CLEC4M - C-type lectin domain family 4 member M Gene

中文名称：C 型凝集素结构域家族 4 成员 M

种属: Homo sapiens

同用名: CD299; LSIGN; CD209L; L-SIGN; DCSIGNR; HP10347; DC-SIGN2; DC-SIGNR

基因 ID: 10332 | 基因类型: protein coding

关于 CLEC4M

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:7,763,243-7,769,605 (from NCBI)

This gene has 7 transcripts (splice variants), 924 orthologues and 14 paralogues. Biased expression in liver (RPKM 15.4), lymph node (RPKM 9.8) and 3 other tissues.

功能概要

该基因编码一种 C 型凝集素，该凝集素在细胞粘附和病原体识别中发挥作用。这种受体识别范围广泛的对公共卫生有重大影响的进化不同的病原体，包括结核分枝杆菌和病毒，包括埃博拉病毒、丙型肝炎、HIV-1、甲型流感、西尼罗河病毒和 SARS-CoV 急性呼吸系统综合症冠状病毒。该蛋白质分为四个不同的结构域：C 末端碳水化合物识别结构域、可变长度的灵活串联重复颈部结构域、跨膜区域和参与内化的 N 末端胞质结构域。该基因在序列和功能方面与邻近基因 CD209 (基因 ID：30835) (也称为 DC-SIGN) 密切相关。这两个基因在病毒识别和表达模式方面存在差异，该基因在肝脏、淋巴结和胎盘的内皮细胞中表现出高表达。串联重复颈部结构域的多态性与对 SARS 感染的抵抗力有关。[RefSeq 提供，2020 年 5 月]

This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including tuberculosis mycobacteria, and viruses including Ebola, hepatitis C, HIV-1, influenza A, West Nile virus and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain of variable length, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CD209 (Gene ID: 30835), also known as DC-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression in endothelial cells of the liver, lymph node and placenta. Polymorphisms in the tandem repeat neck domain are associated with resistance to SARS Infection. [provided by RefSeq, May 2020]

CLEC4M 基因产物(9)

mRNA	Protein	Name
NM_001144904.2	NP_001138376.1	C-type lectin domain family 4 member M isoform 2
NM_001144905.2	NP_001138377.1	C-type lectin domain family 4 member M isoform 12
NM_001144906.2	NP_001138378.1	C-type lectin domain family 4 member M isoform 7
NM_001144907.2	NP_001138379.1	C-type lectin domain family 4 member M isoform 11
NM_001144908.2	NP_001138380.1	C-type lectin domain family 4 member M isoform 10
NM_001144909.2	NP_001138381.1	C-type lectin domain family 4 member M isoform 9
NM_001144910.2	NP_001138382.1	C-type lectin domain family 4 member M isoform 8
NM_001144911.2	NP_001138383.1	C-type lectin domain family 4 member M isoform 3
NM_014257.5	NP_055072.3	C-type lectin domain family 4 member M isoform 1

CLEC4M 蛋白结构

Lectin_C

0
100
200
300
399 a.a.

蛋白主名

其他名称

C-type lectin domain family 4 member M

CD209 antigen-like protein 1

重组 CLEC4M 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72739	CD299 Protein, Human (HEK293, His-Flag)	Q9H2X3-8 (S73-E376)	≥95%
HY-P76218	CD299 Protein, Human (HEK293)	Q9H2X3 (Q71-E399)	≥95%
HY-P76219	CD299 Protein, Human (HEK293, Fc)	Q9H2X3-1/NP_055072.3 (S78-E399)	≥95%

关联疾病

疾病名称

别名

West Nile Virus

West Nile Virus, Susceptibility To	Wnv
Wnv, Susceptibility To	West Nile Viral Infection
Encephalitis, West Nile Fever	West Nile Fever

Japanese Encephalitis

Japanese B Encephalitis	Je
Encephalitis Japanese	Encephalitis, Japanese
Russian Autumnal Encephalitis	Je - [Japanese Encephalitis]
Japanese Encephalitis Virus Disease	Jbe - [Japanese B Encephalitis}
B Type Encephalitis

Hepatitis C

Chronic Hepatitis C	Hepatitis C Infection
Hepatitis Nona Nonb	Nanbh
Viral Hepatitis C	Hepatitis C Chronic
Hepatitis C, Chronic	Chronic Type C Viral Hepatitis
Chronic Hcv - [Hepatitis C Virus] Infection	Hepatitis C Nos
Hepatitis C Infection Nos	Hepatitis C-Related Cirrhosis
Type C Viral Hepatitis	Hep C Nos

