GluR-3 抗体 (YA4880)

GluR-3 Antibody (YA4880) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to GluR-3.

GluR-3 是一种离子型谷氨酸受体，作为配体门控阳离子通道发挥作用，由 L-谷氨酸和谷氨酸能激动剂如 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)、quisqualic acid 和 kainic acid 激活 (By similarity)。L-谷氨酸在中枢神经系统的许多突触中作为兴奋性神经递质，并通过诱导长时程增强在快速兴奋性突触传递中发挥重要作用 (By similarity)。兴奋性神经递质 L-谷氨酸的结合诱导构象变化，导致阳离子通道开放，从而在钙离子进入时将化学信号转换为电脉冲 (PubMed:17989220)。随后受体迅速脱敏并进入短暂的失活状态，其特征是存在结合的激动剂 (PubMed:17989220)。在 CACNG8 存在的情况下，表现出再敏化特征，即在持续应用谷氨酸时电流通量延迟积累 (PubMed:21172611)。

P42263

Predicted band size: 101 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; IHC: 1:200-1:1000; ELISA: 1:10000; ICC/IF: 1:50-200

WB, IHC-P, ICC/IF, ELISA

液体

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of human GluR-3 expressed in E. Coli.