2. GPCR/G Protein
  3. GnRH Receptor
  4. Fsh receptor-binding inhibitor fragment(bi-10)

Fsh receptor-binding inhibitor fragment(bi-10) 

目录号: HY-P4190
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摩尔计算器

FSH receptor-binding inhibitor fragment(bi-10) 是一种有效的 FSH 拮抗剂。FSH receptor-binding inhibitor fragment(bi-10) 阻断 FSH 与 FSHR 的结合，并在受体水平上改变 FSH 的作用。FSH receptor-binding inhibitor fragment(bi-10) 导致小鼠排卵抑制和卵泡闭锁。FSH receptor-binding inhibitor fragment(bi-10) 通过下调卵巢中 FSHR 和 ERβ 的过度表达来抑制卵巢癌发生。

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Fsh receptor-binding inhibitor fragment(bi-10) Chemical Structure

Fsh receptor-binding inhibitor fragment(bi-10) Chemical Structure

CAS No. : 163973-98-6

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Fsh receptor-binding inhibitor fragment(bi-10) 相关抗体

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生物活性

FSH receptor-binding inhibitor fragment(bi-10) is a potent FSH antagonist. FSH receptor-binding inhibitor fragment(bi-10) blocks the binding of FSH to FSHR, and alteres FSH action at the receptor level. FSH receptor-binding inhibitor fragment(bi-10) results in the suppression of ovulation and causes follicular atresia of mice. FSH receptor-binding inhibitor fragment(bi-10) has the potential for utilizing to restrain the carcinogenesis of ovarian cancer by down-regulating overexpression of FSHR and ERβ in the ovaries[1].

体内研究
(In Vivo)

FSH receptor-binding inhibitor fragment(bi-10) (10, 20, 30, 40 mg/kg; 肌肉注射; 每天1次; 连续5天) 在大剂量 (30 mg/kg-40 mg/kg) 可抑制卵巢和卵泡发育，降低卵巢中 ERβ 和 FSHR mRNA 和蛋白质的表达水平，抑制 E2 的产生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Prepuberty Kunming female mice of 21-days old and body weight of 22.3±1.52g[1]
Dosage: 10, 20, 30, 40 mg/kg
Administration: Intramuscularly injection; once a day for five consecutive days
Result: Could attenuate FSH promoting effect on the follicular development, resulting in the poor maturation of ovarian follicles.
High dose (40mg/kg) treatment blocked the follicle development of mice.
High dose of FRBI (40mg/kg) treatment blocked the follicle development of mice.
分子量

1058.06

Formula

C42H67N13O19
CAS 号
Sequence

Thr-Glu-Asn-Leu-Glu-Pro-Asn-Gly-Glu-Gly-NH2
Sequence Shortening

TENLEPNGEG-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Fsh receptor-binding inhibitor fragment(bi-10) 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Fsh receptor-binding inhibitor fragment(bi-10)163973-98-6GnRH ReceptorGonadotropin releasing hormone receptorGNRHRFSHFSHRovulationfollicular atresiacarcinogenesisovarian cancerERβInhibitorinhibitorinhibit

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