Adenosine (Synonyms: 腺苷; Adenine riboside; D-Adenosine)

目录号: HY-B0228 纯度: 99.96%: Data Sheet SDS COA 产品使用指南
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Adenosine (Adenine riboside) 是一种普遍存在的内源性分泌物，是通过四种G蛋白偶联受体（A1、A2A、A2B 和 A3）的起作用。Adenosine 几乎影响细胞生理学的所有方面，包括神经元活动、血管功能、血小板聚集和血细胞调节。

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Adenosine Chemical Structure

CAS No. : 58-61-7

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥126	In-stock
100 mg	￥115	In-stock
500 mg	￥350	In-stock
1 g	￥465	In-stock
5 g	￥650	In-stock
10 g	￥850	In-stock
25 g	￥1150	In-stock
50 g	￥1495	In-stock
100 g	￥1944	In-stock
> 100 g		询价

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Other Forms of Adenosine:

Adenosine-d In-stock
Adenosine-¹³C₅ In-stock
(R)-3-Hydroxybutanoic acid-¹³C₂ sodium In-stock
Adenosine-¹⁵N₅ In-stock
Adenosine-d₁₃ In-stock
Adenosine-¹³C₁₀ In-stock
Adenosine-1′-¹³C In-stock
Adenosine-¹³C In-stock
Adenosine-d₂ In-stock
Adenosine-d-1 In-stock
Adenosine 5'-diphosphate disodium In-stock
Adenosine (Standard) In-stock
Adenosine-d₉ 询价
Adenosine-2′-¹³C 询价
Adenosine-3′-¹³C 询价
Adenosine-d-2 询价
Adenosine-¹³C₁₀,¹⁵N₅ 询价
Adenosine-¹⁵N 询价

MCE 顾客使用本产品发表的 16 篇科研文献

: Adenosine purchased from MCE. Usage Cited in: Int J Mol Med. 2016 Sep;38(3):969-75. [Abstract]; Effects of Adenosine and CGS21680 on CD39 and CD73 expression. (A) Adenosine and CGS21680 promote the expression of CD39. (B) Adenosine and CGS21680 promote the expression of CD73. GAPDH is used as an internal reference.

Adenosine 相关产品

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生物活性
纯度 & 产品资料
参考文献

生物活性

Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation^[1]^[2].

