1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Enolase

Enolase (烯醇化酶)

Phosphopyruvate hydratase

Enolase (phosphopyruvate hydratase) is a metalloenzyme responsible for the catalysis of the conversion of 2-phosphoglycerate (2-PG) tophosphoenolpyruvate (PEP), the ninth and penultimate step of glycolysis. Enolase belongs to the class Lyase. Enolase can also catalyze the reverse reaction, depending on environmental concentrations of substrates. The optimum pH for this enzyme is 6.5. Enolase is present in all tissues and organisms capable of glycolysis or fermentation. Small-molecule inhibitors of enolase have been synthesized as chemical probes of the catalytic mechanism of the enzyme. The most potent of inhibitors is phosphonoacetohydroxamate, which in its unprotonated form has pM affinity for the enzyme. It has structural similarity to the presumed catalytic intermediate, between PEP and 2-PG. Attempts have been made to use this inhibitor as an anti-trypanosome drug, and more recently, as an anti-cancer agent.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-15858
    AP-III-a4 Inhibitor 98.65%
    AP-III-a4 (ENOblock) 是一种非底物类似物烯醇酶(enolase)抑制剂,IC50 为 0.576 uM。 AP-III-a4 可用于癌症和糖尿病研究。
    AP-III-a4
  • HY-141412
    D-(-)-3-Phosphoglyceric acid disodium Inhibitor ≥98.0%
    D-(-)-3-Phosphoglyceric acid (3-Phospho-D-glyceric acid) disodium 是酶催化糖酵解过程中的重要中间体。D-(-)-3-Phosphoglyceric acid disodium 竞争性抑制酵母烯醇化酶 (enolase)。
    D-(-)-3-Phosphoglyceric acid disodium
  • HY-131904
    POMHEX Inhibitor 99.77%
    POMHEX 是一个消旋混合物,是具有细胞渗透性的 HEX 的 POM 前体活性分子,是 ENO2 的特异性抑制剂。POMHEX 对 ENO1 缺失的细胞表现出低纳摩尔级别活性,并对 ENO1 缺失的肿瘤模型表现出良好的抗癌效果。POMHEX 是有效的糖酵解抑制剂。
    POMHEX
  • HY-15858A
    AP-III-a4 hydrochloride Inhibitor 98.77%
    AP-III-a4 (ENOblock) hydrochloride 是一种非底物类似物烯醇酶 (enolase) 抑制剂,IC50 为 0.576 uM。 AP-III-a4 hydrochloride 可用于癌症和糖尿病研究。
    AP-III-a4 hydrochloride
  • HY-117778
    SF2312 Inhibitor
    SF2312 是一种天然膦酸盐抗生素 (antibiotic),是一种高效的烯醇化酶 (enolase) (Enolase) 抑制剂,对人重组 ENO1ENO2IC50 值分别为 37.9 nM 和 42.5 nM。SF2312 在厌氧条件下对细菌具有活性。
    SF2312
  • HY-131904A
    Hex Inhibitor 99.96%
    Hex 是烯醇酶 (enolase) 的抑制剂,其对 ENO2 和 ENO1 的 Ki 值分别为 74.4 nM 和 269.4 nM。
    Hex
  • HY-117778B
    SF2312 ammonium Inhibitor ≥98.0%
    SF2312 ammonium 是 SF2312 的铵形式。SF2312 是一种膦酸盐抗生素和烯醇酶抑制剂。SF2312 可以从放线菌小单孢菌中分离出来,它在厌氧条件下具有活性。SF2312 对 ENO1 缺失的神经胶质瘤细胞具有选择性毒性。
    SF2312 ammonium
目录号 产品名 / 同用名 应用 反应物种