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Progesterone Receptor

Progesterone receptor (PR) is a protein found inside cells, which is activated by the steroid hormone progesterone. In humans, PR is encoded by a single PGR gene residing on chromosome 11q22, it has two main forms, A and B, that differ in their molecular weight. Progesterone is necessary to induce the progesterone receptors. When no binding hormone is present the carboxyl terminal inhibits transcription. Binding to a hormone induces a structural change that removes the inhibitory action. Progesterone antagonists prevent the structural reconfiguration. After progesterone binds to the receptor, restructuring with dimerization follows and the complex enters the nucleus and binds to DNA. There transcription takes place, resulting in formation of messenger RNA that is translated by ribosomes to produce specific proteins. Progesterone receptor plays a central role in diverse reproductive events associated with establishment and maintenance of pregnancy, alveolar development in the breast and sexual behavior.

Progesterone Receptor 相关产品 (21):

Cat. No. Product Name Effect Purity
  • HY-13683
    Mifepristone Antagonist 98.67%
    Mifepristone是黄体酮受体 (PR) 和糖皮质激素受体 (GR) 拮抗剂,体外实验中的 IC50 值分别为0.2 nM 和2.6 nM。
  • HY-N0437
    Progesterone Agonist 99.46%
    Progesterone是一种类固醇激素,可调节月经周期,对怀孕很重要。
  • HY-B0469
    Medroxyprogesterone acetate Agonist 99.82%
    Medroxyprogesterone醋酸盐是孕酮受体激动剂,是合成的人激素孕酮变体。
  • HY-16508
    Ulipristal acetate Antagonist 99.93%
    Ulipristal acetate 是一种选择性黄体酮受体调节剂 (selective progesterone receptor modulator),用于治疗良性妇科疾病如子宫肌瘤。
  • HY-B0257A
    Dydrogesterone Agonist 99.98%
    Dydrogesterone 是口服活性的孕激素,可作用于孕酮缺乏相关疾病。
  • HY-W011890
    Cridanimod Activator 99.82%
    Cridanimod 是一种有效的孕酮受体 (PR) 激活剂,通过诱导 IFNαIFNβ 的表达可显着增加 PR 的表达。Cridanimod 是一种小分子免疫调节剂和干扰素诱导剂。
  • HY-105634A
    Nomegestrol acetate Agonist
    Nomegestrol acetate 是一种有效的高选择性孕激素,可用作孕酮受体 (progesterone receptor) 的完全激动剂,与其他类固醇受体 (包括雄激素和糖皮质激素受体) 没有或具有很低的结合力。
  • HY-119433
    Asoprisnil Modulator 98.30%
    Asoprisnil (J867) 是一种选择性孕激素受体 (progesterone receptor) 调节剂,对动物和人类中各种孕酮靶向组织具有混合的孕酮激动剂和拮抗剂作用。
  • HY-13676
    Megestrol Acetate Inhibitor 99.81%
    Megestrol醋酸盐能抑制HegG2,IC50为260 μM。
  • HY-B0111
    Drospirenone Agonist 98.45%
    Drospirenone(Dihydrospirorenone)是合成的孕酮,是spironolactone的类似物。
  • HY-B0521
    Altrenogest Agonist 99.80%
    Altrenogest (Allyltrenbolone) 是孕激素,结构与trenbolone相关,能作用于孕激素受体。
  • HY-B0084
    Dienogest Agonist 99.70%
    Dienogest(STS-557)是孕酮受体激动剂,有口服的子宫内膜活性,可作用于子宫内膜异位。
  • HY-15606
    Tanaproget Agonist 98.99%
    Tanaproget (NSP-989) 是新型非甾体孕酮受体激动剂。
  • HY-B1095
    Chlormadinone acetate Agonist >98.0%
    Chlormadinone醋酸盐是一种类固醇孕激素, 具有抗雄激素和抗雌激素特性。
  • HY-12516
    Desogestrel Agonist 99.33%
    Desogestrel(Org-2969)是第三代孕激素类似物,许多口服避孕制剂中含有。
  • HY-B1710
    Norethindrone acetate 99.33%
    Norethindrone acetate是FDA批准用于治疗子宫内膜异位症,由异常激素水平引起的子宫出血症和继发性闭经的女性孕激素。
  • HY-B1089
    Ethynodiol diacetate Agonist 98.02%
    Ethynodiol diacetate是一种甾体孕激素, 用作激素避孕药, 具有相对较少或没有雄激素效果, 而具有显著雌激素作用。
  • HY-13071
    Nestoron Agonist 99.41%
    Nestoron (Elcometrine) 是一种 19-norprogesterone 衍生物,对 progesterone receptors 具有高亲和力和选择性,是一种高度选择性和有效的孕激素,可用作激素避孕药。
  • HY-B0110
    Gestodene Agonist 99.86%
    Gestodene(SHB 331;WL 70)是孕激素类避孕药。
  • HY-105634
    Nomegestrol Agonist
    Nomegestrol 是一种有效的,可口服的孕酮,为选择性的孕酮受体 (progesterone receptor) 完全激动剂,对大鼠子宫孕酮受体的 Kd 值为 5.44 nM,具有很强的抗雌性激素活性,适度的抗雄性激素活性。
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