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Progesterone Receptor

Progesterone receptor (PR) is a protein found inside cells, which is activated by the steroid hormone progesterone. In humans, PR is encoded by a single PGR gene residing on chromosome 11q22, it has two main forms, A and B, that differ in their molecular weight. Progesterone is necessary to induce the progesterone receptors. When no binding hormone is present the carboxyl terminal inhibits transcription. Binding to a hormone induces a structural change that removes the inhibitory action. Progesterone antagonists prevent the structural reconfiguration. After progesterone binds to the receptor, restructuring with dimerization follows and the complex enters the nucleus and binds to DNA. There transcription takes place, resulting in formation of messenger RNA that is translated by ribosomes to produce specific proteins. Progesterone receptor plays a central role in diverse reproductive events associated with establishment and maintenance of pregnancy, alveolar development in the breast and sexual behavior.

Progesterone Receptor 相关产品 (18):

Cat. No. Product Name Effect Purity
  • HY-13683
    Mifepristone Antagonist 98.17%
    Mifepristone是黄体酮受体 (PR) 和糖皮质激素受体 (GR) 拮抗剂,体外实验中的 IC50 值分别为0.2 nM 和2.6 nM。
  • HY-N0437
    Progesterone Agonist 98.79%
  • HY-B0469
    Medroxyprogesterone (acetate) Agonist 99.82%
  • HY-16508
    Ulipristal acetate Antagonist 99.93%
    Ulipristal acetate 是一种选择性黄体酮受体调节剂 (selective progesterone receptor modulator),用于治疗良性妇科疾病如子宫肌瘤。
  • HY-B0257A
    Dydrogesterone Agonist 99.88%
    Dydrogesterone 是口服活性的孕激素,可作用于孕酮缺乏相关疾病。
  • HY-105634
    Nomegestrol Agonist
    Nomegestrol 是一种有效的,可口服的孕酮,为选择性的孕酮受体 (progesterone receptor) 完全抑制剂,对大鼠子宫孕酮受体的 Kd 值为 5.44 nM,具有很强的抗雌性激素活性,适度的抗雄性激素活性。
  • HY-13676
    Megestrol Acetate Inhibitor >98.0%
    Megestrol醋酸盐能抑制HegG2,IC50为260 μM。
  • HY-B0111
    Drospirenone Agonist 98.45%
  • HY-15606
    Tanaproget Agonist 98.99%
    Tanaproget (NSP-989) 是新型非甾体孕酮受体激动剂。
  • HY-B1710
    Norethindrone acetate 99.33%
    Norethindrone acetate是FDA批准用于治疗子宫内膜异位症,由异常激素水平引起的子宫出血症和继发性闭经的女性孕激素。
  • HY-B0521
    Altrenogest Agonist 99.80%
    Altrenogest (Allyltrenbolone) 是孕激素,结构与trenbolone相关,能作用于孕激素受体。
  • HY-B0084
    Dienogest Agonist 99.70%
  • HY-B1095
    Chlormadinone acetate Agonist >98.0%
    Chlormadinone醋酸盐是一种类固醇孕激素, 具有抗雄激素和抗雌激素特性。
  • HY-12516
    Desogestrel Agonist 99.33%
  • HY-B1089
    Ethynodiol diacetate Agonist 98.02%
    Ethynodiol diacetate是一种甾体孕激素, 用作激素避孕药, 具有相对较少或没有雄激素效果, 而具有显著雌激素作用。
  • HY-13071
    Nestoron Agonist 99.41%
    Nestoron(ST1435; Elcometrine)是19-norprogesterone衍生物,是孕酮受体高亲和力激动剂。
  • HY-B0110
    Gestodene Agonist 99.86%
    Gestodene(SHB 331;WL 70)是孕激素类避孕药。
  • HY-U00091
    Gestonorone Capronate
    Gestonorone Capronate是治疗良性前列腺肥大和子宫内膜癌的孕激素。
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