1. Gene
  2. RBM5 - RNA binding motif protein 5 Gene

RBM5 - RNA binding motif protein 5 Gene

中文名称:RNA 结合基序蛋白 5

种属: Homo sapiens

同用名: G15; H37; RMB5; LUCA15; LUCA-15

基因 ID: 10181 | 基因类型: protein coding

关于 RBM5

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:50,088,919-50,119,021 (from NCBI)

This gene has 26 transcripts (splice variants), 262 orthologues and 2 paralogues. Ubiquitous expression in skin (RPKM 32.9), endometrium (RPKM 30.9) and 25 other tissues.

功能概要

该基因是一种候选肿瘤抑制基因,它编码一种核 RNA 结合蛋白,该蛋白是剪接体 A 复合物的一个组成部分。编码的蛋白质通过多个靶基因 (包括肿瘤抑制蛋白 p53) 的 pre-mRNA 剪接,在诱导细胞周期停滞和细胞凋亡中发挥作用。该基因位于肿瘤抑制区域 3p21.3 内,可能在抑制包括肺癌在内的多种恶性肿瘤的肿瘤转化和进展中发挥作用。[RefSeq 提供,2011 年 10 月]

This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and Apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung Cancer. [provided by RefSeq, Oct 2011]

RBM5 基因产物(1)

mRNA Protein Name
NM_005778.4 NP_005769.1 RNA-binding protein 5

RBM5 蛋白结构

(100 - 171)

zf-RanBP

zf-RanBP: Zn-finger in Ran binding protein and others (181 - 209)

(233 - 308)

G-patch

G-patch: G-patch domain (743 - 787)

  • 0
  • 200
  • 400
  • 600
  • 815 a.a.
蛋白主名 其他名称

RNA-binding protein 5

putative tumor suppressor LUCA15

关联疾病

疾病名称 别名
Primary Ovarian Insufficiency 6
Tarp Syndrome

TARPS

Pierre Robin Syndrome With Congenital Heart Malformation And Clubfoot

Pierre Robin Sequence-Congenital Heart Defect-Talipes Syndrome

Pierre Robin Syndrome-Congenital Heart Defect-Talipes Syndrome

Talipes Equinovarus-Atrial Septal Defect-Robin Sequence-Persistence Of The Left Superior Vena Cava Syndrome

Talipes Equinovarus, Atrial Septal Defect, Robin Sequence, And Persistence Of Left Superior Vena Cava

Pierre Robin Sequence - Congenital Heart Defect - Talipes

Pierre Robin Syndrome - Congenital Heart Defect - Talipes

Talipes Equinovarus - Atrial Septal Defect - Robin Sequence - Persistence Of The Left Superior Vena Cava

Talipes Equinovarus Atrial Septal Defect Robin Sequence And Persistence Of Left Superior Vena Cava

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Medulloblastoma Wnt Activated
Medulloblastoma Shh Activated
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus RBM5 MGD MGI:1933204
Canis familiaris RBM5 VGNC VGNC:45424
Felis catus RBM5 VGNC VGNC:69265
Bos taurus RBM5 VGNC VGNC:33806
Macaca mulatta RBM5 VGNC VGNC:76682
Rattus norvegicus RBM5 RGD RGD:1305059