1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Lactate Dehydrogenase

Lactate Dehydrogenase (乳酸脱氢酶)

Lactate Dehydrogenase (LDH) is an enzyme that catalyzes the conversion of pyruvate, the end product of glycolysis, into lactate (and vice versa) with concomitant interconversion of NADH and NAD+. LDH is comprised of two major subunits, LDH-A and LDH-B, which can assemble into five different isoenzymes (LDH1, LDH2, LDH3, LDH4, and LDH5).

LDH-A is also known as the M subunit as it is predominantly found in skeletal muscle, and LDH-B is also known as the H subunit as it is predominantly found in the heart. LDH-A is a vital metabolic enzyme that is associated with cancer development, invasion, and metastasis. LDH-A is also the key player of the Warburg effect. LDH-A has been reported to correlate with clinicopathologic characteristics and survival outcome of multiple cancers. The inhibition of LDH-A has an anti-proliferative effect on primary breast tumors. LDH-B is a crucial glycolytic enzyme that catalyses conversion of lactate and NAD+ to pyruvate, NADH and H+. LDHB plays an important role in autophagy in cancer cells.

Lactate Dehydrogenase 相关产品 (14):

目录号 产品名 作用方式 纯度
  • HY-100681
    GSK2837808A Inhibitor ≥99.0%
    GSK2837808A 是有效和选择性的乳酸脱氢酶A (LDHA) 抑制剂,对LDHA 和 LDHB的 IC50 值分别为1.9 和14 nM。
  • HY-16214
    FX-11 Inhibitor 98.11%
    FX-11 (LDHA Inhibitor FX11) 是有效的乳酸脱氢酶 A (LDHA) 抑制剂。FX-11 对 HeLa 宫颈癌细胞的 IC 50 值为 23.3 μM,Ki 值为 8 μM。
  • HY-100742A
    (R)-GNE-140 Inhibitor 99.20%
    (R)-GNE-140 是一种有效的 LDHA 抑制剂,对 LDHA 和 LDHB 的 IC50 值分别为 3 nM 和 5 nM;(R)-GNE-140 的活性是 S 型异构体的 18 倍。
  • HY-100742
    GNE-140 racemate Inhibitor ≥98.0%
    GNE-140 racemate 是一种 (R)-GNE-140 和 (S)-GNE-140 的外消旋混合物。GNE-140 racemate 也是一种有效的乳酸脱氢酶 A (LDHA) 抑制剂。
  • HY-111108
    LDH-IN-1 Inhibitor 99.84%
    LDH-IN-1是一种新的基于吡唑的人乳酸脱氢酶 (LDH) 抑制剂,对于 LDHA 和 LDHB的 IC50 值分别为32和27nM。
  • HY-139319
    LDHA-IN-3 Inhibitor
    LDHA-IN-3 作为一种硒苯化合物,是一种有效的非竞争性乳酸脱氢酶(LDHA) 抑制剂(IC50=145.2 nM)。LDHA-IN-3 可用于癌症研究。
  • HY-N2177
    3-Dehydrotrametenolic acid Inhibitor ≥99.0%
    3-​Dehydrotrametenolic acid,分离于茯苓菌核,是一种乳酸脱氢酶 (LDH) 抑制剂。3-​Dehydrotrametenolic acid 促进体外脂肪细胞分化,在体内起胰岛素增敏剂的作用。3-​Dehydrotrametenolic acid 诱导细胞凋亡,具有抗癌活性。
  • HY-N7393
    Isomalt ≥98.0%
    Isomalt (Palatinitol) 是一种耐受性良好,无毒的多元醇和蛋白质稳定的赋形剂,在冷冻干燥过程中可适度稳定乳酸脱氢酶 (LDH),并在储存期间表现更好。 Isomalt 传统上在食品工业中用作甜味剂,并在制药中用作压片赋形剂。
  • HY-W040073
    Nifurtimox Inhibitor 99.65%
    Nifurtimox 是一种用于锥虫病 (Trypanosoma cruzi) 的抗虫剂。Nifurtimox 有潜力用于神经母细胞瘤细胞的研究。Nifurtimox 影响乳酸脱氢酶 (LDH) 活性。
  • HY-100742B
    (S)-GNE-140 Inhibitor 99.04%
    (S)-GNE-140 是活性较小的 GNE-140 的对映体,能够抑制乳酸脱氢酶 A (LDHA)。
  • HY-N2498
    Glomeratose A Inhibitor 99.79%
    Glomeratose A 是一种乳酸脱氢酶 lactate dehydrogenase 抑制剂,是从远志 Polygala tenuifolia 分离的。
  • HY-135658
    hDHODH-IN-1 Inhibitor 99.61%
    hDHODH-IN-1 是一种人二氢乳清酸脱氢酶 (hDHODH) 抑制剂, 具有抗炎作用。
  • HY-135648
    PfDHODH-IN-1 Inhibitor
    PfDHODH-IN-1 是一种 Leflunomide 活性代谢物的类似物。PfDHODH-IN-1 是一种恶性疟原虫二氢乳清酸脱氢酶 (PfDHODH) 抑制剂。PfDHODH-IN-1 具有抗疟疾活性。
  • HY-135654
    hDHODH-IN-2 Inhibitor
    hDHODH-IN-2 是一种 Leflunomide 活性代谢物的类似物。hDHODH-IN-2 是一种人二氢乳清酸脱氢酶 hDHODH 抑制剂,具有抗炎活性。
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