1. Metabolic Enzyme/Protease
  2. Tryptophan Hydroxylase
  3. 4-Ethynyl-L-phenylalanine hydrochloride

4-Ethynyl-L-phenylalanine hydrochloride 

目录号: HY-23460A
产品使用指南

4-Ethynyl-L-phenylalanine hydrochloride 是一种选择性、可逆、高效、竞争性的色氨酸羟化酶 (TPH) 抑制剂。4-Ethynyl-L-phenylalanine hydrochloride 相对于底物色氨酸具有竞争性作用,Ki 值为 32.6 μM。4-Ethynyl-L-phenylalanine hydrochloride 能选择性和可逆地抑制 5- 羟色胺的生物合成。

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4-Ethynyl-L-phenylalanine hydrochloride Chemical Structure

4-Ethynyl-L-phenylalanine hydrochloride Chemical Structure

CAS No. : 188640-63-3

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥770 In-stock
50 mg ¥700 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Description

4-Ethynyl-L-phenylalanine hydrochloride is a selective, reversible, potent and competitive inhibitor of tryptophan hydroxylase (TPH). 4-Ethynyl-L-phenylalanine hydrochloride is a competitive inhibitor with regard to the substrate tryptophan, with a Ki of 32.6 μM. 4-Ethynyl-L-phenylalanine hydrochloride selectively and reversibly inhibits the biosynthesis of serotonin[1].

IC50 & Target

Ki: 32.6 μM (TPH)[1]

In Vivo

4-Ethynyl-L-phenylalanine hydrochloride (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue[1].
4-Ethynyl-L-phenylalanine hydrochloride is not inhibiting the aromatic amino acid decarboxylase[1].
4-Ethynyl-L-phenylalanine hydrochloride has a low affinity for various recombinant 5-HT receptors[1].

Animal Model: Male Sprague-Dawley rats (200 g)[1]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection
Result: Decreased in 5-HT and 5-HIAA levels in the rat midbrain.
Molecular Weight

225.67

Formula

C₁₁H₁₂ClNO₂

CAS No.

188640-63-3

SMILES

N[C@@H](CC1=CC=C(C#C)C=C1)C(O)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

Methanol : 125 mg/mL (553.91 mM; Need ultrasonic)

DMSO : 100 mg/mL (443.12 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4312 mL 22.1562 mL 44.3125 mL
5 mM 0.8862 mL 4.4312 mL 8.8625 mL
10 mM 0.4431 mL 2.2156 mL 4.4312 mL
*

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储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。 -80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

References
  • 摩尔计算器

  • 稀释计算器

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Keywords:

4-Ethynyl-L-phenylalanineTryptophan HydroxylasetryptophanhydroxylaseTPHserotonin5-HT5-HIAAInhibitorinhibitorinhibit

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产品名称:
4-Ethynyl-L-phenylalanine hydrochloride
目录号:
HY-23460A
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