1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Tryptophan Hydroxylase

Tryptophan Hydroxylase

Tryptophan hydroxylase (TPH) is a rate-limiting enzyme of serotonin (5-hydroxytryptamine) synthesis. TPH catalyzes the rate-limiting step in 5-HT biosynthesis. TPH exists as two isoforms, TPH1 and TPH2, which are encoded on two independent genes. TPH1 is mainly synthesized by enterochromaffin cells in the gut, whereas TPH2 is produced by serotonergic neurons in the central nervous system and by enteric neurons in the gut. TPH1 is the primary form and expresses earlier in neural development.

Tryptophan Hydroxylase 相关产品 (9):

Cat. No. Product Name Effect Purity
  • HY-13055B
    Telotristat Inhibitor 98.91%
    Telotristat (LP-778902) 是一种有效的色氨酸羟化酶 (tryptophan hydroxylase) 抑制剂,在体内的 IC50 值为0.028 μM。
  • HY-B1368
    Fenclonine Inhibitor 99.90%
    Fenclonine 是一种医药中间体。
  • HY-13055A
    Telotristat ethyl Inhibitor 99.68%
    Telotristat ethyl (LX1606) 是一种可口服的色氨酸羟化酶抑制剂,能够减少血清素的产生。
  • HY-13055
    Telotristat etiprate Inhibitor 99.77%
    Telotristat etiprate (LX1606 Hippurate) 是色氨酸羟化酶抑制剂,能够减少血清素的产生。
  • HY-13041
    LX-1031 Inhibitor 99.55%
    LX-1031 是一种有效的,可口服的 tryptophan 5-hydroxylase (TPH) 抑制剂,能够减少5-羟色胺的合成。
  • HY-23460A
    4-Ethynyl-L-phenylalanine hydrochloride Inhibitor
    4-Ethynyl-L-phenylalanine hydrochloride 是一种选择性、可逆、高效、竞争性的色氨酸羟化酶 (TPH) 抑制剂。4-Ethynyl-L-phenylalanine hydrochloride 相对于底物色氨酸具有竞争性作用,Ki 值为 32.6 μM。4-Ethynyl-L-phenylalanine hydrochloride 能选择性和可逆地抑制 5- 羟色胺的生物合成。
  • HY-23460
    4-Ethynyl-L-phenylalanine Inhibitor
    4-Ethynyl-L-phenylalanine 是一种选择性、可逆、高效、竞争性的色氨酸羟化酶 (TPH) 抑制剂。4-Ethynyl-L-phenylalanine 相对于底物色氨酸具有竞争性作用,Ki 值为 32.6 μM。4-Ethynyl-L-phenylalanine 能选择性和可逆地抑制 5- 羟色胺的生物合成。
  • HY-15849A
    LP-533401 hydrochloride Inhibitor 98.09%
    LP-533401 hydrochloride 是色氨酸羟化酶 1 (tryptophan hydroxylase 1) 抑制剂,可以调节肠道中血清素的产生。
  • HY-15849
    LP-533401 Inhibitor >98.0%
Isoform Specific Products

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