1. Signaling Pathways
  2. Immunology/Inflammation
  3. Galectin

Galectin (半乳糖凝集素)

Galectins comprise a family of soluble β-galactoside binding proteins, which regulate key biological processes including cell growth, differentiation, apoptosis, and immune responses.

Sixteen galectin genes have been identified in animal kingdoms, 12 of which are expressed in humans. Galectins are usually classified into three groups based on their structure: (i) prototypical galectins (galectin-1 (Gal1), Gal2, Gal5, Gal7, Gal10, Gal11, Gal 13, Gal14, and Gal15), characterized by a single CRD, which can act as monomers or form homodimers; (ii) the chimeric galectin Gal3 (the only member of this class), with a single CRD and a large amino-terminal domain that facilitates the formation of oligomers; (iii) the tandem repeat galectins, with two CRDs that are linked through a small peptide domain; this group includes Gal4, Gal6, Gal8, Gal9, and Gal12. Recently, Galectins have been implicated as major therapeutic determinants that confer sensitivity or resistance to a wide range of anticancer modalities including chemotherapy, radiotherapy, targeted therapies, antiangiogenic therapies, and immunotherapies.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-114409
    GB1107 Inhibitor 99.90%
    GB1107 是一个有效的、选择性的、具有口服活性的 半乳糖凝集素 3 (Gal-3) 的抑制剂,其对人Gal-3的Kd 值为 37 nM。GB1107 可降低人和小鼠肺腺癌的生长并抑制转移。
    GB1107
  • HY-19756
    OTX008 Inhibitor 99.09%
    OTX008 是一个半乳糖凝集素 1 (galectin-1) 的选择性抑制剂。
    OTX008
  • HY-147041
    Selvigaltin Inhibitor 98.72%
    Selvigaltin (GB1211) 是一种具有口服活性的 galectin-3 (Gal-3) 抑制剂。
    Selvigaltin
  • HY-19940
    Olitigaltin Inhibitor 99.22%
    TD139是吸入式的半乳凝素-3 (galectin-3) 抑制剂,Kd 值为14 nM。
    Olitigaltin
  • HY-130208
    Thiodigalactoside

    硫代半乳糖苷

    Inhibitor ≥99.0%
    Thiodigalactoside (TDG) 是一种具有口服活性的,有效的半乳凝素 (GAL) 抑制剂,对于 GAL-1 和 GAL-3 的 Kd 值分别为 24 μM,49 μM。Thiodigalactoside 是一种不可代谢的二糖,具有抗炎和抗癌活性。Thiodigalactoside 可显着降低饮食诱发的肥胖大鼠的体重增加。
    Thiodigalactoside
  • HY-157822
    Galectin-8-IN-2 Inhibitor
    Galectin-8-IN-2 (Compound 10) 是一种半乳糖凝集素-8N 抑制剂。
    Galectin-8-IN-2
  • HY-157824
    6Lac[6]Met Inhibitor
    6Lac[6]Met 是一种半乳糖凝集素 4 抑制剂,IC50 值为 5 μM。
    6Lac[6]Met
  • HY-W150340
    β-Lactose

