1. Signaling Pathways
  2. GPCR/G Protein
  3. TSH Receptor

TSH Receptor

The thyrotropin receptor (TSHR), one of the primary antigens in autoimmune thyroid disease, is a target of both antigen-specific T cells and antibodies in patients with this condition. Autoantibodies to the TSHR (TSHR-Ab) act as thyroid stimulating factor (TSH) agonists in autoimmune hyperthyroidism (Robert Graves disease) but as TSH antagonists in autoimmune hypothyroidism (Hashimoto thyroiditis). The TSHR antigen is primarily expressed in the epithelial cells of the thyroid follicles, but TSHR mRNA and protein have been reported in a variety of cell types, some of which show evidence of receptor activity.

TSH receptor (TSHR) plays an important role in the pathogenesis of thyroid disease, a TSHR antagonist could be a novel treatment.

TSH, acting through the TSH receptor, is the major stimulator of thyroid cell growth, differentiation and function.

TSH Receptor 相关产品 (7):

Cat. No. Product Name Effect Purity
  • HY-12381
    ML224 Inhibitor 99.12%
    ML224(NCGC00242364; ANTAG3)是促甲状腺激素受体TSHR反激动剂,IC50值为2.3uM。
  • HY-114116
    ML-109 Agonist
    ML-109 是有效的、促甲状腺激素受体 (TSHR) 的全激动剂,其 EC50 值为 40 nM。
  • HY-129995A
    TSHR antagonist S37a Antagonist
    TSHR antagonist S37a 是一个高选择性的促甲状腺激素受体 TSHR 拮抗剂,具有治疗格雷夫斯眼窝病的潜力 。
  • HY-124867
    D3-βArr Modulator 99.48%
    D3-βArr 是一种促甲状腺激素受体正变构调节剂,通过促甲状腺激素受体直接激活启动 β-Arr 1 的易位,并增强促甲状腺激素介导的体外成骨细胞分化。
  • HY-129995B
    TSHR antagonist S37 Antagonist
    TSHR antagonist S37 是一种选择性、竞争性的 TSHR 拮抗剂。TSHR antagonist S37 是 TSHR antagonist S37a 的外消旋体。
  • HY-18286
    NCGC00229600 Antagonist
    NCGC00229600 是 TSHR 的变构反向激动剂。NCGC00229600 抑制 TSH 和刺激在 Graves 病中内源表达的 TSHRs 的抗体激活。
  • HY-100271
    Org41841 Agonist
    ORG41841 是促黄体激素/绒毛膜促性腺激素受体 (LHCGR) 和促甲状腺激素受体 (TSHR) 的部分激动剂,其 EC50 值分别为 0.2 和 7.7 μM。
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