1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. Monoamine Transporter

Monoamine Transporter

Monoamine transporters (MATs) are protein structures that function as integral plasma-membrane transporters to regulate concentrations of extracellular monoamine neurotransmitters. Three major classes of MATs (SERT, DAT, NET) are responsible for the reuptake of their associated amine neurotransmitters (serotonin, dopamine, norepinephrine). MATs are located just outside the synaptic cleft (peri-synaptically), transporting monoamine transmitter overflow from the synaptic cleft back to the cytoplasm of the pre-synaptic neuron. MAT regulation generally occurs throughphosphorylation and posttranslational modification. Due to their significance in neuronal signaling, MATs are commonly associated with drugs used to treat mental disorders as well as recreational drugs. Compounds targeting MATs range from medications such as the wide variety of tricyclic antidepressants, selective serotonin reuptake inhibitors to stimulantmedications and amphetamine.

Monoamine Transporter 相关产品 (13):

Cat. No. Product Name Effect Purity
  • HY-N0480
    Reserpine Inhibitor 99.83%
    Reserpine 是囊泡单胺转运蛋白 2 (VMAT2) 的抑制剂。
  • HY-16771
    Valbenazine Inhibitor 99.03%
    Valbenazine 是 四苯喹嗪 α 异构体的前体物质,能够抑制 VMAT2 的功能。
  • HY-15793
    NBI-98782 Inhibitor 99.80%
  • HY-B0590B
    (+)-Tetrabenazine Inhibitor 99.81%
    (+)-Tetrabenazine ((+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine) 是一个可逆转的VMAT-2的抑制剂。
  • HY-N0480A
    Reserpine hydrochloride Inhibitor 99.84%
    Reserpine (hydrochloride) 是囊泡单胺转运蛋白 2 (VMAT2) 的抑制剂。
  • HY-B0590A
    Tetrabenazine Racemate Inhibitor >98.0%
    Tetrabenazine (Racemate)是一个有选择性和可逆转的VMAT-2抑制剂。
  • HY-17590
    Radafaxine hydrochloride Inhibitor 99.47%
    Radafaxine hydrochloride (GW-353162A) 是 bupropion 的代谢活化物,DAT/NET 转运体抑制剂,能选择性的抑制去甲肾上腺素的再吸收。
  • HY-B0590
    Tetrabenazine Inhibitor >99.0%
  • HY-101416
    Vanilpyruvic acid >98.0%
    Vanilpyruvic acid是儿茶酚胺代谢物和香草酸的前体。
  • HY-G0025
    Tetrabenazine Metabolite Inhibitor
    Tetrabenazine Metabolite 是 Tetrabenazine 的一种活性代谢物。Tetrabenazine Metabolite 是一种囊泡单胺转运蛋白 2 (VMAT2) 抑制剂。对 VMAT2 具有高亲和力,Ki=13.4 nM。Tetrabenazine Metabolite 可用于治疗与亨廷顿氏病和其他多动障碍相关的舞蹈病。
  • HY-15793A
    Trans (2,3)-Dihydrotetrabenazine Inhibitor
    Trans (2,3)-Dihydrotetrabenazine ((2R,3R,11bR)-rel-Dihydrotetrabenazine), 是抗精神病药物Tetrabenazine的体内代谢物,能够抑制囊泡单胺转运体 2 (VMAT2)
  • HY-B0590S
    Tetrabenazine D6 Inhibitor >99.0%
    Tetrabenazine D6是Tetrabenazine的氘代化合物标准品。
  • HY-B0590S1
    (+)-Tetrabenazine D6
    (+)-Tetrabenazine D6 是 (+)-Tetrabenazine 的氘代化合物标准品。(+)-Tetrabenazine 是一种不可逆的 vesicular monoamine transporter 2 抑制剂。
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