1. Signaling Pathways
  2. GPCR/G Protein
  3. GPR171

GPR171 (G蛋白偶联受体171)

G Protein-Coupled Receptor 171

GPR171 is a G protein-coupled receptor (GPCR) with close homology to the P2Y receptors. GPR171 is expressed within the periaqueductal gray. BigLEN, a 16-amino acid neuropeptide derived from a neuroendocrine secretory pathway protein proSAAS, has been identified as the endogenous ligand for GPR171. GPR171 is reported to regulate mu opioid receptor signaling, antinociception, feeding and anxiety behaviors. On the other hand, GPR171 is a well-accepted T-cell signature gene in cancer database analysis, though its potential immune function is untested. Based on early published databases, GPR171 expression tends to be upregulated in tumor-infiltrating lymphocytes (TILs) and its expression in melanoma patients is significantly increased in response to immunotherapies. All these imply a possible role of GPR171 in T-cell immunity.

GPR171 相关产品 (5):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-116797
    MS15203 99.51%
    MS15203 是一种有效的选择性 GPR171 激动剂。MS15203 增加食物摄入量和体重。MS15203 增加神经元活动。MS15203 显着增加了编码 proSAAS、NPY、AgRP 的 mRNA 的丰度。
  • HY-112620
    MS21570 99.93%
    MS21570 是 GPR171 的选择性拮抗剂,其 IC50 值为 220 nM。
  • HY-P2210
    BigLEN(mouse) 99.98%
    BigLEN(mouse) 是一种有效和选择性的孤儿 G 蛋白偶联受体 171 (GPR171) 激动剂,Kd 值约为 0.5 nM。BigLEN(mouse) 可用于调节与食物摄入和新陈代谢相关的反应。
  • HY-P2155
    BigLEN(rat) 98.98%
    BigLEN(rat) 是一种有效的 GPR171 激动剂,其EC50 为 1.6 nM。
  • HY-P2155A
    BigLEN(rat) TFA
    BigLEN(rat)是一种有效的GPR171激动剂,其EC50 为1.6 nM。
    BigLEN(rat) TFA