1. Signaling Pathways
  2. Immunology/Inflammation
  3. VAP-1

VAP-1 

Vascular adhesion protein-1 (VAP-1); Semicarbazide-sensitive amine oxidase (SSAO); Amine oxidase copper-containing 3 (AOC3)

VAP-1 is a is a dual-function protein with adhesion properties and semicarbazide-sensitive monoamine oxidase (SSAO) activity. VAP-1 is involved in leukocyte-subtype-specific rolling under physiological shear. And VAP-1 catalyzes the oxidation of primary amines leading to the production of ammonium, formaldehyde, methylglyoxal, and hydrogen peroxide. Its catalytic activity can lead to cellular oxidative stress, which has been implicated in several pathologies (atherosclerosis, diabetes, and Alzheimer's disease).

VAP-1 相关产品 (5):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P99323
    Timolumab

    替莫鲁单抗

    Inhibitor 98.56%
    Timolumab (BTT1023 ) 是一种重组的、全人的单克隆,可特异性结合VAP-1。Timolumab (BTT1023 ) 可用于慢性炎症性疾病的研究。
    Timolumab
  • HY-P99526
    Vapaliximab

    伐利昔单抗

    Inhibitor
    Vapaliximab (2D10) 是一种抗人 VAP-1 的单克隆抗体。
    Vapaliximab
  • HY-157530
    VAP-1-IN-3 Inhibitor
    VAP-1-IN-3 (compound 136) 是一种有效的胺氧化酶血管粘附蛋白-1 (VAP-1) 抑制剂,抑制从牛血浆中分离出的 VAP-1IC50 值为 0.13 μM。VAP-1-IN-3 可用于炎症研究。
    VAP-1-IN-3
  • HY-117833
    PXS-4681A Inhibitor
    PXS-4681A 是一种有效、选择性、不可逆且具有口服活性的氨基脲敏感胺氧化酶 (SSAO; VAP-1) 抑制剂,Ki 为 37 nM。PXS-4681A 对相关的胺氧化酶、离子通道和七跨膜结构域受体显示出高度选择性。PXS-4681A 具有抗炎作用。
    PXS-4681A
  • HY-142444
    SSAO/VAP-1 inhibitor 1 Inhibitor
    SSAO/VAP-1 inhibitor 1 是一种有效的 SSAO/VAP-1抑制剂。SSAO/VAP-1 促进葡萄糖转运 4 (GLUT 4) 从脂肪细胞转移到细胞膜,从而调节葡萄糖转运。在内皮细胞中,SSAO/VAP-1 可以介导白细胞和内皮细胞的粘附和渗出,并参与炎症反应。SSAO/VAP-1 inhibitor 1 具有研究炎症和/或炎症相关疾病或糖尿病和/或糖尿病相关疾病的潜力 (信息提取摘自专利 WO2021102774A1,化合物 E3)。
    SSAO/VAP-1 inhibitor 1