1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Tryptophan Hydroxylase

Tryptophan Hydroxylase

Thrombin is a serine protease that in humans is encoded by the F2 gene. Thrombin is an intriguing coagulation protease demonstrating an array of effects on endothelial cells, vascular smooth muscle cells (VSMC), monocytes, and platelets, all of which are involved in the pathophysiology of atherosclerosis. There is mounting evidence that thrombin acts as a powerful modulator of many processes like regulation of vascular tone, permeability, migration and proliferation of VSMC, recruitment of monocytes into the atherosclerotic lesions, induction of diverse pro-inflammatory markers, and all of these are related to the progression of cardiovascular disease. Recent studies in transgenic mice models indicate that the deletion of the natural thrombin inhibitor heparin cofactor II promotes an accelerated atherogenic state. The combined evidence points to thrombin as a pivotal contributor to vascular pathophysiology.

Tryptophan Hydroxylase 相关产品 (9):

Cat. No. Product Name Effect Purity
  • HY-13055B
    Telotristat Inhibitor 99.46%
    Telotristat (LP-778902) 是一种有效的色氨酸羟化酶 (tryptophan hydroxylase) 抑制剂,在体内的 IC50 值为0.028 μM。
  • HY-B1368
    Fenclonine Inhibitor 99.10%
    Fenclonine 是一种医药中间体。
  • HY-13055A
    Telotristat ethyl Inhibitor 99.68%
    Telotristat ethyl (LX1606) 是一种可口服的色氨酸羟化酶抑制剂,能够减少血清素的产生。
  • HY-13041
    LX-1031 Inhibitor 99.55%
    LX-1031 是一种有效的,可口服的 tryptophan 5-hydroxylase (TPH) 抑制剂,能够减少5-羟色胺的合成。
  • HY-15849
    LP-533401 Inhibitor >98.0%
  • HY-101124
    Rodatristat ethyl Inhibitor
    Rodatristat ethyl (KAR5585) 是一种一流的口服的 tryptophan hydroxylase 1 (TPH1) 抑制剂,具有体外纳摩尔浓度,可降低 5-hydroxytryptamine (5-HT) 的水平并显着降低肺动脉高压 (PAH),
  • HY-120083
    Rodatristat Inhibitor
    Rodatristat (KAR5417) 是一种有效的 tryptophan hydroxylase 1 (TPH1)TPH2 抑制剂,其 IC50 值分别为 33 nM 和 7 nM,并显著降低小鼠肠道中的血清素 (5-HT) 水平。
  • HY-13055
    Telotristat etiprate Inhibitor 99.77%
    Telotristat etiprate (LX1606 Hippurate) 是色氨酸羟化酶抑制剂,能够减少血清素的产生。
  • HY-15849A
    LP-533401 hydrochloride Inhibitor 98.09%
    LP-533401 hydrochloride 是色氨酸羟化酶 1 (tryptophan hydroxylase 1) 抑制剂,可以调节肠道中血清素的产生。
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