2. Gene
  3. TNK2 - tyrosine kinase non receptor 2 Gene

TNK2 - tyrosine kinase non receptor 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：酪氨酸激酶非受体 2

种属: Homo sapiens

同用名: ACK; ACK1; ACK-1; p21cdc42Hs

基因 ID: 10188 | 基因类型: protein coding

关于 TNK2

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:195,863,364-195,908,551 (from NCBI)

This gene has 31 transcripts (splice variants), 153 orthologues, 32 paralogues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 21.9), bone marrow (RPKM 14.7) and 24 other tissues.

功能概要

该基因编码一种酪氨酸激酶，该激酶以其 GTP 结合形式结合 Cdc42Hs，并抑制 Cdc42Hs 的内在和 GTP 酶激活蛋白 (GAP) 刺激的 GTP 酶活性。这种结合是由 47 个氨基酸的独特序列 C 端到 SH3 结构域介导的。该蛋白质可能参与维持 Cdc42Hs 的 GTP 结合活性形式的调节机制，并且直接与酪氨酸磷酸化信号转导途径相关。已从该基因中鉴定出几种选择性剪接的转录物变体，但仅确定了两种转录物变体的全长性质。[RefSeq 提供，2008 年 7 月]

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 Amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]

TNK2 基因产物(24)

mRNA Protein Name
NM_001010938.2 NP_001010938.2 activated CDC42 kinase 1 isoform 2
NM_001308046.2 NP_001294975.1 activated CDC42 kinase 1 isoform 3
NM_001382271.1 NP_001369200.1 activated CDC42 kinase 1 isoform 4
NM_001382272.1 NP_001369201.1 activated CDC42 kinase 1 isoform 5
NM_001382273.1 NP_001369202.1 activated CDC42 kinase 1 isoform 6
NM_001382274.1 NP_001369203.1 activated CDC42 kinase 1 isoform 6
NM_001382275.1 NP_001369204.1 activated CDC42 kinase 1 isoform 7
NM_001386164.1 NP_001373093.1 activated CDC42 kinase 1 isoform 8
NM_001387707.1 NP_001374636.1 activated CDC42 kinase 1 isoform 9
NM_001387708.1 NP_001374637.1 activated CDC42 kinase 1 isoform 10
NM_001387709.1 NP_001374638.1 activated CDC42 kinase 1 isoform 8
NM_001387710.1 NP_001374639.1 activated CDC42 kinase 1 isoform 8
NM_001387711.1 NP_001374640.1 activated CDC42 kinase 1 isoform 8
NM_001387712.1 NP_001374641.1 activated CDC42 kinase 1 isoform 8
NM_001387713.1 NP_001374642.1 activated CDC42 kinase 1 isoform 1
NM_001387714.1 NP_001374643.1 activated CDC42 kinase 1 isoform 1
NM_001387715.1 NP_001374644.1 activated CDC42 kinase 1 isoform 11
NM_001387716.1 NP_001374645.1 activated CDC42 kinase 1 isoform 12
NM_001387717.1 NP_001374646.1 activated CDC42 kinase 1 isoform 12
NM_001387718.1 NP_001374647.1 activated CDC42 kinase 1 isoform 12
NM_001387719.1 NP_001374648.1 activated CDC42 kinase 1 isoform 13
NM_001387720.1 NP_001374649.1 activated CDC42 kinase 1 isoform 13
NM_001387721.1 NP_001374650.1 activated CDC42 kinase 1 isoform 13
NM_005781.5 NP_005772.3 activated CDC42 kinase 1 isoform 1

TNK2 蛋白结构

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (126 - 384)

SH3_9

SH3_9: Variant SH3 domain (395 - 444)

GTPase_binding

GTPase_binding: GTPase binding (447 - 514)

Inhibitor_Mig-6

Inhibitor_Mig-6: EGFR receptor inhibitor Mig-6 (774 - 840)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1038 a.a.
蛋白主名 其他名称

activated CDC42 kinase 1

activated Cdc42-associated kinase 1

重组 TNK2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75542 ACK1 Protein, Human (sf9, GST) Q07912-1 (G110-W476) ≥95%

