1. Epigenetics Anti-infection
  2. Protein Arginine Deiminase Antibiotic
  3. Streptonigrin

Streptonigrin  (Synonyms: Bruneomycin)

目录号: HY-124586 纯度: ≥99.0%
COA 产品使用指南

Streptonigrin (Bruneomycin) 是由链霉菌 (Streptomyces flocculus) 产生的一种天然产物,具有抗肿瘤和抗菌活性。Streptonigrin 可作为 pan-PAD 抑制剂,抑制 PAD1PAD2PAD3PAD4IC50 分别为 48.3±34.2 μM,26.1±0.3 μM,0.43±0.03 μM 和 2.5±0.4 μM。

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Streptonigrin Chemical Structure

Streptonigrin Chemical Structure

CAS No. : 3930-19-6

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1 mg ¥5200
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Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

WB

    Streptonigrin purchased from MCE. Usage Cited in: Sci Signal. 2023 Mar 14;16(776):eabq3362.  [Abstract]

    Streptonigrin (SUMOylation agonist; 2, 4, 8 μM; 48 h) markedly increases the amount of IL-33 protein SUMOylation in Huh7 cells transfected with wild-type IL-33.
    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Streptonigrin (Bruneomycin), a natural product produced by Streptomyces flocculus, possesses both anti-tumor and anti-bacterial activity. Streptonigrin acts as a pan-PAD inhibitor with IC50s of 48.3±34.2 µM, 26.1±0.3 µM, 0.43±0.03 µM, and 2.5±0.4 µM for PAD1, PAD2, PAD3, and PAD4, respectively[1].

    IC50 & Target

    Anti-bacterial[1]
    IC50: 48.3±34.2 µM (PAD1), 26.1±0.3 µM, (PAD2), 0.43±0.03 µM (PAD3), 2.5±0.4 µM (PAD4)[1]

    分子量

    506.46

    Formula

    C25H22N4O8

    CAS 号
    性状

    固体

    颜色

    Light brown to brown

    中文名称

    链黑菌素;链黑霉素

    结构分类
    初始来源

    Streptomyces flocculus

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    纯度 & 产品资料

    纯度: ≥99.0%

    参考文献
    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    目录号:
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