1. Membrane Transporter/Ion Channel
  2. Monoamine Transporter
  3. FFN511

FFN511 是一种靶向神经元囊泡单胺转运体 2 (VMA T2) 的荧光假神经递质 (FFNs)。FFN511 可抑制 5-羟色胺与含 VMA T2 的膜结合,其 IC50 值为 1 µM。FFN511 能直接反映细胞外渗过程中的释放动态,可用于标记活体皮质-纹状体急性切片中的多巴胺能神经末梢。

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FFN511 Chemical Structure

FFN511 Chemical Structure

CAS No. : 1004548-96-2

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Other Forms of FFN511:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FFN511 is a potent fluorescent false neurotransmitters (FFNs) that targets neuronal vesicular monoamine transporter 2 (VMA T2). FFN511 inhibits serotonin binding to VMA T2-containing membranes with an IC50 of 1 µM. FFN511 directly images the dynamics of release during exocytosis, can be used to label dopamine terminals in live cortical-striatalacute slices[1][2].

体外研究
(In Vitro)

FFN511 (350 nM; 30 min) accumulats in a pattern consistent with LDCVs in cultured mouse chromaffin cells, and the accumulation is abolished by the lipophilic base chloroquine[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: mouse chromaffin cells
Concentration: 350 nM
Incubation Time: 30 min
Result: Accumulated in cultured mouse chromaffin cells (the same as LDCVs), and the accumulation could be abolished by the lipophilic base chloroquine, which collapses the vesicle pH gradient.
分子量

284.35

Formula

C17H20N2O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
FFN511
目录号:
HY-103465
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