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Progesterone Receptor

Progesterone receptor (PR) is a protein found inside cells, which is activated by the steroid hormone progesterone. In humans, PR is encoded by a single PGR gene residing on chromosome 11q22, it has two main forms, A and B, that differ in their molecular weight. Progesterone is necessary to induce the progesterone receptors. When no binding hormone is present the carboxyl terminal inhibits transcription. Binding to a hormone induces a structural change that removes the inhibitory action. Progesterone antagonists prevent the structural reconfiguration. After progesterone binds to the receptor, restructuring with dimerization follows and the complex enters the nucleus and binds to DNA. There transcription takes place, resulting in formation of messenger RNA that is translated by ribosomes to produce specific proteins. Progesterone receptor plays a central role in diverse reproductive events associated with establishment and maintenance of pregnancy, alveolar development in the breast and sexual behavior.

Progesterone Receptor 相关产品 (30):

Cat. No. Product Name Effect Purity
  • HY-13683
    Mifepristone Antagonist 98.67%
    Mifepristone (RU486) 是黄体酮受体 (PR) 和糖皮质激素受体 (GR) 拮抗剂,体外实验中的 IC50 值分别为 0.2 nM 和 2.6 nM。
  • HY-N0437
    Progesterone Agonist 99.46%
  • HY-B0469
    Medroxyprogesterone acetate Agonist 99.82%
    Medroxyprogesterone acetate 是一种广泛使用的合成类固醇,与孕酮 (progesterone),雄激素 (androgen) 和糖皮质激素受体 (glucocorticoid receptors) 都有作用。
  • HY-W011890
    Cridanimod Activator 99.97%
    Cridanimod 是一种有效的孕酮受体 (PR) 激活剂,通过诱导 IFNαIFNβ 的表达可显着增加 PR 的表达。Cridanimod 是一种小分子免疫调节剂和干扰素诱导剂。
  • HY-B0257A
    Dydrogesterone Agonist 99.98%
    Dydrogesterone 是口服活性的孕激素,可作用于孕酮缺乏相关疾病。
  • HY-13676
    Megestrol acetate Inhibitor 99.81%
    Megestrol acetate 是具有口服活性的、合成孕激素。Megestrol acetate 可作为食欲刺激素,用于消瘦综合征如恶病质的研究。Megestrol acetate 可下调细胞核和细胞质雄激素受体 (androgen receptors) 的活性。Megestrol acetate 可用于 HIV 的研究并下调自噬分解代谢途径。
  • HY-16508
    Ulipristal acetate Antagonist 99.93%
    Ulipristal acetate (CDB-2914) 是一种口服活性的选择性孕酮受体 (progesterone receptor) 调节剂 (SPRM)。Ulipristal acetate 选择性地刺激平滑肌瘤细胞的自噬反应。Ulipristal acetate 具有用于良性妇科疾病的潜力,如子宫肌瘤。
  • HY-B0084
    Dienogest Agonist 99.83%
  • HY-15606
    Tanaproget Agonist 99.93%
    Tanaproget (NSP-989) 是新型非甾体孕酮受体激动剂。
  • HY-B0111
    Drospirenone Agonist 98.45%
  • HY-B0521
    Altrenogest Agonist 99.80%
    Altrenogest (Allyltrenbolone) 是孕激素,结构与trenbolone相关,能作用于孕激素受体。
  • HY-12516
    Desogestrel Agonist 99.70%
  • HY-B0648
    Medroxyprogesterone Agonist 99.43%
  • HY-B0891
    17-Hydroxyprogesterone Agonist 99.94%
    17-Hydroxyprogesterone (17-OHP)是一种内源性孕激素,在其他类固醇激素(包括糖皮质激素,雄激素,和雌激素)的生物合成中作为化学中间体。
  • HY-105634A
    Nomegestrol acetate Agonist 98.50%
    Nomegestrol acetate 是一种有效的高选择性孕激素,可用作孕酮受体 (progesterone receptor) 的完全激动剂,与其他类固醇受体 (包括雄激素和糖皮质激素受体) 没有或具有很低的结合力。
  • HY-14959
    Ulipristal Modulator >98.0%
    Ulipristal (CDB 3236) 是一种选择性的性孕酮受体 (progesterone receptor) 调节剂。Ulipristal 与孕激素受体结合,从而抑制 PR 介导的基因表达,并干扰生殖系统中孕激素的活性。
  • HY-B1095
    Chlormadinone acetate Agonist >98.0%
    Chlormadinone acetate 是一种类固醇孕激素, 具有抗雄激素和抗雌激素特性。
  • HY-A0285
    Norethisterone enanthate 99.50%
    Norethisterone enanthate 是一种长效的孕激素 (parenteral progestogen)。Norethisterone enanthate 也具有口服活性。
  • HY-B0257
    Levonorgestrel Agonist 99.13%
  • HY-B0554
    Norethindrone Agonist 99.57%
    Norethindrone (Norethisterone) 一种孕激素,用于研究子宫内膜异位症、由激素水平异常引起的子宫出血和继发性闭经。
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