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  2. CDK7 - cyclin dependent kinase 7 Gene

CDK7 - cyclin dependent kinase 7 Gene

中文名称:细胞周期蛋白依赖性激酶 7

种属: Homo sapiens

同用名: CAK; CAK1; HCAK; MO15; STK1; CDKN7; p39MO15

基因 ID: 1022 | 基因类型: protein coding

关于 CDK7

Cytogenetic location: 5q13.2 Genomic coordinates (GRCh38): 5:69,234,795-69,277,430 (from NCBI)

This gene has 15 transcripts (splice variants), 1 gene allele, 207 orthologues and 26 paralogues. Ubiquitous expression in testis (RPKM 18.1), placenta (RPKM 14.9) and 25 other tissues.


该基因编码的蛋白质是细胞周期蛋白依赖性蛋白激酶 (CDK) 家族的成员。 CDK 家族成员与酿酒酵母 cdc28 和粟酒裂殖酵母 cdc2 的基因产物高度相似,并且已知是细胞周期进程的重要调节剂。该蛋白与细胞周期蛋白 H 和 MAT1 形成三聚体复合物,发挥 CDK 激活激酶 (CAK) 的作用。它是转录因子 TFIIH 的重要组成部分,参与转录起始和 DNA 修复。这种蛋白质被认为是转录调节和细胞周期之间的直接联系。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]

CDK7 基因产物(12)

mRNA Protein Name
NM_001324075.2 NP_001311004.1 cyclin-dependent kinase 7 isoform 4
NM_001324074.2 NP_001311003.1 cyclin-dependent kinase 7 isoform 4
NM_001324070.2 NP_001310999.1 cyclin-dependent kinase 7 isoform 3
NM_001324069.2 NP_001310998.1 cyclin-dependent kinase 7 isoform 2
NM_001324072.1 NP_001311001.1 cyclin-dependent kinase 7 isoform 4
NM_001324077.1 NP_001311006.1 cyclin-dependent kinase 7 isoform 4
XM_011543094.3 XP_011541396.1 cyclin-dependent kinase 7 isoform X2
NM_001324078.2 NP_001311007.1 cyclin-dependent kinase 7 isoform 4
NM_001324071.2 NP_001311000.1 cyclin-dependent kinase 7 isoform 5
NM_001799.4 NP_001790.1 cyclin-dependent kinase 7 isoform 1
XM_047416609.1 XP_047272565.1 cyclin-dependent kinase 7 isoform X1

CDK7 蛋白结构


Pkinase: Protein kinase domain (12 - 295)

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  • 346 a.a.
蛋白主名 其他名称

cyclin-dependent kinase 7

39 KDa protein kinase

CDK-activating kinase 1

TFIIH basal transcription factor complex kinase subunit

cell division protein kinase 7

cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)

homolog of Xenopus MO15 Cdk-activating kinase

kinase subunit of CAK

serine/threonine kinase stk1

serine/threonine protein kinase 1

serine/threonine protein kinase MO15

重组 CDK7 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75361 CDK7&CCNH&MNAT1 Protein, Human (sf9, His) P50613 (A2-F346)&P51946 (Y2-L323)&P51948 (D2-S309) ≥95%


疾病名称 别名
Cockayne Syndrome

Cockayne'S Syndrome

Dwarfism-Retinal Atrophy-Deafness Syndrome

Neill-Dingwall Syndrome

Progeria-Like Syndrome

Progeroid Nanism


Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast


Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation



Amish Brittle Hair Syndrome

Bids Syndrome

Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome



Trichothiodystrophy Syndromes

Xeroderma Pigmentosum, Complementation Group D

Xeroderma Pigmentosum, Group D


Xeroderma Pigmentosum Iv


Xeroderma Pigmentosum Group D

Xeroderma Pigmentosum Viii

Xp Group D

Xp Group H




Xp, Group D

Xp4 Xeroderma Pigmentosum Viii, Formerly

Xp8, Formerly

Xp, Group H, Formerly

Xph, Formerly

Xeroderma Pigmentosum Complementation Group D



Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum


Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

De Sanctis-Cacchione Syndrome


Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma


种属 基因名 来源 基因 ID
Mus musculus CDK7 MGD MGI:102956
Canis familiaris CDK7 VGNC VGNC:39060
Felis catus CDK7 VGNC VGNC:60705
Macaca mulatta CDK7 VGNC VGNC:84288
Bos taurus CDK7 VGNC VGNC:27134
Rattus norvegicus CDK7 RGD RGD:621124
Others CDK7 NCBI