1. Gene
  2. SPRY1 - sprouty RTK signaling antagonist 1 Gene

SPRY1 - sprouty RTK signaling antagonist 1 Gene

中文名称:发芽的 RTK 信号拮抗因子 1

种属: Homo sapiens

同用名: hSPRY1

基因 ID: 10252 | 基因类型: protein coding

关于 SPRY1

Cytogenetic location: 4q28.1 Genomic coordinates (GRCh38): 4:123,396,795-123,403,760 (from NCBI)

This gene has 9 transcripts (splice variants), 188 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 30.2), gall bladder (RPKM 30.0) and 25 other tissues.


参与成纤维细胞生长因子受体信号通路的负调控。位于高尔基体;胞质溶胶;和核质。 [由基因组资源联盟提供,2022 年 4 月]

Involved in negative regulation of Fibroblast Growth Factor receptor signaling pathway. Located in Golgi apparatus; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SPRY1 基因产物(5)

mRNA Protein Name
NM_001258038.2 NP_001244967.1 protein sprouty homolog 1
NM_001258039.1 NP_001244968.1 protein sprouty homolog 1
NM_001375410.1 NP_001362339.1 protein sprouty homolog 1
NM_005841.3 NP_005832.1 protein sprouty homolog 1
NM_199327.3 NP_955359.1 protein sprouty homolog 1

SPRY1 蛋白结构


Sprouty: Sprouty protein (Spry) (186 - 298)

  • 0
  • 100
  • 200
  • 300
  • 319 a.a.
蛋白主名 其他名称

protein sprouty homolog 1

sprouty homolog 1, antagonist of FGF signaling


疾病名称 别名
Adrenal Cortical Adenocarcinoma

Adrenal Cortex Adenocarcinoma

Adrenocortical Carcinoma

Legius Syndrome

Neurofibromatosis Type 1-Like Syndrome



Neurofibromatosis 1-Like Syndrome

Neurofibromatosis Type 1 Like Syndrome

Nf1-Like Syndrome

Neurofibromatosis, Type 1-Like Syndrome

Colon Squamous Cell Carcinoma

Colonic Epidermoid Carcinoma

Squamous Cell Carcinoma Of Colon

Squamous Cell Carcinoma Of The Colon

Pulsating Exophthalmos
Noonan Syndrome With Multiple Lentigines

Leopard Syndrome

Multiple Lentigines Syndrome

Moynahan Syndrome

Cardiomyopathic Lentiginosis

Progressive Cardiomyopathic Lentiginosis

Cardio-Cutaneous Syndrome

Lentiginosis Profusa

Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome

Generalized Lentiginosis

Gorlin Syndrome Ii

Lentiginosis Profusa Syndrome

Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes

Diffuse Lentiginosis


Familial Multiple Lentigines Syndrome

Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type

Progressive Cardiomyopathic Lentiginosis Syndrome

Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan

Cardiofaciocutaneous Syndrome 1

Cardiofaciocutaneous Syndrome

Cfc Syndrome

Cardio-Facio-Cutaneous Syndrome



Cardio-Facial-Cutaneous Syndrome

Congenital Heart Defects Characteristic Facial Appearance Ectodermal Abnormalities And Growth Failure

Cardiofaciocutaneous Syndrome, Type 1


Ras/Mitogen-Activated Protein Kinase Syndrome

Renal Hypodysplasia/Aplasia 1

Renal Agenesis

Renal Adysplasia

Renal Aplasia


Hereditary Renal Aplasia


Hereditary Urogenital Adysplasia

Hypodysplasia/Aplasia, Renal, Type 1

Congenital Absence Of Kidneys Syndrome

Congenital Absence Of Kidney

Aplastic Kidney

Crouzon Syndrome

Crouzon Craniofacial Dysostosis

Craniofacial Dysostosis


Craniofacial Dysostosis Type 1

Crouzon Disease

Crouzon'S Disease

Craniofacial Dysostosis, Type I

Craniofacial Dysarthrosis

Craniofacial Dysostosis Syndrome


Craniofacial Dysostosis Type I

Vogt Cephalosyndactyly

Vesicoureteral Reflux

Vesico-Ureteral Reflux


Renal Or Urinary Tract Malformation

Congenital Anomalies Of Kidney And Urinary Tract

Congenital Anomaly Of Kidney And Urinary Tract

Congenital Anomalies Of The Kidney And Urinary Tract

Kidney And Urinary Tract, Anomalies, Congenital

Renal Hypodysplasia, Nonsyndromic, 1

Noonan Syndrome 1

Noonan Syndrome


Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome


Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma


种属 基因名 来源 基因 ID
Mus musculus SPRY1 MGD MGI:1345139
Macaca mulatta SPRY1 VGNC VGNC:77867
Rattus norvegicus SPRY1 RGD RGD:1309293
Bos taurus SPRY1 VGNC VGNC:35241
Felis catus SPRY1 VGNC VGNC:65649