Encephalitis

Mumps Encephalitis	Mumps Meningoencephalitis
Herpes Simplex Neuroinvasion	Herpetic Encephalitis
Herpetic Encephalopathy	Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis
Encephalitis Due To Herpesviridae	Encephalitis Due To Herpesvirus
Herpes Encephalitis	Herpesviral Encephalitis
Herpes Simplex Encephalitis	Hsv - [Herpes Simplex Virus] Encephalitis
Herpes Virus Encephalitis	Simian B Disease
Simian B Disorder	Encephalitis Nec
Idiopathic Encephalitis

Hepatitis

Chronic Hepatitis	Chronic Persistent Hepatitis
Acute Hepatitis	Hepatitis, Chronic
Acute And Subacute Liver Necrosis	Acute/Subac. Necrosis Of Liver
Animal Hepatitis	Hepatitis Chronic
Hepatitis A	Hepatitis, Animal
Hepatitis Due To Toxoplasmosis	Hepatitis In Toxoplasmosis
Toxoplasmal Hepatitis	Chronic Hepatitis, Unspecified
Chronic Active Hepatitis Nec	Other Specified Chronic Hepatitis
Chronic Persistent Hepatitis Nec	Chronic Lobular Hepatitis Nec

Hepatitis C Virus

Hepatitis C Virus, Susceptibility To	Hepatitis C Virus Infection, Response To Therapy Of
Hcv	Hcv, Susceptibility To
Hepatitis C Virus, Resistance To	Hepatitis C Virus, Response To Therapy Of
Resistance To Hepatitis C Virus

Severe Acute Respiratory Syndrome

Sars	Sars-Cov Infection
Sars-1	Sar Deficiency
Sars - [Severe Acute Respiratory Syndrome]

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Marburg Hemorrhagic Fever

Marburg Virus Disease	Marburg Disease
Green Monkey Disease	Mhf
Vervet Monkey Disease	Mard - [Marburg Disease]
Mvd - [Marburg Virus Disease]	Marburg Haemorrhagic Fever
Mhf - [Marburg Haemorrhagic Fever]

Disease By Infectious Agent

Infectious Disease

Infectious Diseases

Von Willebrand Disease, Type 1

Von Willebrand Disease Type 1	VWD1
Von Willebrand'S Disease 1	Von Willebrand Disease Type I
Von Willebrand Disease, Type I	Vwd, Type 1
Vwd Type 1	Von Willebrand Disease 1
Von Willebrand Factor Deficiency Type 1	Von Willebrand Disease, Type 1, Susceptibility To

Viral Infectious Disease

Viral Disease	Arbovirus Infections
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

Ebola Hemorrhagic Fever

Ebola Virus Disease	Viral Hemorrhagic Fever
Hemorrhagic Fever, Ebola	Ebola
Ehf	Ebola Fever
Hemorrhagic Fevers, Viral	Ebola Haemorrhagic Fever
Ebod - [Ebola Disease]	Evd - [Ebola Virus Disease]
Ebola Virus Haemorrhagic Fever	Vhf - [Viral Haemorrhagic Fever] Nos
Viral Haemorrhagic Fever, Not Otherwise Specified

Human Immunodeficiency Virus Infectious Disease

Hiv Infections

West Nile Fever

Dengue Hemorrhagic Fever

Severe Dengue	Dengue Haemorrhagic Fever
Dhf	Severe Dengue Haemorrhagic Fever
Severe Dengue Fever	Dengue Shock Syndrome

Argentine Hemorrhagic Fever

Argentinian Hemorrhagic Fever	Junin Hemorrhagic Fever
Hemorrhagic Fever, Argentinian	Ahf - [Argentinian Haemorrhagic Fever]
Argentine Haemorrhagic Fever	Junin Haemorrhagic Fever

Dengue Shock Syndrome

Dss

Tick-Borne Encephalitis

Siberian Tick-Borne Encephalitis	Encephalitis, Tick-Borne
Central European Encephalitis	Far Eastern Tbe
Russian Spring-Summer Encephalitis	Taiga Encephalitis
West-Siberian Encephalitis	Western European Tick-Borne Encephalitis
Tbe	Encephalitis Tick-Borne
Encephalitis, Central European	Encephalitis, Far Eastern Russian

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Coronavirus Infectious Disease

Factor Viii Deficiency

Autosomal Hemophilia A	Hemophilia A
Autosomal Factor Viii Deficiency	Classic Hemophilia A
Congenital Factor Viii Disorder	Subhemophilia
Factor 8 Deficiency, Congenital	Factor Viii

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02797	CLEC4M Human Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	CLEC4M	RGD	RGD:1561466
Others	CLEC4M	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

站点地图隐私声明

CLEC4M - C-type lectin domain family 4 member M Gene

关于 CLEC4M

功能概要

CLEC4M 基因产物(9)

CLEC4M 蛋白结构

重组 CLEC4M 蛋白

关联疾病

直系同源

热门区域

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CLEC4M - C-type lectin domain family 4 member M Gene

关于 CLEC4M

功能概要

CLEC4M 基因产物(9)

CLEC4M 蛋白结构

重组 CLEC4M 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z