1. Signaling Pathways
  2. TGF-beta/Smad
  3. TGF-β Receptor
  4. ALK3 Isoform


BMPR1A (bone morphogenetic protein receptor type 1A) is also known as ALK3. Though some functions of ALK3 suggest similarity to ALK2, this protein has substantial sequence similarity with a different ALK family member, ALK6. Currently, it is known that many BMPs (BMP2, 4, 5, 6, 7, 8, 14, 15), GDF6, GDF7, and AMH can bind to ALK3 with some affinity to initiate differential downstream action. Global knockout of ALK3 is embryonic lethal. ALK3 is expressed in cells of the osteo lineage and bone marrow and is necessary for post-natal bone formation; as such, it is suggested that the main function of ALK3 is osteogenesis. Mice with conditional knockout of ALK3 in cartilage lack growth of the long bones, however this tissue gets replaced with bone-like tissue, supporting a role of ALK3 in cell fate and osteogenesis. Conditional deletion of Alk3 from osteoblasts produces a similar phenotype. These mice have increased bone formation in the trabecular bone, vertebrae, tail, and ribs, coupled with a reduction in osteoclastogenesis. Unlike ALK2, ALK3 has additional critical roles in development. Deletion of ALK3 in Xenopus results in dorsalized embryos and defects in the eye. Myocardial- and neural crest-specific knockouts of ALK3 show drastic developmental defects. Epicardial-specific deletion of ALK3 in mice results in atypical developmental of the atrioventricular sulcus and annulus fibrosis within the cardia. Additionally, when ALK3 is deleted early (at weaning or early adulthood) from the foregut, mice have improper gastric patterning, as well as a reduced number of parietal cells and increased number of endocrine cells.

目录号 产品名 作用方式 纯度
  • HY-13418A
    Dorsomorphin Inhibitor 99.91%
    Dorsomorphin (Compound C) 是一种选择性,ATP 竞争性的 AMPK 抑制剂 (在没有 AMP 的情况下,Ki 为 109 nM)。Dorsomorphin 选择性抑制 BMP I 型受体 ALK2ALK3ALK6。Dorsomorphin 还能够逆转 Urolithin A (HY-100599) 导致的自噬 (autophagy) 激活和抗炎作用。
  • HY-13418
    Dorsomorphin dihydrochloride Inhibitor 99.91%
    Dorsomorphin (Compound C) dihydrochloride 是一种有效,选择性和 ATP 竞争性的 AMPK 抑制剂,Ki 为 109 nM。Dorsomorphin dihydrochloride 通过靶向抑制 I 型受体 ALK2ALK3ALK6 来抑制 BMP 途径。Dorsomorphin dihydrochloride 还能够逆转 Urolithin A (HY-100599) 导致的自噬 (autophagy) 激活和抗炎作用。
  • HY-12071
    LDN193189 Inhibitor 99.48%
    LDN193189 是一种有效的选择性 BMP I 型受体抑制剂。LDN-193189 有效抑制 BMP I 型受体 ALK2ALK3 的转录活性,IC50 值分别为 5 nM 和 30 nM。LDN-193189 可用于骨形态发生蛋白信号传导的研究,例如进行性骨化纤维发育不良。
  • HY-12071A
    LDN193189 Tetrahydrochloride Inhibitor 99.86%
    LDN193189 Tetrahydrochloride 是一种选择性的 BMP I 型受体抑制剂,抑制 ALK2ALK3IC50 分别为 5 nM 和 30 nM。对 ALK4ALK5ALK7 的作用效果弱 (IC50≥500 nM)。
  • HY-15897


    Inhibitor 99.70%
    LDN-212854 是一种骨形态发生蛋白 (BMP) 抑制剂,可有效抑制 ALK2 (IC50: 1.3 nM)。LDN-212854 还可抑制 ALK1 (IC50: 2.40 nM)。LDN-212854 可用于研究进行性骨化纤维发育不良和癌症,如肝细胞癌 (HCC)。
  • HY-12274
    ML347 Inhibitor 99.89%
    ML347 (DN193719) 是一种高选择性的 ALK1/ALK2 抑制剂。ML347 对ALK1 和 ALK2IC50分别为 46 和 32 nM,是 ALK3 的 300 倍以上。ML347 能够阻断 TGF-β1 对 Smad1/5 的磷酸化。
  • HY-123900
    AZ12799734 Inhibitor 98.07%
    AZ12799734 是一种选择性的、具有口服活性的 TGFBR1 激酶抑制剂, IC50 为 47 nM。 AZ12799734 也是一种 BMPTGFβ 抑制剂。
目录号 产品名 / 同用名 种属 表达系统