1. Signaling Pathways
  2. Immunology/Inflammation
  3. Galectin


Galectins are a family of proteins that possess β-galactoside-binding properties through their carbohydrate recognition domains (CRDs). Galectins can be secreted from cells by nonclassic pathways to interact with external glycoconjugates and have a variety of activities both extra- and intracellularly, with important implicated roles in immunity, inflammation, and cancer.

Galectins can be classified according to the CRD features. Galectin-1, -2, -5, -7, -10, -11, -13, and -14 are composed of a CRD and a short N-terminal sequence (prototype). Galectin-4, -6, -8, -9, and -12 have two nonidentical CRDs in tandem with a short linker sequence (tandem-repeat type). Galectin-3 has an exceptional structure, with a CRD and an extended N-terminal domainconsisting of gycine/proline-rich repeats and a short N-terminal end (chimera type). Galectin-1 (Gal1), a carbohydrate-binding protein is implicated in cancer cell proliferation, invasion and tumour angiogenesis. Galectin-3 (Gal3) is a β-galactoside binding lectin that is highly expressed in fibrotic tissue of diverse etiologies.

Galectins have emerged as key players in the tumor microenvironment. Galectins are expressed and released by different celltypes, including tumor, stromal, endothelial and immune cells. Galectins critically influence tumor progression by modulating tumor cell migration, invasiveness, angiogenesis and antitumor immune responses. Intracellularly, galectins modulate survival and proliferation and they interact with a variety of signaling pathways. Given these extracellular and intracellular functions and their regulated expression at sites of tumor growth and metastasis, galectins have stimulated great interest as relevant biomarkers and novel targets in cancer therapy.

Galectin 相关产品 (4):

Cat. No. Product Name Effect Purity
  • HY-19756
    OTX008 Inhibitor 99.36%
    OTX008 是一个半乳糖凝集素 1 (galectin-1) 的选择性抑制剂。
  • HY-P1592A
    G3-C12 TFA 99.44%
    G3-C12 (TFA) 是 galectin-3 结合肽,Kd 值为 88 nM,具有抗肿瘤活性。
  • HY-114409
    GB1107 Inhibitor
    GB1107 是一个有效的、选择性的、具有口服活性的 半乳糖凝集素 3 (Gal-3) 的抑制剂,其对人Gal-3的Kd 值为 37 nM。GB1107 可降低人和小鼠肺腺癌的生长并抑制转移。
  • HY-128852
    N-​Acetyl-​d-​galactosamine Inhibitor
    N-Acetyl-D-galactosamine (GalNAc) N-乙酰-D-半乳糖胺是衍生自半乳糖的末端必需氨基糖,并参与 A 血型抗原的形成。 N-Acetyl-D-galactosamine (GalNAc) N-乙酰-D-半乳糖胺与大豆凝集素 (SBA) 相互作用,从而降低 SBA 对细胞膜通透性和紧密连接蛋白表达的影响。 N-Acetyl-D-galactosamine (GalNAc) N-乙酰-D-半乳糖胺抑制凝集素的血凝活性。
  • HY-P1592
    G3-C12 是 galectin-3 结合肽,Kd 值为 88 nM,具有抗肿瘤活性。
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