2. Gene
  3. Ano1 - anoctamin 1, calcium activated chloride channel Gene

Ano1 - anoctamin 1, calcium activated chloride channel Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Tmem16a

基因 ID: 101772 | 基因类型: protein coding

关于 Ano1

功能概要

Enables intracellular calcium activated Chloride Channel activity; protein homodimerization activity; and voltage-gated Chloride Channel activity. Involved in several processes, including chloride transmembrane transport; detection of temperature stimulus involved in sensory perception of pain; and positive regulation of Insulin secretion involved in cellular response to glucose stimulus. Acts upstream of or within regulation of membrane potential. Located in apical plasma membrane and external side of plasma membrane. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ANO1 (anoctamin 1). [provided by Alliance of Genome Resources, Apr 2022]

Ano1 基因产物(2)

mRNA Protein Name
NM_001242349.2 NP_001229278.2 anoctamin-1 isoform 2
NM_178642.6 NP_848757.5 anoctamin-1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chloride channel activity IDA
IDA: 通过直接分析推断
25779870 MGI
enables chloride channel activity IMP
IMP: 通过突变表型推断
24885604 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
23576756 MGI
enables intracellularly calcium-gated chloride channel activity IDA
IDA: 通过直接分析推断
18724360 MGI
NOT enables phospholipid scramblase activity IDA
IDA: 通过直接分析推断
23532839 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
23576756 MGI
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
28561733 MGI
enables voltage-gated chloride channel activity IDA
IDA: 通过直接分析推断
22634729 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to heat IDA
IDA: 通过直接分析推断
22634729 MGI
involved in chloride transmembrane transport IDA
IDA: 通过直接分析推断
22634729 MGI
involved in chloride transmembrane transport IMP
IMP: 通过突变表型推断
24885604 MGI
acts upstream of or within chloride transport IDA
IDA: 通过直接分析推断
20056604 MGI
involved in chloride transport IDA
IDA: 通过直接分析推断
18724360 MGI
involved in chloride transport IMP
IMP: 通过突变表型推断
28963502 MGI
NOT involved in detection of mechanical stimulus involved in sensory perception of pain IMP
IMP: 通过突变表型推断
22634729 MGI
involved in detection of temperature stimulus involved in sensory perception of pain IGI
IGI: 通过遗传相互作用推断
22634729 MGI
involved in detection of temperature stimulus involved in sensory perception of pain IMP
IMP: 通过突变表型推断
22634729 MGI
acts upstream of or within establishment of localization in cell IDA
IDA: 通过直接分析推断
23532839 MGI
involved in glial cell projection elongation IMP
IMP: 通过突变表型推断
31147466 MGI
involved in mucus secretion IMP
IMP: 通过突变表型推断
30586313 MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
22634729 MGI
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: 通过突变表型推断
24885604 MGI
acts upstream of or within regulation of membrane potential IGI
IGI: 通过遗传相互作用推断
23133519 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: 通过突变表型推断
23133519 MGI
involved in trachea development IMP
IMP: 通过突变表型推断
18585372 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
21516098 MGI
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
23576756 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
23840801 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
18585372 MGI
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
23840801 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

anoctamin-1

transmembrane protein 16A

Ano1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Ano1 Q8BHY3 Ano1 Mus musculus Q8BHY3
3D-EM-Single
29236691
种属内
Ano1 Q8BHY3 Ano1 Mus musculus Q8BHY3
3D-EM
29236684
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (15)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100612 T16Ainh-A01 Inhibitor 99.0% 否
HY-119981 Ani9 Inhibitor 99.12% 否
HY-146320 ANO1-IN-1 Inhibitor 99.57% 否
HY-146334 DFBTA Inhibitor 99.25% 否
HY-105917 Emidurdar Inhibitor 99.41% 是
HY-118170 T16A(inh)-C01 Inhibitor 90% 否
HY-N5101 Kobusin 99.93% 否
HY-146321 ANO1-IN-2 Inhibitor / 否
HY-147874 ANO1-IN-3 / 否
HY-153508 ANO1-IN-4 Inhibitor / 否
HY-175669 ANO1-IN-5 Inhibitor / 否
HY-RS00740 ANO1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS00750 ANOS1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17326 Ano1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23781 Ano1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990337 Anti-ANO1/TMEM16A Antibody Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ano1 NCBI NCBI:55107
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z