1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. NEDD8-activating Enzyme

NEDD8-activating Enzyme (NEDD8活化酶)

NAE

NEDD8-activating enzyme (NAE) is upstream of the 20S proteasome in the ubiquitin/proteasome pathway and catalyzes the first step in the neddylation pathway. NAE is an essential component of the NEDD8 conjugation pathway that controls the activity of the cullin-RING subtype of ubiquitin ligases, thereby regulating the turnover of a subset of proteins upstream of the proteasome. Substrates of cullin-RING ligases have important roles in cellular processes associated with cancer cell growth and survival pathways.

The ubiquitin-like protein NEDD8 is a critical signaling molecule implicated in the functional maintenance and homeostasis of cells. Dysregulation of this process is involved in a variety of human diseases, including cancer. Therefore, NEDD8-activating enzyme E1 (NAE), the only activation enzyme of the neddylation pathway, has been an emergent anticancer target.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-70062
    Pevonedistat Inhibitor 99.98%
    Pevonedistat (MLN4924) 是一种有效,选择性的NEDD8 活化酶 (NAE) 抑制剂,IC50 为 4.7 nM。
    Pevonedistat
  • HY-10484
    Pevonedistat hydrochloride Inhibitor 99.26%
    Pevonedistat hydrochloride (MLN4924 hydrochloride) 是一种有效,选择性的 NEDD8 活化酶 (NEDD8-activating enzyme) 抑制剂,IC50 为 4.7 nM。
    Pevonedistat hydrochloride
  • HY-128586
    TAS4464 Inhibitor 99.52%
    TAS4464 是一种高效选择性的 NEDD8 活化酶 (NAE) 抑制剂,IC50 值为 0.955 nM。
    TAS4464
  • HY-128586A
    TAS4464 hydrochloride Inhibitor 98.12%
    TAS4464 (hydrochloride) 是一种高效选择性的 NEDD8 活化酶 (NAE) 抑制剂,IC50 值为 0.955 nM。
    TAS4464 hydrochloride
  • HY-111505
    NAcM-OPT Inhibitor 99.65%
    NAcM-OPT 是一种口服生物可利用的 cullin neddylation 1 (DCN1) 抑制剂,有效抑制 DCN1-UBE2M 相互作用。
    NAcM-OPT
  • HY-101790A
    ZM223 hydrochloride Inhibitor 99.21%
    ZM223 hydrochloride 是一种有效的非共价 NEDD8 活化酶 (NAE) 抑制剂,具有口服活性。
    ZM223 hydrochloride
  • HY-101790
    ZM223 Inhibitor
    ZM223 是一种有效的非共价 NEDD8 活化酶 (NAE) 抑制剂,具有口服活性。
    ZM223
  • HY-161268
    NAE-IN-1 Inhibitor
    NAE-IN-1 (compound X-10) 是一种有效的 NAE1 抑制剂。NAE-IN-1 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G2/M 期。NAE-IN-1 增加 ROS 水平并阻止细胞迁移。NAE-IN-1 显示出抗增殖活性。
    NAE-IN-1
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