关联疾病

疾病名称 别名
Infantile-Onset Mesial Temporal Lobe Epilepsy With Severe Cognitive Regression
Ductal Carcinoma In Situ

Noninfiltrating Intraductal Carcinoma
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
Spinocerebellar Ataxia, Autosomal Recessive 15

Autosomal Recessive Spinocerebellar Ataxia 15

SCAR15

Salih Ataxia

Autosomal Recessive Cerebellar Ataxia-Epilepsy-Intellectual Disability Syndrome Due To Rubcn Deficiency

Autosomal Recessive Spinocerebellar Ataxia Type 15

Spinocerebellar Ataxia, Autosomal Recessive, 15

Ataxia, Spinocerebellar, Autosomal Recessive, Type 15
Gastric Cardia Carcinoma

Carcinoma Of Cardia Of Stomach
Atypical Chronic Myeloid Leukemia, Bcr-Abl1 Negative

Atypical Chronic Myeloid Leukemia

Atypical Chronic Myeloid Leukaemia

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Acml

Atypical Chronic Myeloid Leukaemia Bcr-Abl1 Negative

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Atypical Cml

Subacute Myeloid Leukemia

Subacute Myelogenous Leukaemia

Subacute Myeloid Leukaemia

Subacute Myelosis

Atypical Chronic Myeloid Leukaemia, Bcr-Abl-Negative Without Mention Of Remission

Subacute Monocytic Leukaemia Without Mention Of Remission

Subacute Monocytic Leukaemia
Immunodeficiency 46

Tfrc-Related Combined Immunodeficiency

IMD46

Cid Due To Tfrc Deficiency

Combined Immunodeficiency Due To Tfrc Deficiency
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-12418 Stenoparib Inhibitor ≥98.0% Phase 2
Pre-clinical Phase
生物活性分子 (28)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15147 XAV-939 Inhibitor 99.91% 否
HY-12438 G007-LK Inhibitor 99.42% 否
HY-13990 NVP-TNKS656 99.66% 否
HY-12975 AZ6102 Inhibitor 99.65% 否
HY-13968 JW 55 Inhibitor 98.95% 否
HY-16910 WIKI4 Inhibitor 99.93% 否
HY-19351 MN-64 Inhibitor 99.73% 否
HY-148063 DB0614 98.80% 否
HY-U00422 K-756 Inhibitor 99.76% 否
HY-101243 XMD16-5 Inhibitor 98.59% 否
HY-123851 MSC2504877 Inhibitor 98.50% 否
HY-15811 XMD8-87 Inhibitor 98.63% 否
HY-121719 TIQ-A Inhibitor 99.65% 否
HY-143338 ART-IN-1 Inhibitor 98.91% 否
HY-148061 DB1113 99.28% 否
HY-147886 PARP1-IN-11 Inhibitor 98.58% 否
HY-126248 Tankyrase-IN-2 Inhibitor 99.60% 否
HY-145111 TNK2-IN-1 Inhibitor / 否
HY-146336 PARP1/2/TNKS1/2-IN-1 / 否
HY-148065 FMF-06-098-1 / 否
HY-153259 TNKS1/2-IN-2 Inhibitor / 否
HY-156332 TNKS-2-IN-2 Inhibitor / 否
HY-23338 TNKS-2-IN-1 Inhibitor 95.77% 否
HY-RS14838 TNK2 Human Pre-designed siRNA Set A / 否
HY-RS14843 TNKS2 Human Pre-designed siRNA Set A / 否
HY-RS14844 Tnks2 Mouse Pre-designed siRNA Set A / 否
HY-RS14845 TNKS2 Rat Pre-designed siRNA Set A / 否
HY-153332 Tankyrase-IN-5 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus TNK2 VGNC VGNC:66420
Canis familiaris TNK2 VGNC VGNC:47680
Bos taurus TNK2 VGNC VGNC:36183
Mus musculus TNK2 MGD MGI:1858308
Rattus norvegicus TNK2 RGD RGD:1305957
Macaca mulatta TNK2 VGNC VGNC:79192
Others TNK2 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z