Bismuth Subsalicylate  (Synonyms: 次水杨酸铋; Bismuth oxysalicylate; Bismuth(III) salicylate basic)

Bismuth Subsalicylate is a potent and orally active antacid and anti-diarrheal agent. Bismuth Subsalicylate reduces inflammation/irritation of stomach and intestinal lining through inhibition of prostaglandin synthesis in vivo^[1]. Bismuth Subsalicylate is widely used for the research of diarrheal disorders, including indigestion, diarrhoea, nausea, et al^[1][2].

In the gastrointestinal tract, Bismuth Subsalicylate can be converted to salicylic acid and insoluble bismuth salts. Salicylic acid reduces inflammation/irritation of stomach and intestinal lining through inhibition of prostaglandin G/H synthase 1/2^[1].
Bismuth Subsalicylate (oral gavage; 100 mg/kg-350 mg/kg) significantly decreases castor oil-induced movement of a charcoal test meal along the small intestine of the mouse and rat and also decreases both the fecal output (dry or wet weight) and the frequency of diarrhea in mice^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

362.09

C₇H₅BiO₄

14882-18-9

固体

White to off-white

次水杨酸铋；碱式水杨酸铋；次柳酸铋水杨酸铋；次柳酸铋；亚水杨酸铋

Room temperature in continental US; may vary elsewhere.

• [1]. Bismuth subsalicylate. Drug.bank

  [2]. Alejandra Orona-Ortiz, et al. Mucoadhesive effect of Curcuma longa extract and curcumin decreases the ranitidine effect, but not bismuth subsalicylate on ethanol-induced ulcer model. Sci Rep. 2019 Nov 12;9(1):16622.  [Content Brief]