IC₅₀ & Target

Human Endogenous Metabolite

Microbial Metabolite

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A-431	IC₅₀	195 μM Compound: Adenosine	Inhibition of erbB-1 receptor tyrosine kinase from A431 human epidermoid carcinoma cells Inhibition of erbB-1 receptor tyrosine kinase from A431 human epidermoid carcinoma cells	[PMID: 9089334]
CHO	EC₅₀	0.29 μM Compound: adenosine	Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as increase of intracellular calcium level Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as increase of intracellular calcium level	[PMID: 20541935]
CHO	EC₅₀	0.29 μM Compound: adenosine	Agonist activity at human adenosine A3 receptor expressed in CHO cells Agonist activity at human adenosine A3 receptor expressed in CHO cells	[PMID: 21388809]
CHO	EC₅₀	0.31 μM Compound: adenosine	Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as increase of intracellular calcium level Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as increase of intracellular calcium level	[PMID: 20541935]
CHO	EC₅₀	0.31 μM Compound: adenosine	Agonist activity at human adenosine A1 receptor expressed in CHO cells Agonist activity at human adenosine A1 receptor expressed in CHO cells	[PMID: 21388809]
CHO	EC₅₀	0.7 μM Compound: adenosine	Agonist activity at human adenosine A2A receptor expressed in CHO cells assessed as increase of intracellular calcium level Agonist activity at human adenosine A2A receptor expressed in CHO cells assessed as increase of intracellular calcium level	[PMID: 20541935]
CHO	EC₅₀	0.7 μM Compound: adenosine	Agonist activity at human adenosine A2A receptor expressed in CHO cells Agonist activity at human adenosine A2A receptor expressed in CHO cells	[PMID: 21388809]
CHO	EC₅₀	23500 nM Compound: AR-1	Agonist activity at human adenosine A2B receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosine Agonist activity at human adenosine A2B receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosine	[PMID: 26356532]
CHO	EC₅₀	24 μM Compound: adenosine	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase of intracellular calcium level Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase of intracellular calcium level	[PMID: 20541935]
CHO	EC₅₀	24 μM Compound: adenosine	Agonist activity at human adenosine A2B receptor expressed in CHO cells Agonist activity at human adenosine A2B receptor expressed in CHO cells	[PMID: 21388809]
CHO	EC₅₀	290 nM Compound: AR-1	Agonist activity at human adenosine A3 receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosine Agonist activity at human adenosine A3 receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosine	[PMID: 26356532]
CHO	EC₅₀	310 nM Compound: AR-1	Agonist activity at human adenosine A1 receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosine Agonist activity at human adenosine A1 receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosine	[PMID: 26356532]
CHO	EC₅₀	730 nM Compound: AR-1	Agonist activity at human adenosine A2A receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosine Agonist activity at human adenosine A2A receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosine	[PMID: 26356532]
COS-7	EC₅₀	1.04 μM Compound: adenosine	Activity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assay Activity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assay	[PMID: 16640329]
Detroit 98	ED₅₀	0.08 μM Compound: 2	Concentration that inhibited the growth of cultured human detroit 98 cells. Concentration that inhibited the growth of cultured human detroit 98 cells.	[PMID: 7131482]
HEK-293T	EC₅₀	0.039 μM Compound: Adenosine	Agonist activity at human A1AR expressed in HEK293T/17 cells assessed as inhibition of isoproterenol-induced cAMP accumulation incubated for 10 mins by luciferase reporter assay Agonist activity at human A1AR expressed in HEK293T/17 cells assessed as inhibition of isoproterenol-induced cAMP accumulation incubated for 10 mins by luciferase reporter assay	[PMID: 22738238]
HEp-2	IC₅₀	0.7 μM Compound: 1	Compound was evaluated for cytotoxicity against H.Ep.-2 cells, and concentration required to inhibit the growth of treated cells to 50% of untreated control. Compound was evaluated for cytotoxicity against H.Ep.-2 cells, and concentration required to inhibit the growth of treated cells to 50% of untreated control.	[PMID: 6708054]
HEp-2	IC₅₀	20 μM Compound: 1	Compound was evaluated for cytotoxicity against H.Ep.-2 (AK-) cells and concentration required to inhibit the growth of treated cells to 50% of untreated control Compound was evaluated for cytotoxicity against H.Ep.-2 (AK-) cells and concentration required to inhibit the growth of treated cells to 50% of untreated control	[PMID: 6708054]
HeLa	IC₅₀	10.8 μM Compound: 37	Inhibition of cytopathogenicity of herpes simplex type 1 virus (HSV-1)(KOS) in Hela cell culture. Inhibition of cytopathogenicity of herpes simplex type 1 virus (HSV-1)(KOS) in Hela cell culture.	[PMID: 7473592]
HeLa	IC₅₀	98.85 μM Compound: 37	Concentration required to cause microscopically visible change or disruption in about 50% of Hela cell sheet. Concentration required to cause microscopically visible change or disruption in about 50% of Hela cell sheet.	[PMID: 7473592]
HepG2	IC₅₀	18.46 μM Compound: 35	Inhibition of PCSK9 mRNA expression in human HepG2 cells by SYBR Green I dye-based qRT-PCR analysis Inhibition of PCSK9 mRNA expression in human HepG2 cells by SYBR Green I dye-based qRT-PCR analysis	[PMID: 30448414]
L1210	EC₅₀	1.869 mM Compound: 2	Antitumor activity against mouse L1210 cells assessed as inhibition of [3H]thymidine incorporation after 72 hrs Antitumor activity against mouse L1210 cells assessed as inhibition of [3H]thymidine incorporation after 72 hrs	[PMID: 24915876]
L1210	IC₅₀	0.991 mM Compound: 2	Cytotoxicity against mouse L1210 cells assessed as inhibition of cell viability after 72 hrs by MTT assay Cytotoxicity against mouse L1210 cells assessed as inhibition of cell viability after 72 hrs by MTT assay	[PMID: 24915876]
L929	ED₅₀	0.3 μM Compound: 2	Concentration that inhibited the growth of Mouse L cells. Concentration that inhibited the growth of Mouse L cells.	[PMID: 7131482]
PBMC	IC₅₀	1.867 mM Compound: 2	Cytotoxicity against human PBMC assessed as inhibition of cell viability after 72 hrs by MTT assay Cytotoxicity against human PBMC assessed as inhibition of cell viability after 72 hrs by MTT assay	[PMID: 24915876]
RAW264.7	IC₅₀	> 10 μM Compound: 19	Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production pretreated for 30 mins followed by LPS stimulation for 24 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production pretreated for 30 mins followed by LPS stimulation for 24 hrs by Griess assay	[PMID: 28499733]
U2OS	EC₅₀	63 μM Compound: 60961	Inhibition of the equilibrative nucleoside transporter (ENT1, SLC29A1) as assessed by GPCR-mediated changes in cell morphology using the impedance-based transporter activity through receptor activation (TRACT) assay (PubChem AID: 1745861) Inhibition of the equilibrative nucleoside transporter (ENT1, SLC29A1) as assessed by GPCR-mediated changes in cell morphology using the impedance-based transporter activity through receptor activation (TRACT) assay (PubChem AID: 1745861)	[PMID: 31551431]

