1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. GSNOR

GSNOR (S-亚硝基谷胱甘肽还原酶)

S-nitrosoglutathione reductase

S-Nitrosoglutathione reductase (GSNOR) is a member of the alcohol dehydrogenase family (ADH) that regulates the levels of S-nitrosothiols (SNOs) through catabolism of S-nitrosoglutathione (GSNO).

GSNOR reduces the nitric oxide (NO) adduct S-nitrosoglutathione (GSNO), an essential reservoir for NO bioactivity. In plants, GSNOR has been found to be important in resistance to bacterial and fungal pathogens. GSNOR is ubiquitously expressed and catalyzes denitrosylation of GSNO, thereby downregulating protein S-nitrosylation in β-cells.

GSNOR activity appears to be necessary for normal development and fertility under optimal growth conditions.

GSNOR 相关产品 (3):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-14984
    N6022 Inhibitor 99.91%
    N6022 是一种有效的,选择性的,可逆的 S-Nitrosoglutathione reductase (GSNOR) 抑制剂,IC50 值为 8 nM。
    N6022
  • HY-109027
    Cavosonstat Inhibitor 99.22%
    Cavosonstat (N91115) 是一种具有口服活性的 S-nitrosoglutathione reductase (GSNOR) 抑制剂。Cavosonstat 是一种 CFTR 稳定剂,可用于囊性纤维化研究。
    Cavosonstat
  • HY-110295
    SPL-334 Inhibitor
    SPL-334 是一种有效的选择性 S-亚硝基谷胱甘肽还原酶 (GSNOR) 抑制剂。SPL-334 导致气道中 Th2 细胞因子 IL-5IL-13 的产生以及趋化因子 CCL11 (eotaxin-1) 的水平显着降低。SPL-334 可用于过敏性气道炎症的研究。
    SPL-334