PARP3 - poly(ADP-ribose) polymerase family member 3 Gene

中文名称：聚 (ADP-核糖) 聚合酶家族成员 3

种属: Homo sapiens

同用名: IRT1; ARTD3; ADPRT3; ADPRTL2; ADPRTL3; PADPRT-3

基因 ID: 10039 | 基因类型: protein coding

关于 PARP3

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:51,942,363-51,948,867 (from NCBI)

This gene has 9 transcripts (splice variants), 198 orthologues and 2 paralogues. Ubiquitous expression in duodenum (RPKM 12.4), small intestine (RPKM 11.6) and 24 other tissues.

功能概要

该基因编码的蛋白质属于 PARP 家族。这些酶通过聚-ADP-核糖基化修饰核蛋白，这是 DNA 修复、细胞凋亡调节和基因组稳定性维持所必需的。该基因编码聚 (ADP-核糖基) 转移酶 3，它在整个细胞周期中优先定位于子中心粒。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene belongs to the PARP family. These Enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of Apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PARP3 基因产物(6)

mRNA	Protein	Name
NM_001370239.1	NP_001357168.1	protein mono-ADP-ribosyltransferase PARP3 isoform a
NM_001370240.1	NP_001357169.1	protein mono-ADP-ribosyltransferase PARP3 isoform a
NM_005485.6	NP_005476.4	protein mono-ADP-ribosyltransferase PARP3 isoform a
NM_001003931.4	NP_001003931.4	protein mono-ADP-ribosyltransferase PARP3 isoform a
NM_001003935.2
XM_047447087.1	XP_047303043.1	protein mono-ADP-ribosyltransferase PARP3 isoform X1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables NAD DNA ADP-ribosyltransferase activity	IDA IDA: 通过直接分析推断	29361132	GOA
enables NAD+-protein ADP-ribosyltransferase activity	IDA IDA: 通过直接分析推断	20064938	GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA IDA: 通过直接分析推断	21211721	GOA
enables NAD+-protein-aspartate ADP-ribosyltransferase activity	IDA IDA: 通过直接分析推断	20064938	GOA
enables NAD+-protein-glutamate ADP-ribosyltransferase activity	IDA IDA: 通过直接分析推断	20064938	GOA
enables NAD+-protein-lysine ADP-ribosyltransferase activity	IDA IDA: 通过直接分析推断	25043379	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	20064938	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA ADP-ribosylation	IDA IDA: 通过直接分析推断	29361132	GOA
acts upstream of or within double-strand break repair	IDA IDA: 通过直接分析推断	21270334	GOA
acts upstream of or within double-strand break repair	IMP IMP: 通过突变表型推断	21211721	GOA
acts upstream of or within positive regulation of DNA ligation	IGI IGI: 通过遗传相互作用推断	21211721	GOA
involved in positive regulation of double-strand break repair via nonhomologous end joining	IDA IDA: 通过直接分析推断	24598253	GOA
involved in protein auto-ADP-ribosylation	IDA IDA: 通过直接分析推断	25043379	GOA
acts upstream of or within protein localization to site of double-strand break	IMP IMP: 通过突变表型推断	21211721	GOA
NOT involved in protein poly-ADP-ribosylation	IDA IDA: 通过直接分析推断	25043379	GOA
acts upstream of or within regulation of mitotic spindle organization	IMP IMP: 通过突变表型推断	21270334	GOA
acts upstream of or within telomere maintenance	IMP IMP: 通过突变表型推断	21270334	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in site of double-strand break	IDA IDA: 通过直接分析推断	21270334	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PARP3 蛋白结构

WGR

PARP_reg

PARP

0
100
200
300
400
500
533 a.a.

蛋白主名

其他名称

protein mono-ADP-ribosyltransferase PARP3

ADP-ribosyltransferase (NAD+	poly (ADP-ribose) polymerase)-like 2
ADP-ribosyltransferase (NAD+	poly (ADP-ribose) polymerase)-like 3
ADP-ribosyltransferase diphtheria toxin-like 3	ADPRT-3
DNA ADP-ribosyltransferase PARP3	NAD(+) ADP-ribosyltransferase 3
NAD+ ADP-ribosyltransferase 3	poly [ADP-ribose] polymerase 3
poly(ADP-ribose) synthetase-3	poly[ADP-ribose] synthase 3
poly[ADP-ribose] synthetase 3

关联疾病

疾病名称

别名

Alcohol-Related Birth Defects

Arbd	Alcohol-Related Birth Defect
Alcohol Related Birth Defect	Fetal Alcohol Syndrome

Osebold-Remondini Syndrome

Brachydactyly Type A6	Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities
Bda6	Brachydactyly, Type A6

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-10619	Niraparib	Inhibitor	99.96%	是
HY-10617A	Rucaparib	Inhibitor	99.97%	否
HY-10617	Rucaparib phosphate	Inhibitor	99.76%	是
HY-10619A	Niraparib hydrochloride	Inhibitor	99.41%	是
HY-10619B	Niraparib tosylate	Inhibitor	99.99%	是
HY-102003	Rucaparib (monocamsylate)	Inhibitor	99.91%	是
HY-10619E	Niraparib tosylate hydrate	Inhibitor	99.97%	是
HY-10617C	Rucaparib tartrate	Inhibitor	/	否
HY-102003A	Rucaparib camsylate	Inhibitor	/	否
HY-10617D	Rucaparib acetate	Inhibitor	/	否
HY-10617B	Rucaparib hydrochloride	Inhibitor	/	否

目录号	产品名	作用方式	纯度	Phase
HY-13536	AZD-2461	Inhibitor	99.79%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-148566	OUL232	Inhibitor	99.86%	否
HY-150207	RBN-3143	Inhibitor	99.29%	否
HY-100225	ME0328	Inhibitor	99.64%	否
HY-148754	PARP10-IN-3	Inhibitor	98.72%	否
HY-148753	PARP10-IN-2	Inhibitor	98.02%	否
HY-155993	YCH1899	Inhibitor	99.39%	否
HY-W294889	OUL245	Inhibitor	/	否
HY-100847	AZ0108	Inhibitor	/	否
HY-178032	PARP1-IN-44	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	PARP3	VGNC	VGNC:80647
Macaca mulatta	PARP3	VGNC	VGNC:84055
Mus musculus	PARP3	MGD	MGI:1891258
Rattus norvegicus	PARP3	RGD	RGD:1305189
Canis familiaris	PARP3	VGNC	VGNC:81897
Others	PARP3	NCBI

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