1. Signaling Pathways
  2. GPCR/G Protein
  3. GNRH Receptor

GNRH Receptor

GNRH Receptor (Gonadotropin-releasing hormone receptor, GNRHR), also known as the luteinizing hormone releasing hormone receptor (LHRHR), is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes,breast, ovary, and prostate. GNRH Receptor is a 60 kDa G protein-coupled receptor and resides primarily in the pituitary and is responsible for eliciting the actions of LHRH after its release from the hypothalamus. Upon activation, GNRH Receptor stimulates tyrosine phosphatase and elicits the release of LH from the pituitary. Following binding of Gonadotropin releasing hormone (GNRH), GNRH Receptor associates with G-proteins that activate a phosphatidylinositol (PtdIns)-calcium second messenger system. Activation of GNRHR ultimately causes the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH).

GNRH Receptor 相关产品 (16):

Cat. No. Product Name Effect Purity
  • HY-13665
    Leuprolide Acetate Agonist 99.88%
    Leuprolide Acetate (Leuprorelin acetate) 是一种促性腺激素释放激素 (GnRH) 类似物,能作为 GnRH 受体 (GnRH receptor) 激动剂。Leuprolide Acetate 可用于前列腺癌、子宫内膜异位症、子宫肌瘤、中枢性早熟、多发性硬化症的研究。Leuprolide Acetate 能改善大鼠模型中的实验性自身免疫性脑脊髓炎 (EAE)。
  • HY-16168A
    Degarelix Antagonist 99.92%
    Degarelix是一种竞争性,可逆的的促性腺激素释放激素受体 (GnRHR) 拮抗剂。
  • HY-13581A
    Buserelin Acetate Agonist 99.75%
    Buserelin Acetate是一个GnRH的激动剂。
  • HY-P0009A
    Cetrorelix Acetate Antagonist 99.69%
    Cetrorelix Acetate (SB-75 acetate) 是 GnRH 受体的强效拮抗剂,其 IC50 值为 1.21 nM。
  • HY-16474
    Relugolix Antagonist >98.0%
    Relugolix (TAK-385) 是一种有效的,具有口服活性,非肽性促性腺激素释放激素(GnRH) 的拮抗剂。与 TAK-013 (HY-100209 ) 相比,Relugolix 对人 (IC50=0.33 nM) 和猴子 (IC50=0.32 nM) 的受体具有高亲和力和强拮抗活性。Relugolix 用于性激素依赖性疾病的研究,如子宫内膜异位症、子宫肌瘤、前列腺癌等。
  • HY-P0009B
    Cetrorelix diacetate Antagonist
    Cetrorelix diacetate (SB-075 diacetate)是 GnRH 受体的强效拮抗剂,其 IC50 值为 1.21 nM。
  • HY-P1022
    Kisspeptin-54(human) (Metastin(human)) 是一种 Kisspeptin 受体 (KISS1GPR54) 的内源性配体,以高亲和力结合大鼠和人类 GPR54 受体,其 Ki 值分别为 1.81 nM 和 1.45 nM。Kisspeptin-54(human) 可抑制肿瘤转移并刺激促性腺激素分泌。
  • HY-P1022A
    Kisspeptin-54(human) TFA
    Kisspeptin-54(human) TFA (Metastin(human) TFA) 是一种 Kisspeptin 受体 (KISS1GPR54) 的内源性配体,以高亲和力结合大鼠和人类 GPR54 受体,其 Ki 值分别为 1.81 nM 和 1.45 nM。Kisspeptin-54(human) TFA 可抑制肿瘤转移并刺激促性腺激素分泌。
  • HY-14369
    Elagolix sodium Antagonist 99.66%
    Elagolix sodium 是一种人的 GnRH 受体 (GnRHR) 拮抗剂,其 IC50Ki 值分别为 0.25 和 3.7 nM。
  • HY-13673A
    Goserelin acetate Agonist 99.96%
    Goserelin acetate (ICI-118630 acetate) 是一种促性腺激素释放激素 (GnRH) 类似物,能作为 GnRH 激动剂。Goserelin acetate 可用于乳腺癌、上皮性卵巢癌和前列腺癌的研究。
  • HY-17405
    Alarelin Acetate Agonist 99.43%
    Alarelin acetate是合成的GnRH激动剂。
  • HY-14789
    (R)-Elagolix Antagonist 98.06%
    Elagolix是一种高度有效的, 选择性, 口服活性的, 短期的, 非肽类促性腺激素释放激素受体 (GnRH受体) 拮抗剂 (KD = 54 pM)。
  • HY-13534
    Abarelix Antagonist
    Abarelix (R3827) 是有效的促性腺激素释放激素 (GnRH) 拮抗剂,用于研究前列腺癌。
  • HY-13534A
    Abarelix Acetate Antagonist 99.62%
    Abarelix (R3827) Acetate 是有效的促性腺激素释放激素 (GnRH) 拮抗剂,用于研究前列腺癌。
  • HY-13673
    Goserelin Agonist
    Goserelin 是一种促性腺激素释放激素 (GnRH) 类似物,能作为 GnRH 激动剂。Goserelin 可用于乳腺癌、上皮性卵巢癌和前列腺癌的研究。
  • HY-133080
    BAY-784 Antagonist
    BAY-784 是一种促性腺激素释放激素受体 (GnRH-R) 拮抗剂探针,对人和大鼠 GnRH-RIC50 分别为 21 和 24 nM。
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