1. Signaling Pathways
  2. Epigenetics
  3. Protein Arginine Deiminase

Protein Arginine Deiminase

Protein arginine deiminases (PADs) is a unique family of enzymes that catalyzes the hydrolysis of peptidyl-arginine to form peptidyl-citrulline on histones, fibrinogen, and other biologically relevant proteins. In humans, the PAD family is composed of five, calcium dependent isozymes (PADs 1-4 and 6), which share roughly 50% sequence similarity. PADs are found in a myriad of cell and tissue types, including the epidermis and uterus (PAD1), skeletal muscle, brain, inflammatory cells, several cancer cell lines, and secretory glands (PAD2), hair follicles and keratinocytes (PAD3), granulocytes and several types of cancer (PAD4), and oocytes and embryos (PAD6). PAD4, the best characterized isozyme, has also been shown to citrullinate a number of other proteins, including p300, ING4, RPS2, lamin C, and nucleophosmin.

Protein Arginine Deiminase 相关产品 (7):

Cat. No. Product Name Effect Purity
  • HY-100514
    GSK484 hydrochloride Inhibitor 98.00%
    GSK484 hydrochloride (GTPL8577) 是一种有效且可逆的肽酰基精氨酸脱亚氨酶 4 (PAD4) 抑制剂。GSK484 hydrochloride (GTPL8577) 高亲和力与 PAD4 结合,在不存在钙的情况下 IC50 为 50 nM。在 2 mM 钙的存在下,IC50 为 250 nM。
  • HY-111347A
    BB-Cl-Amidine hydrochloride Inhibitor 99.98%
    BB-Cl-Amidine hydrochloride 是肽基精氨酸脱胺酶 (PAD) 的抑制剂。
  • HY-100574A
    Cl-amidine hydrochloride Inhibitor
    Cl-amidine (hydrochloride) 是肽基精氨酸脱胺酶 (PAD) 的抑制剂,其对 PAD4 的 IC50 值为 5.9 μM。
  • HY-111347
    BB-Cl-Amidine Inhibitor
    BB-Cl-Amidine 是肽基精氨酸脱胺酶 (PAD) 的抑制剂。
  • HY-112903
    YW3-56 Inhibitor
    YW3-56 是有效的肽酰精氨酸脱亚胺酶 (PAD) 抑制剂,其对 PAD2 和 PAD4 的 IC50 值分别为 0.5-1 μM 和 1-2 μM。
  • HY-124586
    Streptonigrin Inhibitor
    Streptonigrin (Bruneomycin) 是由链霉菌 (Streptomyces flocculus) 产生的一种天然产物,具有抗肿瘤和抗菌活性。Streptonigrin 可作为 pan-PAD 抑制剂,抑制 PAD1PAD2PAD3PAD4IC50 分别为 48.3±34.2 μM,26.1±0.3 μM,0.43±0.03 μM 和 2.5±0.4 μM。
  • HY-100574
    Cl-amidine Inhibitor
    Cl-amidine 是 PAD 的抑制剂,其对 PAD4 的 IC50 值为 5.9 μM。
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