1. Signaling Pathways
  2. GPCR/G Protein
  3. GNRH Receptor

GNRH Receptor

GNRH Receptor (Gonadotropin-releasing hormone receptor, GNRHR), also known as the luteinizing hormone releasing hormone receptor (LHRHR), is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes,breast, ovary, and prostate. GNRH Receptor is a 60 kDa G protein-coupled receptor and resides primarily in the pituitary and is responsible for eliciting the actions of LHRH after its release from the hypothalamus. Upon activation, GNRH Receptor stimulates tyrosine phosphatase and elicits the release of LH from the pituitary. Following binding of Gonadotropin releasing hormone (GNRH), GNRH Receptor associates with G-proteins that activate a phosphatidylinositol (PtdIns)-calcium second messenger system. Activation of GNRHR ultimately causes the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH).

GNRH Receptor 相关产品 (17):

Cat. No. Product Name Effect Purity
  • HY-16168A
    Degarelix Antagonist 99.92%
    Degarelix是一种竞争性,可逆的的促性腺激素释放激素受体 (GnRHR) 拮抗剂。
  • HY-13665
    Leuprolide Acetate Agonist 99.56%
    Leuprolide acetate (Leuprorelin acetate) 是一种有效的促性腺激素释放激素 (GNRH)受体激动剂,用于治疗前列腺癌,子宫内膜异位症,子宫肌瘤。
  • HY-13581A
    Buserelin Acetate Agonist 99.75%
    Buserelin Acetate是一个GnRH的激动剂。
  • HY-P0009A
    Cetrorelix Acetate Antagonist 99.69%
    Cetrorelix Acetate是 GnRH 受体的强效拮抗剂,其 IC50 值为 1.21 nM。
  • HY-16474
    Relugolix Antagonist >98.0%
    Relugolix是一个新颖的,非肽的能够口服的GnRH拮抗剂,IC50值是0.33 nM。
  • HY-P1022
    Kisspeptin-54(human) (Metastin(human)) 是一种 Kisspeptin 受体 (KISS1GPR54) 的内源性配体,以高亲和力结合大鼠和人类 GPR54 受体,其 Ki 值分别为 1.81 nM 和 1.45 nM。Kisspeptin-54(human) 可抑制肿瘤转移并刺激促性腺激素分泌。
  • HY-P1022A
    Kisspeptin-54(human) TFA
    Kisspeptin-54(human) TFA (Metastin(human) TFA) 是一种 Kisspeptin 受体 (KISS1GPR54) 的内源性配体,以高亲和力结合大鼠和人类 GPR54 受体,其 Ki 值分别为 1.81 nM 和 1.45 nM。Kisspeptin-54(human) TFA 可抑制肿瘤转移并刺激促性腺激素分泌。
  • HY-14369
    Elagolix sodium Antagonist 99.66%
    Elagolix sodium 是一种人的 GnRH 受体 (GnRHR) 拮抗剂,其 IC50Ki 值分别为 0.25 和 3.7 nM。
  • HY-14789
    (R)-Elagolix Antagonist 98.06%
    Elagolix是一种高度有效的, 选择性, 口服活性的, 短期的, 非肽类促性腺激素释放激素受体 (GnRH受体) 拮抗剂 (KD = 54 pM)。
  • HY-13673A
    Goserelin acetate Agonist 99.96%
    Goserelin acetate (ICI 118630 acetate) 是GnRH激动剂。
  • HY-17405
    Alarelin Acetate Agonist 99.43%
    Alarelin acetate是合成的GnRH激动剂。
  • HY-13534
    Abarelix Antagonist
    Abarelix (R3827; PPI 149) 是有效的促性腺激素释放激素 (GnRH) 拮抗剂,用于治疗前列腺癌。
  • HY-13534A
    Abarelix Acetate Antagonist 99.62%
    Abarelix Acetate (PPI 149 Acetate; R 3827 Acetate) 是一种有效的促性腺激素释放激素 (GnRH) 拮抗剂,用于前列腺癌的研究。
  • HY-P0051
    Lecirelin Agonist 99.80%
    Lecirelin 是 GnRH 的合成类似物,可用于治疗牛卵巢滤泡囊肿。
  • HY-13673
    Goserelin Agonist
    Goserelin(ICI 118630)是注射型促性腺激素释放激素(GnRH)超激动剂。
  • HY-133080
    BAY-784 Antagonist
    BAY-784 是一种促性腺激素释放激素受体 (GnRH-R) 拮抗剂探针,对人和大鼠 GnRH-RIC50 分别为 21 和 24 nM。
  • HY-U00289
    opigolix Antagonist
    Opigolix 是一种促性腺激素释放激素 (GnRH) 受体拮抗剂,可用于子宫内膜异位症和风湿性关节炎等疾病的研究。
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