1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Renin

Renin (肾素)

Renin is a central hormone in the control of blood pressure and various other physiological functions. Renin is a hormone and an enzyme which chops the end off angiotensinogen, a circulating plasma peptide, thus creating thedecapeptide, angiotensin I. Angiotensin I is acted on by angiotensin converting enzyme (ACE), which chops another bit off to make the octapeptide, angiotensin II. Angiotensin II acts on the adrenal cortex to stimulate the release of aldosterone and aldosterone stimulates Na+ retention.

Renin is rate limiting in the production of angiotensin II (Ang II), a hormone that ultimately integrates cardiovascular and renal function in the control of blood pressure as well as salt and volume homeostasis. For instance, renin seems to be of vast importance for maintaining arterial blood pressure in the face of variations in salt intake: in mice, constant blood pressure is found during alterations in sodium intake, and this relies on controlling the activity of the renin-angiotensin system (RAS).

Renin 相关产品 (3):

Cat. No. Product Name Effect Purity
  • HY-12177
    Aliskiren hemifumarate Inhibitor 98.98%
    Aliskiren hemifumarate (CGP 60536 hemifumarate) 是肾素的直接抑制剂,IC50为1.5 nM。
  • HY-12176
    Aliskiren Inhibitor 99.16%
    Aliskiren(CGP 60536)是肾素抑制剂,IC50为1.5 nM。
  • HY-N2115
    Araloside A Inhibitor
    Araloside A (Chikusetsusaponin IV) 是竹节参中的一种成分,对肾素 renin 具有低抑制活性,IC50 值为 77.4 μM。
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