1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. FABP

FABP (脂肪酸结合蛋白)

Fatty acid-binding proteins (FABPs) are members of the intracellular lipid-binding protein (iLBP) family and are involved in reversibly binding intracellular hydrophobic ligands and trafficking them throughout cellular compartments, including the peroxisomes, mitochondria, endoplasmic reticulum and nucleus. FABPs have broad specificity, including the ability to bind long-chain (C16-C20) fatty acids, eicosanoids, bile salts and peroxisome proliferators. FABPs demonstrate strong evolutionary conservation and are present in a spectrum of species including Drosophila melanogaster, Caenorhabditis elegans, mouse and human.

FABPs are widely expressed throughout the body and play an integral role in a multitude of physiological processes such as lipid metabolism, inflammation and neuronal signaling. FABPs of the mammalian central and peripheral nervous systems have been shown to facilitate the intracellular transport of NAEs, particularly the endocannabinoid arachidonoyl ethanolamide (anandamide, AEA), as well as catabolism by the endoplasmic reticulum-localized enzyme fatty acid amide hydrolase (FAAH).

Most mammals produce 12 distinct subtypes of FABPs, although humans produce up to 10. These include liver-(L-FABP, FABP1), intestine-(I-FABP, FABP2), heart-(H-FABP, FABP3), adipocyte-(A-FABP, FABP4), epidermal-(E-FABP, FABP5), ileal-(Il-FABP, FABP6), brain-(B-FABP, FABP7), myelin-(M-FABP, FABP8), testis-(T-FABP, FABP9) and FABP12, and three of which are expressed in the brain, including FABP3, FABP5 and FABP7.

FABPs have diverse and highly specified roles in regulating the metabolism and actions of the ligands they bind. They are important targets for drug development and therapy for many metabolic diseases.

FABP 相关产品 (5):

目录号 产品名 作用方式 纯度
  • HY-101903
    BMS-309403 Inhibitor ≥98.0%
    BMS-309403 是一种有效的选择性脂肪细胞脂肪酸结合蛋白 aFABP,也称作 FABP4aP2,抑制剂,对 FABP4,FABP3 和 FABP5 的 Ki 分别为 <2 nM,250 nM,350 nM。BMS-309403 与蛋白质内部的脂肪酸结合口袋相互作用,竞争性地抑制内源性脂肪酸的结合。BMS-309403 可改善载脂蛋白E缺乏症小鼠和培养的人内皮细胞的内皮功能。
  • HY-101903A
    BMS-309403 sodium Inhibitor 98.73%
    BMS-309403 sodium 是一种有效的选择性脂肪细胞脂肪酸结合蛋白 aFABP, 也称为 FABP4,aP2 抑制剂,对 FABP4,FABP3 和 FABP5 的 Ki 分别为 <2 nM,250 nM,350 nM。BMS-309403 sodium 与蛋白质内部的脂肪酸结合口袋相互作用,竞争性地抑制内源性脂肪酸的结合。BMS-309403 sodium 可改善载脂蛋白E缺乏症小鼠和培养的人内皮细胞的内皮功能。
  • HY-129910
    FABP5-IN-1 Inhibitor 98.57%
    FABP5-IN-1 是一种选择性,高亲和力脂肪酸结合蛋白 5 (FABP5) 抑制剂,Ki 值为 1.7 μM。FABP5-IN-1 与 FABP3 和 FABP7 均不结合,并具有有效的镇痛作用。
  • HY-101503
    HTS01037 Antagonist 99.76%
    HTS01037是结合脂肪酸的抑制剂。它也是由AFABP / aP2介导的蛋白质-蛋白质相互作用的拮抗剂,Ki值为0.67 μM。
  • HY-129911
    FABP-IN-1 Inhibitor 98.20%
    FABP-IN-1(Compounds 4b) 是一种高亲和力脂肪酸结合蛋白 (FABP) 抑制剂。FABP-IN-1 抑制 FABP3FABP5FABP7Ki 值分别为 0.69 μM,0.55 μM 和 0.67 μM,并具有有效的镇痛作用。
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