-13749
    Sitagliptin Inhibitor 99.72%
    Sitagliptin 是一种有效的 DPP4 抑制剂,在 Caco-2 细胞中,IC50 值为 19 nM。
  • HY-15695
    Puromycin aminonucleoside Inhibitor 99.59%
    Puromycin aminonucleoside (NSC 3056) 是一种氨基核苷类抗生素,为嘌呤霉素类似物。Puromycin aminonucleoside 诱导细胞凋亡 (apoptosis)。Puromycin aminonucleoside 可逆抑制二肽基肽酶 (dipeptidyl peptidase II) 和胞浆丙氨酸氨基肽酶。
  • HY-14291
    Vildagliptin Inhibitor 98.03%
    Vildagliptin (LAF237) 是一种有效且稳定的选择性二肽基肽酶IV (DPP-IV) 抑制剂,在人 Caco-2 细胞中抑制 DPP-IV 的 IC50 为 3.5 nM。Vildagliptin 具有出色的口服生物利用度和有效的降血糖活性。
  • HY-101056
    AZD7986 Inhibitor 99.07%
    AZD7986 是一个二肽基肽酶 1 (DPP1) 抑制剂,在人,小鼠,大鼠,狗和兔中的 pIC50 值分别为 6.85, 7.6, 7.7, 7.8 和 7.8。
  • HY-116304
    1G244 Inhibitor >98.0%
    1G244 是一种有效的 DPP8/9 抑制剂,IC50 分别为 12 nM 和 84 nM,但不抑制 DPPIV 和 DPPII。1G244 可诱导多发性骨髓瘤细胞凋亡,并具有抗骨髓瘤作用。
  • HY-117985B
    Evogliptin tartrate Inhibitor
    Evogliptin tartrate 是一种高效、口服有效、选择性的 DPP-4 抑制剂,具有抗糖尿病活性。Evogliptin tartrate 具有靶向动脉炎症治疗动脉粥样硬化的潜力。
  • HY-10286A
    Dutogliptin tartrate Inhibitor
    Dutogliptin tartrate (PHX-1149) 是一种口服有效的选择性二肽基肽酶-4 (DPP4) 抑制剂,可用于治疗 2 型糖尿病。
  • HY-13749B
    Sitagliptin phosphate monohydrate Inhibitor 99.78%
    Sitagliptin(MK 0431)是DPP4高效抑制剂,在Caco-2细胞中IC50值为19nM。
  • HY-10284
    Linagliptin Inhibitor 99.97%
    Linagliptin 是一种有效,选择性的 DPP-4 抑制剂,IC50 值为 1 nM。
  • HY-10285
    Saxagliptin Inhibitor 99.61%
    Saxagliptin是一种口服活性的二肽基肽酶-4 (DPP4)抑制剂,有助于控制血糖水平。
  • HY-14806
    Teneligliptin Inhibitor 99.57%
    Teneligliptin (MP-513) 是一种有效的、口服的、有竞争力的、持久的 DPP-4 抑制剂。Teneligliptin 在体外对人血浆、大鼠血浆和人重组 DPP-4 有竞争性抑制作用,其 IC50s,约 1 nM。
  • HY-14892
    Gemigliptin Inhibitor 98.10%
    Gemigliptin是高度选择性的二肽基肽酶4 (dipeptidyl peptidase 4 (DPP4)) 抑制剂。
  • HY-15981
    Omarigliptin Inhibitor 99.88%
    Omarigliptin(MK-3102)是DPP4高效选择性抑制剂,IC50值为1.6nM。
  • HY-14877
    Anagliptin Inhibitor 99.72%
    Anagliptin 是一种高选择性的,有效的二肽酰肽酶 4 (DPP-4) 抑制剂,IC50 值为 3.8 nM,对 DPP-8/9 的选择性相对较弱,IC50 值分别为 68 和 60 nM。
  • HY-15408
    Trelagliptin Inhibitor 99.89%
    Trelagliptin(SYR-472)是长效的DPP4抑制剂,可作用于2型糖尿病。
  • HY-111174A
    Diprotin A TFA Inhibitor 98.80%
    Diprotin A (TFA) 是二肽基肽酶 IV (DPP-IV) 的抑制剂。
  • HY-A0023
    Alogliptin Benzoate Inhibitor 99.96%
    Alogliptin benzoate(SYR 322)是高活性DPP-4抑制剂,IC50<10 nM,比对DPP-8和DPP-9的抑制性高10000倍。
  • HY-15408A
    Trelagliptin succinate Inhibitor 99.89%
    Trelagliptin succinate (SYR-472 succinate) 是长效的DPP-4抑制剂。
  • HY-14806A
    Teneligliptin hydrobromide Inhibitor 99.99%
    Teneligliptin hydrobromide (MP-513 hydrobromide) 是一种抗高血压剂,为 β2 肾上腺素能受体 (β2AR) 阻滞剂,具有抗氧化、清除自由基的活性。
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