2. Gene
  3. PARP3 - poly(ADP-ribose) polymerase family member 3 Gene

PARP3 - poly(ADP-ribose) polymerase family member 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：聚 (ADP-核糖) 聚合酶家族成员 3

种属: Homo sapiens

同用名: IRT1; ARTD3; ADPRT3; ADPRTL2; ADPRTL3; PADPRT-3

基因 ID: 10039 | 基因类型: protein coding

关于 PARP3

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:51,942,363-51,948,867 (from NCBI)

This gene has 9 transcripts (splice variants), 198 orthologues and 2 paralogues. Ubiquitous expression in duodenum (RPKM 12.4), small intestine (RPKM 11.6) and 24 other tissues.

功能概要

该基因编码的蛋白质属于 PARP 家族。这些酶通过聚-ADP-核糖基化修饰核蛋白，这是 DNA 修复、细胞凋亡调节和基因组稳定性维持所必需的。该基因编码聚 (ADP-核糖基) 转移酶 3，它在整个细胞周期中优先定位于子中心粒。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of Apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PARP3 基因产物(6)

mRNA Protein Name
NM_001370239.1 NP_001357168.1 protein mono-ADP-ribosyltransferase PARP3 isoform a
NM_001370240.1 NP_001357169.1 protein mono-ADP-ribosyltransferase PARP3 isoform a
NM_005485.6 NP_005476.4 protein mono-ADP-ribosyltransferase PARP3 isoform a
NM_001003931.4 NP_001003931.4 protein mono-ADP-ribosyltransferase PARP3 isoform a
NM_001003935.2
XM_047447087.1 XP_047303043.1 protein mono-ADP-ribosyltransferase PARP3 isoform X1

PARP3 蛋白结构

WGR

WGR: WGR domain (64 - 143)

PARP_reg

PARP_reg: Poly(ADP-ribose) polymerase, regulatory domain (183 - 320)

PARP

PARP: Poly(ADP-ribose) polymerase catalytic domain (322 - 532)

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  • 533 a.a.
蛋白主名 其他名称

protein mono-ADP-ribosyltransferase PARP3

ADP-ribosyltransferase (NAD+

poly (ADP-ribose) polymerase)-like 2

ADP-ribosyltransferase (NAD+

poly (ADP-ribose) polymerase)-like 3

ADP-ribosyltransferase diphtheria toxin-like 3

ADPRT-3

DNA ADP-ribosyltransferase PARP3

NAD(+) ADP-ribosyltransferase 3

NAD+ ADP-ribosyltransferase 3

poly [ADP-ribose] polymerase 3

poly(ADP-ribose) synthetase-3

poly[ADP-ribose] synthase 3

poly[ADP-ribose] synthetase 3

重组 PARP3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75955 PARP3 Protein, Human (sf9, His-GST) Q9Y6F1 (M1-L533) ≥95%

关联疾病

疾病名称 别名
Alcohol-Related Birth Defects

Arbd

Alcohol-Related Birth Defect

Alcohol Related Birth Defect

Fetal Alcohol Syndrome
Osebold-Remondini Syndrome

Brachydactyly Type A6

Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities

Bda6

Brachydactyly, Type A6
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (11)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10619 Niraparib Inhibitor 99.96% 是
HY-10617A Rucaparib Inhibitor 99.84% 是
HY-10619B Niraparib tosylate Inhibitor 99.99% 是
HY-10619A Niraparib hydrochloride Inhibitor 99.76% 是
HY-102003 Rucaparib monocamsylate Inhibitor 99.82% 是
HY-10617 Rucaparib phosphate Inhibitor 99.76% 是
HY-10619E Niraparib tosylate hydrate Inhibitor 99.97% 是
HY-10617C Rucaparib tartrate Inhibitor / 否
HY-102003A Rucaparib camsylate Inhibitor / 否
HY-10617D Rucaparib acetate Inhibitor / 否
HY-10617B Rucaparib hydrochloride Inhibitor / 否
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-13536 AZD-2461 Inhibitor 99.88% Phase 1
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-150207 RBN-3143 Inhibitor 99.24% 否
HY-100225 ME0328 Inhibitor 99.87% 否
HY-148566 OUL232 Inhibitor / 否
HY-148753 PARP10-IN-2 Inhibitor 98.02% 否
HY-148754 PARP10-IN-3 Inhibitor 98.89% 否
HY-W294889 OUL245 Inhibitor / 否
HY-155993 YCH1899 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PARP3 VGNC VGNC:80647
Macaca mulatta PARP3 VGNC VGNC:84055
Mus musculus PARP3 MGD MGI:1891258
Rattus norvegicus PARP3 RGD RGD:1305189
Canis familiaris PARP3 VGNC VGNC:81897
Others PARP3 NCBI