1. GPCR/G Protein
  2. TSH Receptor
  3. Org41841

Org41841 

目录号: HY-100271 纯度: 99.46%
产品使用指南

ORG41841 是促黄体激素/绒毛膜促性腺激素受体 (LHCGR) 和促甲状腺激素受体 (TSHR) 的部分激动剂,其 EC50 值分别为 0.2 和 7.7 μM。

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Org41841 Chemical Structure

Org41841 Chemical Structure

CAS No. : 301847-37-0

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥4180
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5 mg ¥3800
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10 mg ¥6000
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25 mg ¥12500
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100 mg   询价  

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  • 生物活性

  • 实验参考方法

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  • 参考文献

生物活性

Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively.

IC50 & Target

EC50: 0.2 μM (LHCGR), 7.7 μM (TSHR)[1]

体外研究
(In Vitro)

Functional assays demonstrate that Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively. Treatment of L570F with Org41841 reveals an improved EC50 of 800 nM. M9 responds to Org41841 with an improved EC50 of 2700 nM and a greatly improved efficacy for signaling to 99% of the maximal value observed for thyroid-stimulating hormone (TSH) stimulation of thyroid-stimulating hormone receptor (TSHR)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

402.53

Formula

C19H22N4O2S2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (248.43 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4843 mL 12.4214 mL 24.8429 mL
5 mM 0.4969 mL 2.4843 mL 4.9686 mL
10 mM 0.2484 mL 1.2421 mL 2.4843 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
Kinase Assay
[1]

Transfected cells are cultured for 48 h before incubation for 1 h in serum-free Dulbecco's modified Eagle's medium containing 1 mM 3-isobutyl-1-methylxanthine and bovine thyroid-stimulating hormone (TSH) (0 to 1.8 μM) or human LH (0.1 to 1000 ng) or Org41841 (0 to100 μM) in a humidified 5% CO2 incubator. Following aspiration of the medium, cells are lysed using lysis buffer 1 of the cAMP Biotrak Enzymeimmunoassay System. The cAMP content of the cell lysate is determined and data are analyzed[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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Org41841
目录号:
HY-100271
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