2. Gene
  3. TOB1 - transducer of ERBB2, 1 Gene

TOB1 - transducer of ERBB2, 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 直系同源

中文名称：ERBB2, 1 换能器

种属: Homo sapiens

同用名: TOB; TROB; APRO5; APRO6; PIG49; TROB1

基因 ID: 10140 | 基因类型: protein coding

关于 TOB1

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,862,223-50,867,978 (from NCBI)

This gene has 3 transcripts (splice variants), 264 orthologues and 1 paralogue. Ubiquitous expression in adrenal (RPKM 113.0), thyroid (RPKM 46.6) and 25 other tissues.

功能概要

该基因编码 erbB-2/B 细胞易位基因蛋白家族的一个成员。该家族的成员是具有调节细胞生长潜力的抗增殖因子。所编码的蛋白质可能起到肿瘤抑制因子的作用。交替剪接导致多个转录本变体。[RefSeq 提供，2011 年 8 月]

This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

TOB1 基因产物(3)

mRNA Protein Name
NM_001243877.2 NP_001230806.1 protein Tob1 isoform 1
NM_001243885.2 NP_001230814.1 protein Tob1 isoform 2
NM_005749.4 NP_005740.1 protein Tob1 isoform 1

TOB1 蛋白结构

BTG

BTG: BTG family (1 - 114)

  • 0
  • 100
  • 200
  • 300
  • 345 a.a.
蛋白主名 其他名称

protein Tob1

proliferation-inducing gene 49

关联疾病

疾病名称 别名
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TOB1 VGNC VGNC:78613
Mus musculus TOB1 MGD MGI:1349721
Felis catus TOB1 VGNC VGNC:82316
Bos taurus TOB1 VGNC VGNC:36212
Canis familiaris TOB1 VGNC VGNC:49663
Rattus norvegicus TOB1 RGD RGD:621126