1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. FABP

FABP (脂肪酸结合蛋白)

Fatty acid-binding protein

Fatty acid-binding proteins (FABPs) are members of the intracellular lipid-binding protein (iLBP) family and are involved in reversibly binding intracellular hydrophobic ligands and trafficking them throughout cellular compartments, including the peroxisomes, mitochondria, endoplasmic reticulum and nucleus. FABPs have broad specificity, including the ability to bind long-chain (C16-C20) fatty acids, eicosanoids, bile salts and peroxisome proliferators. FABPs demonstrate strong evolutionary conservation and are present in a spectrum of species including Drosophila melanogaster, Caenorhabditis elegans, mouse and human.

FABPs are widely expressed throughout the body and play an integral role in a multitude of physiological processes such as lipid metabolism, inflammation and neuronal signaling. FABPs of the mammalian central and peripheral nervous systems have been shown to facilitate the intracellular transport of NAEs, particularly the endocannabinoid arachidonoyl ethanolamide (anandamide, AEA), as well as catabolism by the endoplasmic reticulum-localized enzyme fatty acid amide hydrolase (FAAH).

Most mammals produce 12 distinct subtypes of FABPs, although humans produce up to 10. These include liver-(L-FABP, FABP1), intestine-(I-FABP, FABP2), heart-(H-FABP, FABP3), adipocyte-(A-FABP, FABP4), epidermal-(E-FABP, FABP5), ileal-(Il-FABP, FABP6), brain-(B-FABP, FABP7), myelin-(M-FABP, FABP8), testis-(T-FABP, FABP9) and FABP12, and three of which are expressed in the brain, including FABP3, FABP5 and FABP7.

FABPs have diverse and highly specified roles in regulating the metabolism and actions of the ligands they bind. They are important targets for drug development and therapy for many metabolic diseases.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-101903
    BMS-309403 Inhibitor 99.91%
    BMS-309403 是一种有效的选择性脂肪细胞脂肪酸结合蛋白 aFABP,也称作 FABP4aP2,抑制剂,对 FABP4,FABP3 和 FABP5 的 Ki 分别为 <2 nM,250 nM,350 nM。BMS-309403 与蛋白质内部的脂肪酸结合口袋相互作用,竞争性地抑制内源性脂肪酸的结合。BMS-309403 可改善载脂蛋白E缺乏症小鼠和培养的人内皮细胞的内皮功能。
  • HY-101903A
    BMS-309403 sodium Inhibitor 99.94%
    BMS-309403 sodium 是一种有效的选择性脂肪细胞脂肪酸结合蛋白 aFABP, 也称为 FABP4,aP2 抑制剂,对 FABP4,FABP3 和 FABP5 的 Ki 分别为 <2 nM,250 nM,350 nM。BMS-309403 sodium 与蛋白质内部的脂肪酸结合口袋相互作用,竞争性地抑制内源性脂肪酸的结合。BMS-309403 sodium 可改善载脂蛋白E缺乏症小鼠和培养的人内皮细胞的内皮功能。
    BMS-309403 sodium
  • HY-145990
    FABPs ligand 6 Inhibitor 98.57%
    FABPs ligand 6 (MF6) 是一种 FABP5FABP7 抑制剂,KD 值分别为 874 nM 和 20 nM。FABPs ligand 6 可用于多发性硬化症的研究。
    FABPs ligand 6
  • HY-101503
    HTS01037 Antagonist 99.84%
    HTS01037是结合脂肪酸的抑制剂。它也是由AFABP / aP2介导的蛋白质-蛋白质相互作用的拮抗剂,Ki值为0.67 μM。
  • HY-148665
    FABP-IN-2 Inhibitor
    FABP-IN-2 是一种新型的 FABP3 配体。FABP-IN-2 抑制 FABP3/FABP4 的 IC50 分别为 1.16 μM 和 4.27 μM。
  • HY-160457
    FABP4/5-IN-5 Inhibitor
    FABP4/5-IN-4 (compound E1) 是 FABP4 和 FABP5 的有效抑制剂,IC50s 值分别为 4.68 μM 和 10.72 μM。FABP4/5-IN-4在糖尿病等代谢紊乱中发挥重要作用。
  • HY-117562
    a-FABP-IN-1 Inhibitor
    a-FABP-IN-1 (Compound 5g) 是一种有效的、选择性的人脂肪细胞脂肪酸结合蛋白 (a-FABP) 抑制剂,其 Ki 小于 1.0 nM。a-FABP-IN-1 抑制促炎细胞因子的产生。
  • HY-160456
    FABP4/5-IN-4 Inhibitor
    FABP4/5-IN-4 (compound E1) 是 FABP4 和 FABP5 的有效抑制剂,IC50s 值分别为 3.78 μM 和 5.72 μM。FABP4/5-IN-4 在糖尿病等代谢紊乱中发挥重要作用。
  • HY-P4115
    CooP 是一种线性胶质母细胞瘤靶向九肽。CooP 与胶质母细胞瘤细胞及其相关脉管系统中的乳腺来源生长抑制剂/脂肪酸结合蛋白 3 (FABP3) 结合。CooP 用于靶向递送化学疗法和不同的纳米粒子。
  • HY-149953
    FABP4-IN-2 Inhibitor
    FABP4-IN-2 (Compd 10g) 是一种选择性的、具有口服活性的 FABP4 抑制剂,作用于 FABP4 的 Ki 值为 0.51 μM,作用于 FABP3 的 Ki 值为 33.01 μM。FABP4-IN-2 可用于炎症相关疾病研究。
  • HY-163032
    FABP4-IN-3 Inhibitor
    FABP4-IN-3 (化合物 C3) 是一种高选择性的 FABP4 抑制剂 (FABP4 Ki = 25 ± 3a nM, FABP3 Ki = 15.03 μM),其选择性是 FABP3 的 601 倍。FABP4-IN-3 还具有代谢稳定性和强大的细胞抗炎活性,有望参与代谢性疾病、心功能障碍和炎症相关疾病的研究。
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