1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Tryptophan Hydroxylase

Tryptophan Hydroxylase (色氨酸羟化酶)

Tryptophan hydroxylase (TPH) is a rate-limiting enzyme of serotonin (5-hydroxytryptamine) synthesis. TPH catalyzes the rate-limiting step in 5-HT biosynthesis. TPH exists as two isoforms, TPH1 and TPH2, which are encoded on two independent genes. TPH1 is mainly synthesized by enterochromaffin cells in the gut, whereas TPH2 is produced by serotonergic neurons in the central nervous system and by enteric neurons in the gut. TPH1 is the primary form and expresses earlier in neural development.

Tryptophan Hydroxylase 相关产品 (3):

Cat. No. Product Name Effect Purity
  • HY-B1368
    Fenclonine Inhibitor 99.90%
    Fenclonine 是有效的色氨酸羟化酶 (Trp) 的不可逆抑制剂,色氨酸羟化酶是 5-羟色胺生物合成的限速酶。
  • HY-23460A
    4-Ethynyl-L-phenylalanine hydrochloride Inhibitor 99.42%
    4-Ethynyl-L-phenylalanine hydrochloride 是一种选择性、可逆、高效、竞争性的色氨酸羟化酶 (TPH) 抑制剂。4-Ethynyl-L-phenylalanine hydrochloride 相对于底物色氨酸具有竞争性作用,Ki 值为 32.6 μM。4-Ethynyl-L-phenylalanine hydrochloride 能选择性和可逆地抑制 5- 羟色胺的生物合成。
  • HY-23460
    4-Ethynyl-L-phenylalanine Inhibitor 98.25%
    4-Ethynyl-L-phenylalanine 是一种选择性、可逆、高效、竞争性的色氨酸羟化酶 (TPH) 抑制剂。4-Ethynyl-L-phenylalanine 相对于底物色氨酸具有竞争性作用,Ki 值为 32.6 μM。4-Ethynyl-L-phenylalanine 能选择性和可逆地抑制 5- 羟色胺的生物合成。
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