1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog 相关产品 (61):

Cat. No. Product Name Effect Purity
  • HY-90006
    5-Fluorouracil Inhibitor 99.86%
    5-Fluorouracil 是一种有效的抗肿瘤剂,通过抑制胸苷酸合成酶从而消耗细胞内dTTP来影响嘧啶合成。
  • HY-17026
    Gemcitabine Inhibitor 99.92%
    Gemcitabine (NSC 613327;LY188011) 是一种 DNA合成 抑制剂,抑制 BxPC-3,Mia Paca-2,PANC-1,PL-45 和 AsPC-1细胞生长的 IC50 分别为 37.6, 42.9, 92.7, 89.3 和 131.4 nM。
  • HY-10586
    5-Azacytidine Inhibitor 99.97%
    5-Azacytidine是胞苷的核苷类似物,其通过捕获 DNA甲基转移酶 特异性地抑制DNA甲基化。
  • HY-13605
    Cytarabine 99.99%
    Cytarabine 是一种核苷类似物,可引起 S 期细胞周期停滞并抑制 DNA聚合酶。Cytarabine 抑制DNA 合成IC50为16 nM。
  • HY-15910
    5-BrdU Inhibitor 99.99%
    5-BrdU是一种核苷类似物,可与胸苷竞争掺入DNA。5-BrdU通常用于检测增殖细胞。
  • HY-111647
    N2-Methylguanosine 98.07%
    N2-Methylguanosine 是一种修饰的核苷,修饰发生在 tRNA 的几个特定位点。
  • HY-128671
    6-​Thioinosine
    6-​Thioinosine (6TI) 是一种嘌呤抗代谢物,为抗脂肪形成剂,能够降低 PPAR γC/EBPα 及其目标基因 LPL,CD36,aP2 和 LXRα 的 mRNA 水平。
  • HY-122524
    7-Methylguanosine Inhibitor
    7-Methylguanosine 是一种新型的 cNIIIB nucleotidase 抑制剂,IC50 值为 87.8 ± 7.5 µM。
  • HY-B0003
    Gemcitabine Hydrochloride Inhibitor 99.93%
    Gemcitabine (Hydrochloride) 是一种DNA合成抑制剂,在131.4 nM -2,PANC-1,PL-45和AsPC-1细胞中的 IC50 分别为37.6,42.9,92.7,89.3 和 131.4 nM。
  • HY-B0016
    Capecitabine Inhibitor 99.97%
    Capecitabine 是一种可用于口服的前药,可由胸苷磷酸化酶催化转变为其活性代谢物 Fluorouracil (FU)。
  • HY-16209
    Forodesine hydrochloride Inhibitor 99.86%
    Forodesine hydrochloride是有效,可口服的嘌呤核苷磷酸化酶 PNP 抑制剂,其中IC50 范围为0.48至1.57 nM。
  • HY-B0228
    Adenosine Chemical 99.84%
    Adenosine 通过β-N9-糖苷键与核糖分子(呋喃核糖)部分连接的腺嘌呤分子组成的核苷。
  • HY-B0069
    Fludarabine Inhibitor 99.28%
    Fludarabine (F-ara-A; NSC 118218) 是 DNA 合成抑制剂,也抑制 STAT1 磷酸化。
  • HY-B0078
    Dacarbazine Inhibitor >98.0%
    Dacarbazine(DTIC-Dome; DTIC)有抗黑色素瘤活性。
  • HY-16478
    Trifluridine/tipiracil hydrochloride mixture Inhibitor 99.72%
    Trifluridine-tipiracil hydrochloride mixture (TAS-102) 是一种新型的口服组合药物。由基于胸苷的抗肿瘤核苷类似物,三氟胸苷和有效的胸苷磷酸化酶 (thymidine phosphorylase) 抑制剂派替西西以1比0.5比例组成。
  • HY-B0097
    Floxuridine Inhibitor 99.93%
    Floxuridine (5-fluorodeoxyuridine)为抗代谢剂,可抑制PEPT1,GI50为5.1 μM。
  • HY-10821
    Raltitrexed Inhibitor 99.21%
    Raltitrexed是一种用于化疗的抗代谢药物,通过抑制胸苷酸合成酶起作用。
  • HY-B0028
    Fludarabine phosphate Inhibitor 99.69%
    Fludarabine phosphate (NSC 118218 phosphate) 是一种腺苷和脱氧腺苷类似物,与 dATP 竞争,并入到 DNA,导致 DNA 合成受阻。
  • HY-A0061
    Trifluridine 99.69%
    Trifluridine (Trifluorothymidine; 5-Trifluorothymidine; TFT) 是不可逆的胸苷酸合酶抑制剂,从而抑制 DNA合成。Trifluridine 是用于单纯疱疹病毒 (HSV) 感染的抗病毒药物。
  • HY-B0277
    Vidarabine Inhibitor >98.0%
    Vidarabine (Ara-A) 是核苷类抗生素,分离自链霉菌,能抗单纯性疱疹和水痘-带状疱疹病毒。
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