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  3. Galectin

Galectin (半乳糖凝集素)

Galectins comprise a family of soluble β-galactoside binding proteins, which regulate key biological processes including cell growth, differentiation, apoptosis, and immune responses.

Sixteen galectin genes have been identified in animal kingdoms, 12 of which are expressed in humans. Galectins are usually classified into three groups based on their structure: (i) prototypical galectins (galectin-1 (Gal1), Gal2, Gal5, Gal7, Gal10, Gal11, Gal 13, Gal14, and Gal15), characterized by a single CRD, which can act as monomers or form homodimers; (ii) the chimeric galectin Gal3 (the only member of this class), with a single CRD and a large amino-terminal domain that facilitates the formation of oligomers; (iii) the tandem repeat galectins, with two CRDs that are linked through a small peptide domain; this group includes Gal4, Gal6, Gal8, Gal9, and Gal12. Recently, Galectins have been implicated as major therapeutic determinants that confer sensitivity or resistance to a wide range of anticancer modalities including chemotherapy, radiotherapy, targeted therapies, antiangiogenic therapies, and immunotherapies.

Galectin 相关产品 (7):

目录号 产品名 作用方式 纯度
  • HY-114409
    GB1107 Inhibitor 99.73%
    GB1107 是一个有效的、选择性的、具有口服活性的 半乳糖凝集素 3 (Gal-3) 的抑制剂,其对人Gal-3的Kd 值为 37 nM。GB1107 可降低人和小鼠肺腺癌的生长并抑制转移。
  • HY-19756
    OTX008 Inhibitor ≥98.0%
    OTX008 是一个半乳糖凝集素 1 (galectin-1) 的选择性抑制剂。
  • HY-130208


    Inhibitor ≥99.0%
    Thiodigalactoside (TDG) 是一种具有口服活性的,有效的半乳凝素 (GAL) 抑制剂,对于 GAL-1 和 GAL-3 的 Kd 值分别为 24 μM,49 μM。Thiodigalactoside 是一种不可代谢的二糖,具有抗炎和抗癌活性。Thiodigalactoside 可显着降低饮食诱发的肥胖大鼠的体重增加。
  • HY-P1592A
    G3-C12 TFA 99.45%
    G3-C12 (TFA) 是 galectin-3 结合肽,Kd 值为 88 nM,具有抗肿瘤活性。
  • HY-P1592
    G3-C12 99.44%
    G3-C12 是 galectin-3 结合肽,Kd 值为 88 nM,具有抗肿瘤活性。
  • HY-144313
    Galectin-3-IN-2 Inhibitor
    Galectin-3-IN-2 (Compound 9) 是一种有效的多价半乳糖凝集素-3 (Gal-3; IC50=8.3 μM) 抑制剂。Galectin-3 参与许多与癌症相关的代谢过程。
  • HY-144312
    Galectin-3-IN-1 Inhibitor
    Galectin-3-IN-1 (Compound 1) 是一种有效的多价半乳糖凝集素-3 (Gal-3) 抑制剂。Galectin-3 参与许多与癌症相关的代谢过程。
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