MICA - MHC class I polypeptide-related sequence A Gene

中文名称：MHC I 类多肽相关序列 A

种属: Homo sapiens

同用名: MIC-A; PERB11.1

关于 MICA

功能概要

该基因编码高度多态性的主要组织相容性复合物 I 类链相关蛋白 A。该蛋白产物在细胞表面表达，尽管与典型的 I 类分子不同，它似乎不与 β-2-微球蛋白相关联。它是 NKG2-D II 型整合膜蛋白受体的配体。该蛋白作为应激诱导抗原发挥作用，可被肠上皮γδ T 细胞广泛识别。该基因的变异与银屑病 1 和银屑病关节炎的易感性有关，并且 MICA 相关抗体和配体的脱落参与了从意义不明的单克隆丙种球蛋白病到多发性骨髓瘤的进展。该基因的可变剪接导致多个转录变体。[RefSeq 提供，2014 年 1 月]

This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]