2. Gene
  3. CNKSR1 - connector enhancer of kinase suppressor of Ras 1 Gene

CNKSR1 - connector enhancer of kinase suppressor of Ras 1 Gene

  • 基因
  • 蛋白
  • 直系同源

中文名称：Ras 1 激酶抑制因子的连接增强子

种属: Homo sapiens

同用名: CNK; CNK1

基因 ID: 10256 | 基因类型: protein coding

关于 CNKSR1

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,177,491-26,189,884 (from NCBI)

This gene has 14 transcripts (splice variants), 201 orthologues, 4 paralogues and is associated with 1 phenotype. Broad expression in skin (RPKM 7.6), thyroid (RPKM 6.2) and 20 other tissues.

功能概要

该基因编码的蛋白质包含多个参与蛋白质-蛋白质相互作用的基序，包括 PDZ、PH (Pleckstrin 同源性) 和 SAM (不育 alpha 基序) 结构域。编码的蛋白质充当受体酪氨酸激酶信号传导的支架成分，并可能介导不同信号通路之间的串扰。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 7 月]

This gene encodes a protein containing several motifs involved in protein-protein interaction, including PDZ, PH (Pleckstrin homology), and SAM (sterile alpha motif) domains. The encoded protein acts as a scaffold component for receptor tyrosine kinase signaling and may mediate crosstalk between different signaling pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

CNKSR1 基因产物(3)

mRNA Protein Name
NM_001297647.2 NP_001284576.1 connector enhancer of kinase suppressor of ras 1 isoform 2
NM_001297648.2 NP_001284577.1 connector enhancer of kinase suppressor of ras 1 isoform 3
NM_006314.3 NP_006305.2 connector enhancer of kinase suppressor of ras 1 isoform 1

CNKSR1 蛋白结构

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (6 - 67)

CRIC_ras_sig

CRIC_ras_sig: Connector enhancer of kinase suppressor of ras (78 - 162)

PH

PH: PH domain (406 - 502)

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  • 720 a.a.
蛋白主名 其他名称

connector enhancer of kinase suppressor of ras 1

CNK homolog protein 1

直系同源

种属 基因名 来源 基因 ID
Bos taurus CNKSR1 VGNC VGNC:97254
Rattus norvegicus CNKSR1 RGD RGD:1311879
Mus musculus CNKSR1 MGD MGI:2670958
Canis familiaris CNKSR1 VGNC VGNC:39403
Macaca mulatta CNKSR1 VGNC VGNC:71222
Felis catus CNKSR1 VGNC VGNC:61017