1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Renin

Renin (肾素)

Renin is a monospecific enzyme that catalyzes the rate-limiting step in the synthesis of angiotensin II. Amplified enzymatic activity and additional physiological effects occur when renin and pro-renin bind to the (pro)renin receptor. The classical site of renin expression and secretion is the renal juxtaglomerular cell, where its expression is tightly regulated by physiological cues.

Prorenin and renin bound to the (pro)renin receptor not only increase the catalytic conversion of angiotensinogen to angiotensin I (Ang I), but also upregulate the expression of profibrotic genes. Renin plays a critical role in the regulation of blood pressure, electrolyte homeostasis, mammalian renal development, and progression of fibrotic/hypertrophic diseases. Renin inhibitors represent an alternative to angiotensin-converting enzyme inhibitors (ACEI) for the treatment of hypertension.

Renin 相关产品 (4):

目录号 产品名 作用方式 纯度
  • HY-12177
    Aliskiren hemifumarate Inhibitor 98.98%
    Aliskiren hemifumarate (CGP 60536 hemifumarate) 是肾素的直接抑制剂,IC50为1.5 nM。
  • HY-N2115
    Araloside A Inhibitor
    Araloside A (Chikusetsusaponin IV) 是竹节参中的一种成分,对肾素 renin 具有低抑制活性,IC50 值为 77.4 μM。
  • HY-12176AS
    Aliskiren D6 Hydrochloride Inhibitor
    Aliskiren D6 Hydrochloride (CGP 60536 D6 Hydrochloride) 是 Aliskiren 氘代物。Aliskiren 是一种肾素抑制剂。
  • HY-P1572
    Handle region peptide, rat Antagonist
    Handle region peptide, rat 是肾素原 (prorenin) 受体拮抗剂,能够抑制糖尿病性肾病的进程,同时对眼部炎症有抵抗作用。
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