1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Tryptophan Hydroxylase

Tryptophan Hydroxylase (色氨酸羟化酶)

Tryptophan hydroxylase (TPH) is a rate-limiting enzyme of serotonin (5-hydroxytryptamine) synthesis. TPH catalyzes the rate-limiting step in 5-HT biosynthesis. TPH exists as two isoforms, TPH1 and TPH2, which are encoded on two independent genes. TPH1 is mainly synthesized by enterochromaffin cells in the gut, whereas TPH2 is produced by serotonergic neurons in the central nervous system and by enteric neurons in the gut. TPH1 is the primary form and expresses earlier in neural development.

Tryptophan Hydroxylase 相关产品 (4):

Cat. No. Product Name Effect Purity
  • HY-B1368
    Fenclonine Inhibitor
    Fenclonine 是有效的色氨酸羟化酶 (Trp) 的不可逆抑制剂,色氨酸羟化酶是 5-羟色胺生物合成的限速酶。
  • HY-23460A
    p-Ethynylphenylalanine hydrochloride Inhibitor 99.42%
    p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) 是一种高效、选择性的,可逆、竞争性的色氨酸羟化酶 (TPH) 抑制剂,其 Ki 值为 32.6 μM。
  • HY-23460
    p-Ethynylphenylalanine Inhibitor 98.25%
    p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) 是一种高效、选择性的,可逆、竞争性的色氨酸羟化酶 (TPH) 抑制剂,其 Ki 值为 32.6 μM。
  • HY-101456
    PCPA methyl ester hydrochloride Inhibitor
    PCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) 是一种可逆的色氨酸羟化酶 (tryptophan hydroxylase) 抑制剂,是 5-羟色胺 (5-HT) 合成抑制剂。PCPA methyl ester hydrochloride 可穿过血脑屏障,并降低 5-HT 的中枢利用率。
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