    β-乳糖

    Inhibitor ≥98.0%
    β-Lactose 是一种双糖,常见于牛奶和乳制品中。它由两个单糖组成,葡萄糖和半乳糖,通过β-糖苷键连接。β-Lactose 在食品工业中有多种应用,特别是作为甜味剂和填充剂。此外,它还可用作参与乳糖代谢的酶的底物,以及研究碳水化合物-蛋白质相互作用的模型化合物。
    β-Lactose
  • HY-114440
    Belapectin Inhibitor
    Belapectin (GR-MD-02) 是一种半乳凝素-3 (Gal-3) 抑制剂。Belapectin 通过诱导 T 细胞凋亡 (Apoptosis) 来驱动肿瘤诱导的免疫抑制。Belapectin 通过 CD8+ T 细胞依赖机制,促进肿瘤消退并提高荷瘤小鼠生存率。Belapectin 结合 Gal-3 的 Ki 为 2.8 μM。
    Belapectin
  • HY-P1592A
    G3-C12 TFA 99.44%
    G3-C12 (TFA) 是 galectin-3 结合肽,Kd 值为 88 nM,具有抗肿瘤活性。
    G3-C12 TFA
  • HY-P1592
    G3-C12 99.44%
    G3-C12 是 galectin-3 结合肽,Kd 值为 88 nM,具有抗肿瘤活性。
    G3-C12
  • HY-146808
    Galectin-3 antagonist 1 Antagonist 99.77%
    Galectin-3 antagonist 1 (compound 15) 是一种有效的选择性 Galectin-3 (Gal-3) 拮抗剂,Kd 值为 5.3 μM。同时,Galectin-3 antagonist 1 结合多种 Galectin,Kd 值分别为 250 μM (GAl-4N)、18 μM (Gal-4C)、450 μM (Gal-8C)。
    Galectin-3 antagonist 1
  • HY-150235
    Galectin-8N-IN-1 Inhibitor 98.09%
    Galectin-8N-IN-1 (compound 19a) 是一种有效的选择性 galectin-8N 抑制剂,Kd 值为 1.8 μM。Galectin-8N-IN-1 是一种 galectin-8N 配体。Galectin-8N-IN-1可用于免疫系统的研究。
    Galectin-8N-IN-1
  • HY-144313
    Galectin-3-IN-2 Inhibitor
    Galectin-3-IN-2 (Compound 9) 是一种有效的多价半乳糖凝集素-3 (Gal-3; IC50=8.3 μM) 抑制剂。Galectin-3 参与许多与癌症相关的代谢过程。
    Galectin-3-IN-2
  • HY-139831
    Galectin-8-IN-1
    Galectin-8-IN-1 是 galectin-8N 的选择性配体,Kd为 48 μM,选择性是 galectin-3 的 15 倍,甚至比其他哺乳动物 galectins 的选择性更好。
    Galectin-8-IN-1
  • HY-146809
    Galectin-3 antagonist 2
    Galectin-3 是一种β半乳糖苷特异性碳水化合物识别蛋白(凝集素),有促进B细胞前体急性淋巴细胞白血病(BCP-ALL)细胞的迁移和承受药物治疗的能力。
    Galectin-3 antagonist 2
  • HY-157821
    Galectin-4-IN-3 Inhibitor
    Galectin-4-IN-3 (Compound 11) 是一种半乳糖凝集素 4C (Galectin 4C) 抑制剂,Kd 为 160 μM。
    Galectin-4-IN-3
  • HY-163407
    Galectin-3-IN-4 Inhibitor
    Galectin-3-IN-4 (compound 5) 是一种羧酰胺类似物。Galectin-3-IN-4 是一种有效的、选择性的、口服生物可利用的人和小鼠 Galectin-3 抑制剂,对 hGal-3mGal-3IC50 值分别为 21 和 167 nM。 Galectin-3-IN-4 对于 hGal-1 和 hGal-9 的 IC50 值分别为 1580 和 2750 nM[1]
    Galectin-3-IN-4
  • HY-155191
    Galectin-3/galectin-8-IN-1 Inhibitor
    Galectin-3/galectin-8-IN-1 (Compound 53) 是一种双重 Galectin-3galectin-8 C 末端结构域抑制剂,K d 值分别为 4.12 μM 和 6.04 μM。Galectin-3/galectin-8-IN-1 抑制 MRC-5 肺成纤维细胞迁移。Galectin-3/galectin-8-IN-1 可用于癌症和组织纤维化的研究。
    Galectin-3/galectin-8-IN-1
  • HY-155192
    Galectin-3/galectin-8-IN-2 Inhibitor
    Galectin-3/galectin-8-IN-2 (Compound 57) 是一种双重 Galectin-3galectin-8 C 末端结构域抑制剂,Kd 值分别为 12.8 μM 和 2.06 μM。Galectin-3/galectin-8-IN-2 抑制 MRC-5 肺成纤维细胞迁移。Galectin-3/galectin-8-IN-2 可用于癌症和组织纤维化的研究。
    Galectin-3/galectin-8-IN-2
目录号 产品名 / 同用名 应用 反应物种

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.