体外研究
(In Vitro)

Adenosine (腺嘌呤核苷) 作用于四种 G 蛋白偶联受体：其中两种，A1 和 A3，主要与 Gi 家族 G 蛋白偶联；其中两个，A2A 和 A2B，主要像 G 蛋白一样与 G 偶联。这些受体被包括咖啡因在内的黄嘌呤所拮抗。通过这些受体，它影响许多细胞和器官，通常具有细胞保护功能^[2]。
Adenosine 是一种细胞外信号分子，由其前体分子 5'-三磷酸 Adenosine (ATP) 生成) 和 5'-单磷酸 Adenosine (AMP)^[3]。
Adenosine 是 ATP 的常见代谢产物，在高浓度下表现出细胞毒性作用。Adenosine (1.0-4.0 mM；12-24 小时) 抑制细胞活力并触发 HepG2 细胞内质网应激^[4]。
Adenosine 可诱导多种癌细胞凋亡。Adenosine (2.0 mM；12-24 小时) 在 HepG2 细胞中诱导自噬。在 HepG2 细胞系中，Adenosine 诱导的 AMPK/mTOR 通路激活部分阻断了 ER 应激并减少了凋亡细胞死亡^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

267.24

Formula

C₁₀H₁₃N₅O₄

CAS 号

58-61-7

性状

固体

颜色

White to off-white

中文名称

腺苷

结构分类

Others

初始来源

微生物

内源性代谢物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	1 year
	-20°C	6 months

溶解性数据

细胞实验：

DMSO 中的溶解度 : 33.33 mg/mL (124.72 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H₂O 中的溶解度 : ≥ 6.67 mg/mL (24.96 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.7420 mL	18.7098 mL	37.4195 mL
5 mM	0.7484 mL	3.7420 mL	7.4839 mL
10 mM	0.3742 mL	1.8710 mL	3.7420 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C储存时，请在1年内使用， -20°C储存时，请在6个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

请依序添加每种溶剂： PBS
Solubility: 6.67 mg/mL (24.96 mM); 澄清溶液; 超声助溶 (<60°C)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.96%

选择批次：

Data Sheet (644 KB) SDS (393 KB)

COA (291 KB) HNMR (132 KB) RP-HPLC (253 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Fredholm BB. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ. 2007;14(7):1315-1323. [Content Brief]

[2]. Borea PA, Gessi S, Merighi S, Vincenzi F, Varani K. Pharmacology of Adenosine Receptors: The State of the Art. Physiol Rev. 2018;98(3):1591-1625. [Content Brief]

[3]. Eltzschig HK. Adenosine: an old drug newly discovered. Anesthesiology. 2009;111(4):904-915. [Content Brief]

[4]. Zhou XT, et al. Inhibition of autophagy enhances adenosine induced apoptosis in human hepatoblastoma HepG2 cells. Oncol Rep. 2019;41(2):829-838. [Content Brief]

Adenosine 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	3.7420 mL	18.7098 mL	37.4195 mL	93.5489 mL
	5 mM	0.7484 mL	3.7420 mL	7.4839 mL	18.7098 mL
	10 mM	0.3742 mL	1.8710 mL	3.7420 mL	9.3549 mL
	15 mM	0.2495 mL	1.2473 mL	2.4946 mL	6.2366 mL
	20 mM	0.1871 mL	0.9355 mL	1.8710 mL	4.6774 mL
DMSO	25 mM	0.1497 mL	0.7484 mL	1.4968 mL	3.7420 mL
	30 mM	0.1247 mL	0.6237 mL	1.2473 mL	3.1183 mL
	40 mM	0.0935 mL	0.4677 mL	0.9355 mL	2.3387 mL
	50 mM	0.0748 mL	0.3742 mL	0.7484 mL	1.8710 mL
	60 mM	0.0624 mL	0.3118 mL	0.6237 mL	1.5591 mL
	80 mM	0.0468 mL	0.2339 mL	0.4677 mL	1.1694 mL
	100 mM	0.0374 mL	0.1871 mL	0.3742 mL	0.9355 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Adenosine (Synonyms: 腺苷; Adenine riboside; D-Adenosine)

Customer Review

Other Forms of Adenosine:

MCE 顾客使用本产品发表的 16 篇科研文献