NAA10 抗体 (YA4003)

NAA10 Antibody (YA4003) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NAA10.

NAA10 是 N-terminal acetyltransferase 复合物的催化亚基，具有 alpha (N-terminal) acetyltransferase 活性，能够乙酰化缺乏起始甲硫氨酸的氨基末端，可能在血管、造血和神经元生长与发育中起重要作用。在没有 NAA15 的情况下，NAA10 对 HIF1A 表现出 epsilon (internal) acetyltransferase 活性，促进其降解。此外，NAA10 通过乙酰化 MYLK 抑制其激酶活性，从而抑制肿瘤细胞迁移；通过乙酰化并稳定 TSC2 抑制 mTOR 活性，阻碍癌症发展；乙酰化 HSPA1A 和 HSPA1B 的 'Lys-77' 增强其分子伴侣活性，促进与 co-chaperone HOPX 的结合；乙酰化 HIST1H4A；并在有丝分裂中作为姐妹染色单体凝聚的负调控因子。

P41227

Predicted band size: 26 kDa; Observed band size: 26 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal Antibody

Mouse

Human, Mouse, Monkey

WB: 1:500-1:2000; IF: 1:200-1:1000; FC: 1:200-1:400; ELISA: 1:10000

WB, ICC/IF, FC, ELISA

液体

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human NAA10 (AA: 111-235) expressed in E. Coli.