GLYAT - glycine-N-acyltransferase Gene

中文名称：甘氨酸-N-酰基转移酶

种属: Homo sapiens

同用名: CAT; GAT; ACGNAT

基因 ID: 10249 | 基因类型: protein coding

关于 GLYAT

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:58,708,757-58,731,943 (from NCBI)

This gene has 6 transcripts (splice variants), 227 orthologues and 4 paralogues. Biased expression in kidney (RPKM 86.1), liver (RPKM 53.7) and 1 other tissue.

功能概要

甘氨酸-N-酰基转移酶蛋白使甘氨酸与线粒体中的酰基辅酶 A 底物结合。该蛋白质被认为在内源性和外源性酰基辅酶 A 的解毒中很重要。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2008 年 7 月]

The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GLYAT 基因产物(2)

mRNA	Protein	Name
NM_005838.4	NP_005829.3	glycine N-acyltransferase isoform b
NM_201648.3	NP_964011.2	glycine N-acyltransferase isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables glycine N-acyltransferase activity	IDA IDA: 通过直接分析推断	22475485	GOA
enables glycine N-benzoyltransferase activity	IDA IDA: 通过直接分析推断	22475485	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in benzoyl-CoA metabolic process	IDA IDA: 通过直接分析推断	22475485	GOA
involved in glycine metabolic process	IDA IDA: 通过直接分析推断	22475485	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in mitochondrion	IDA IDA: 通过直接分析推断	22475485	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GLYAT 蛋白结构

Gly_acyl_tr_N

Gly_acyl_tr_C

0
100
200
296 a.a.

蛋白主名

其他名称

glycine N-acyltransferase

AAc

GLYAT 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	GLYAT	Q6IB77	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
种属内	GLYAT	Q6IB77	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
种属内	GLYAT	Q6IB77	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Osteogenesis Imperfecta, Type I

Osteogenesis Imperfecta Type I	OI1
Oi, Type I	Osteogenesis Imperfecta Tarda
Osteogenesis Imperfecta With Blue Sclerae	Osteogenesis Imperfecta Type 1
Adair-Dighton Syndrome	Mild Osteogenesis Imperfecta
Non-Deforming Osteogenesis Imperfecta	Oi Type 1
Van Der Hoeve Syndrome	Classic Non-Deforming Oi With Blue Sclerae
Osteogenesis Imperfecta 1	Oi-I
Osteopenic Non-Fracture Syndrome	Osteogenesis Imperfecta, Mild
Osteogenesis Imperfecta	Lobstein'S Disease

Adenosquamous Prostate Carcinoma

Adenosquamous Carcinoma Of Prostate

Adenosquamous Carcinoma Of The Prostate

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05510	GLYAT Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	GLYAT	RGD	RGD:1307163
Canis familiaris	GLYAT	VGNC	VGNC:97198
Macaca mulatta	GLYAT	VGNC	VGNC:72937
Mus musculus	GLYAT	MGD	MGI:2147502

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