2. Gene
  3. Nlrp6 - NLR family, pyrin domain containing 6 Gene

Nlrp6 - NLR family, pyrin domain containing 6 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Avr; Navr; Nalp6; Pypaf5; Non-AVR; Navr/Avr

基因 ID: 101613 | 基因类型: protein coding

关于 Nlrp6

功能概要

The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. [provided by RefSeq, Feb 2013]

Nlrp6 基因产物(1)

mRNA Protein Name
NM_133946.2 NP_598707.2 NACHT, LRR and PYD domains-containing protein 6
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables double-stranded RNA binding IDA
IDA: 通过直接分析推断
34678144 MGI
enables lipoteichoic acid binding IDA
IDA: 通过直接分析推断
30392956 MGI
enables molecular condensate scaffold activity IDA
IDA: 通过直接分析推断
34678144 MGI
enables pattern recognition receptor activity IDA
IDA: 通过直接分析推断
34678144 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
26494172 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in NLRP6 inflammasome complex assembly IDA
IDA: 通过直接分析推断
32424362 MGI
acts upstream of or within activation of cysteine-type endopeptidase activity IMP
IMP: 通过突变表型推断
30248149 MGI
acts upstream of or within acute inflammatory response IMP
IMP: 通过突变表型推断
30248149 MGI
acts upstream of or within acute inflammatory response to antigenic stimulus IMP
IMP: 通过突变表型推断
30248149 MGI
involved in antiviral innate immune response IDA
IDA: 通过直接分析推断
34678144 MGI
involved in antiviral innate immune response IMP
IMP: 通过突变表型推断
26494172 MGI
involved in defense response to Gram-positive bacterium IDA
IDA: 通过直接分析推断
30392956 MGI
involved in defense response to virus IMP
IMP: 通过突变表型推断
26494172 MGI
NOT involved in host-mediated regulation of intestinal microbiota composition IMP
IMP: 通过突变表型推断
28801232 MGI
involved in host-mediated regulation of intestinal microbiota composition IMP
IMP: 通过突变表型推断
26638072 MGI
acts upstream of or within interleukin-1 beta production IMP
IMP: 通过突变表型推断
30248149 MGI
acts upstream of or within interleukin-18 production IMP
IMP: 通过突变表型推断
30248149 MGI
acts upstream of or within necroptotic process IMP
IMP: 通过突变表型推断
30248149 MGI
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
22763455 MGI
acts upstream of or within negative regulation of MAPK cascade IMP
IMP: 通过突变表型推断
22763455 MGI
acts upstream of or within negative regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
22763455 MGI
involved in negative regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
22763455 MGI
acts upstream of or within negative regulation of immune response IMP
IMP: 通过突变表型推断
22763455 MGI
involved in negative regulation of inflammatory response to antigenic stimulus IMP
IMP: 通过突变表型推断
22763455 MGI
acts upstream of or within negative regulation of toll-like receptor signaling pathway IMP
IMP: 通过突变表型推断
22763455 MGI
acts upstream of or within negative regulation of type II interferon production IMP
IMP: 通过突变表型推断
30248149 MGI
acts upstream of or within neutrophil-mediated killing of gram-positive bacterium IMP
IMP: 通过突变表型推断
30248149 MGI
involved in positive regulation of inflammatory response IDA
IDA: 通过直接分析推断
26494172 MGI
involved in positive regulation of interleukin-18-mediated signaling pathway IDA
IDA: 通过直接分析推断
30392956 MGI
involved in positive regulation of interleukin-18-mediated signaling pathway IMP
IMP: 通过突变表型推断
26638072 MGI
involved in protein homooligomerization IDA
IDA: 通过直接分析推断
34678144 MGI
involved in pyroptotic inflammatory response IDA
IDA: 通过直接分析推断
34678144 MGI
acts upstream of or within pyroptotic inflammatory response IMP
IMP: 通过突变表型推断
30248149 MGI
acts upstream of or within regulation of autophagy IMP
IMP: 通过突变表型推断
24581500 MGI
acts upstream of or within regulation of inflammatory response IMP
IMP: 通过突变表型推断
23696660 MGI
involved in regulation of inflammatory response IMP
IMP: 通过突变表型推断
21543645 MGI
acts upstream of or within regulation of mucus secretion IMP
IMP: 通过突变表型推断
24581500 MGI
acts upstream of or within response to bacterium IMP
IMP: 通过突变表型推断
23075849 MGI
acts upstream of or within wound healing IMP
IMP: 通过突变表型推断
21593405 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of NLRP6 inflammasome complex IDA
IDA: 通过直接分析推断
32424362 MGI
part of canonical inflammasome complex IDA
IDA: 通过直接分析推断
30248149 MGI
is active in non-membrane-bounded organelle IDA
IDA: 通过直接分析推断
34678144 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

NACHT, LRR and PYD domains-containing protein 6

NACHT, leucine rich repeat and PYD containing 6

NACHT/LRR/pyrin domain-containing protein 6

PYRIN-containing APAF1-like protein 5

angiotensin II/vasopressin receptor

non-angiotensin-vasopressin receptor

Nlrp6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Nlrp6 Q91WS2 Dhx15 Mus musculus O35286
Anti Bait CoIP
26494172
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09362 NLRP6 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17708 Nlrp6 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24173 Nlrp6 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nlrp6 NCBI NCBI:171389
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