1. Metabolic Enzyme/Protease
  2. NEDD8-activating Enzyme
  3. ZM223 hydrochloride

ZM223 hydrochloride 

目录号: HY-101790A
产品使用指南

ZM223 hydrochloride 是一种有效的非共价 NEDD8 活化酶 (NAE) 抑制剂,具有口服活性。

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ZM223 hydrochloride Chemical Structure

ZM223 hydrochloride Chemical Structure

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Size Price Stock Quantity
5 mg ¥4500 In-stock
10 mg ¥7500 In-stock
50 mg ¥22500 Get quote
100 mg ¥33500 Get quote
200 mg   Get quote  
500 mg   Get quote  

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Description

ZM223 hydrochloride is an orally active, potent non-covalent NEDD8 activating enzyme (NAE) inhibitor with excellent anticancer activity[1].

IC50 & Target

NEDD8 activating enzyme (NAE)[1]

In Vitro

ZM223 hydrochloride (0.1-1 μM; 4 hours) causes a decrease in the level of NEDD8 and an increase in the downstream UBC12 protein[1].
ZM223 hydrochloride (0.1-1 μM; 4 hours) inhibits both HCT-116 and U-2OS cancer cells with IC50s of 100 and 122 nM, respectively[1].

Cell Viability Assay[1]

Cell Line: HCT116 colon cancer cells and U-2OS osteosarcoma cells
Concentration: 0.1 μM, 1 μM
Incubation Time: 4 hours
Result: Inhibited both HCT-116 and U-2OS cancer cells.
Molecular Weight

538.99

Formula

C₂₃H₁₈ClF₃N₄O₂S₂

SMILES

O=C(C1=CC=C(C(F)(F)F)C=C1)NC2=NC3=CC=C(NC(CSC4=CC=C(N)C=C4)=O)C=C3S2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
ZM223 hydrochloride
目录号:
HY-101790A
需求量:

ZM223 hydrochloride

Cat. No.: HY-101790A