1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. Neurotensin Receptor
  4. NTR2 Isoform


NTR2 (neurotensin receptor 2) belongs to the G protein-coupled receptor family that activates a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in the brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.

NTR2 相关产品 (1):

目录号 产品名 作用方式 纯度
  • HY-14277A
    Levocabastine hydrochloride Antagonist ≥99.0%
    Levocabastine (R 50547) hydrochloride 是一种强效选择性组胺 H1 受体拮抗剂。Levocabastine hydrochloride 也是一种选择性、高亲和力的神经降压素受体亚型 2 (NTR2) 拮抗剂,对 mNTR2 的 Ki 值为 17 nM。Levocabastine hydrochloride 可作为 VLA-4 拮抗剂,干扰过敏性结膜炎 (AC) 结膜嗜酸性粒细胞的浸润。