1. Signaling Pathways
  2. GPCR/G Protein
  3. Motilin Receptor

Motilin Receptor (胃动素受体)

Motilin receptor is a G protein-coupled receptor that binds motilin. Motilin in turn is an intestinal peptide that stimulates contraction of gutsmooth muscle. The main function of motilin is to increase the migrating myoelectric complex component of gastrointestinal motility and stimulate the production of pepsin. Motilin is called "housekeeper of the gut" because it improves peristalsis in the small intestine and clears out the gut to prepare for the next meal. A high level of motilin secreted between meals into the blood stimulates the contraction of the fundus and antrum and accelerates gastric emptying. It then contracts the gallbladder and increases the squeeze pressure of the lower esophageal sphincter. Other functions of motilin include increasing the release of pancreatic polypeptide and somatostatin.

Motilin Receptor 相关产品 (6):

目录号 产品名 作用方式 纯度
  • HY-10922
    Camicinal Agonist
    Camicinal (GSK962040) 是胃动素受体激动剂,pEC50为7.9。
  • HY-P1037
    Motilin (26-47), human, porcine Agonist 98.98%
    Motilin (26-47), human, porcine 是一种内源性的 motilin 受体激动剂,在中国仓鼠卵巢细胞中,Ki 值和 EC50 值分别为 2.3 nM 和 0.3 nM。
  • HY-107642
    MA-2029 Antagonist ≥99.0%
    MA-2029 是一种选择性、口服活性和竞争性的胃动素受体 (motilin receptor) 拮抗剂 (IC50=4.9 nM)。MA-2029 对胃动素受体的选择性高于其他受体和离子通道。MA-2029 可用于与胃肠动力紊乱相关的胃肠道疾病。
  • HY-P1233
    ANQ-11125 Antagonist
    ANQ-11125 是一种有效的、选择性胃动素拮抗剂,pKd 值为 8.24。ANQ-11125 在体外阻断 motilide 引起的收缩。
  • HY-P1233A
    ANQ-11125 TFA Antagonist
    ANQ-11125 TFA 是一种有效的、选择性胃动素拮抗剂,pKd 值为 8.24。ANQ-11125 TFA 在体外阻断 motilide 引起的收缩。
  • HY-10922A
    Camicinal hydrochloride Agonist
    Camicinal hydrochloride (GSK962040 hydrochloride) 是胃动素受体激动剂,pEC50 为 7.9。
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