1. Signaling Pathways
  2. Epigenetics
  3. Protein Arginine Deiminase

Protein Arginine Deiminase

Protein arginine deiminases (PADs) is a unique family of enzymes that catalyzes the hydrolysis of peptidyl-arginine to form peptidyl-citrulline on histones, fibrinogen, and other biologically relevant proteins. In humans, the PAD family is composed of five, calcium dependent isozymes (PADs 1-4 and 6), which share roughly 50% sequence similarity. PADs are found in a myriad of cell and tissue types, including the epidermis and uterus (PAD1), skeletal muscle, brain, inflammatory cells, several cancer cell lines, and secretory glands (PAD2), hair follicles and keratinocytes (PAD3), granulocytes and several types of cancer (PAD4), and oocytes and embryos (PAD6). PAD4, the best characterized isozyme, has also been shown to citrullinate a number of other proteins, including p300, ING4, RPS2, lamin C, and nucleophosmin.

Protein Arginine Deiminase 相关产品 (7):

Cat. No. Product Name Effect Purity
  • HY-100514
    GSK484 hydrochloride Inhibitor 98.00%
    GSK484 hydrochloride 是一种有效且可逆的肽酰基精氨酸脱亚氨酶 4 (PAD4) 抑制剂。GSK484 hydrochloride 高亲和力与 PAD4 结合,在不存在钙的情况下 IC50 为 50 nM。在 2 mM 钙的存在下,IC50 为 250 nM。
  • HY-100574A
    Cl-amidine hydrochloride Inhibitor
    Cl-amidine hydrochloride 是口服有效的 PAD 抑制剂,其对 PAD1、PAD3 和 PAD4 的 IC50 值分别为0.8 μM、 6.2 μM 和 5.9 μM。Cl-amidine hydrochloride 可诱导癌细胞的凋亡。Cl-amidine hydrochloride 可诱导 miR-16,引起细胞周期阻滞。Cl-Amidine hydrochloride 可阻断组蛋白 3 瓜氨酸化和中性粒细胞胞外陷阱的形成,并提高败血症小鼠的存活率。
  • HY-111347A
    BB-Cl-Amidine hydrochloride Inhibitor 99.98%
    BB-Cl-Amidine hydrochloride 是肽基精氨酸脱胺酶 (PAD) 的抑制剂。
  • HY-111347
    BB-Cl-Amidine Inhibitor
    BB-Cl-Amidine 是肽基精氨酸脱胺酶 (PAD) 的抑制剂。
  • HY-B1505
    Acefylline Activator 99.89%
    Acefylline (Theophyllineacetic acid),一种黄嘌呤衍生物,是腺苷受体拮抗剂。Acefylline 是蛋白质精氨酸脱亚氨酶 (PAD) 激活剂。Acefylline 也是一种支气管扩张剂,可以抑制大鼠肺 cAMP 磷酸二酯酶同工酶。
  • HY-137655
    BMS-P5 Inhibitor
    BMS-P5 是特异性的、具有口服活性的肽精氨酸二亚胺酶 4 (PAD4) 的抑制剂。BMS-P5 可阻断多发性骨髓瘤诱导的 NET 形成,并延缓肿瘤进程。
  • HY-137655A
    BMS-P5 free base Inhibitor
    BMS-P5 free base 是特异性的、具有口服活性的肽精氨酸二亚胺酶 4 (PAD4) 的抑制剂。BMS-P5 free base 可阻断多发性骨髓瘤诱导的 NET 形成,并延缓肿瘤进程。
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