1. Signaling Pathways
  2. Immunology/Inflammation
  3. PGE synthase

PGE synthase

PGE synthase (Prostaglandin E synthase), which converts cyclooxygenase (COX)-derived prostaglandin (PG) H2 to PGE2, occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions. Cytosolic PGES (cPGES) is a cytosolic protein that is constitutively expressed in a wide variety of cells and tissues and is associated with heat shock protein 90 (Hsp90). Membrane-associated PGES (mPGES), the expression of which is stimulus-inducible and is downregulated by anti-inflammatory glucocorticoids, is a perinuclear protein belonging to the microsomal glutathione S-transferase (GST) family. These two PGESs display distinct functional coupling with upstream COXs in cells; cPGES is predominantly coupled with the constitutive COX-1, whereas mPGES is preferentially linked with the inducible COX-2. Several cytosolic GSTs also have the capacity to convert PGH2 to PGE2 in vitro. Accumulating evidence has suggested that mPGES participates in various pathophysiological states in which COX-2 is involved, implying that mPGES represents a potential novel target for drug development.

PGE synthase 相关产品 (15):

Cat. No. Product Name Effect Purity
  • HY-B0890
    Zomepirac sodium salt Inhibitor 99.45%
  • HY-N0297
    Sinensetin Inhibitor 99.34%
  • HY-B0683
    Limaprost Agonist 99.95%
  • HY-13283
    MF63 Inhibitor 98.94%
    MF63是mPGES-1抑制剂,对猪mPGES-1和人mPGES-1的IC50分别为0.9 nM和1.3 nM。
  • HY-10582
    Flurbiprofen Inhibitor 99.85%
  • HY-108259
    HQL-79 Inhibitor >99.0%
    HQL-79 是一种有效、选择性、可口服的人造血前列腺素 D 合成酶 (hematopoietic prostaglandin D synthase (H-PGDS)) 抑制剂,高度选择性地抑制 PGD2 的合成,为抗过敏剂,对 H-PGDS 的 Kd 值为 0.8 μM,IC50 值为 6 μM。对 COX-1,COX-2,m-PGES 或 L-PGDS 等无作用。
  • HY-100864
    mPGES1-IN-3 Inhibitor
    mPGES1-IN-3 (Compound 17d) 是一种有效的选择性微粒体前列腺素 E2 合成酶-1 (mPGES-1) 抑制剂,抑制 mPGES-1 酶,IC50 为 8 nM,抑制 A549 细胞,IC50 为 16.24 nM。
  • HY-126134
    HPGDS inhibitor 2 Inhibitor
    HPGDS inhibitor 2 是一种高效选择性的造血前列腺素 D 合成酶 (H-PGDS) 抑制剂,IC50 值为 9.9 nM。
  • HY-B0550
    Bismuth Subsalicylate Inhibitor
    Bismuth Subsalicylate能抑制前列腺素G/H合酶1/2。
  • HY-12791
    hPGDS-IN-1 Inhibitor 99.82%
    hPGDS-IN-1是一种hPGDS抑制剂, 荧光偏振检测或EIA法测得IC50值为12 nM。
  • HY-30235A
    Benzydamine hydrochloride Inhibitor 98.79%
    Benzydamine hydrochloride 是前列腺素合成酶抑制剂,抗炎症,还报道有抗细菌活性。
  • HY-B0270
    Suprofen Inhibitor 99.44%
    Suprofen (TN-762) 是非甾体抗炎化合物,能抑制前列腺素合成。
  • HY-101587
    PGS-IN-1 Inhibitor 99.51%
    PGS-IN-1是有效的前列腺素合成酶 (prostaglandin synthetase) 抑制剂,IC50 值为0.28 μM;也可抑制5-脂肪氧合酶 (5-lipoxygenase) 的活性,IC50 值为 1.05 μM。
  • HY-B0336
    Pranoprofen Inhibitor 98.48%
  • HY-10439
    HPGDS inhibitor 1 Inhibitor 99.32%
    HPGDS inhibitor 1是造血前列腺素D合成酶(HPGDS)抑制剂,IC50为0.7 nM。
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