1. Signaling Pathways
  2. Anti-infection
  3. SARS-CoV

SARS-CoV

SARS-CoV (SARS coronavirus) is the virus that causes severe acute respiratory syndrome (SARS). Coronaviruses encode papain-like proteases (PLpro) that are often multifunctional enzymes with protease activity to process the viral replicase polyprotein and deubiquitinating (DUB)/deISGylating activity, which is hypothesized to modify the innate immune response to infection.

SARS-CoV 相关产品 (4):

Cat. No. Product Name Effect Purity
  • HY-104077
    Remdesivir Inhibitor 98.30%
    Remdesivir (GS-5734) 是一种核苷类似物,具有抗病毒活性,在 HAE 细胞中,对 SARS-CoVMERS-CoVEC50 值为 74 nM,在延迟脑肿瘤细胞中,对鼠肝炎病毒的 EC50 值为 30 nM。
  • HY-13765
    6-Thioguanine Inhibitor >98.0%
    6-Thioguanine (Thioguanine) 是一种抗白血病和免疫抑制剂,为 SARS 和 MERS 冠状病毒木瓜样蛋白酶 (PLpros) 的抑制剂,同时可有效抑制 USP2 的活性,IC50 值分别为 25 μM 和 40 μM。
  • HY-N1910
    4'-O-Methylbavachalcone Inhibitor
    4'-O-Methylbavachalcone 是从补骨脂中分离得到的查尔酮类,可抑制严重急性呼吸综合征冠状病毒 (SARS-CoV) 木瓜样蛋白酶 (PLpro) 的活性,IC50 值为 10.1 μM。
  • HY-17542
    PLpro inhibitor Inhibitor 99.79%
    PLpro inhibitor是PLpro抑制剂,IC50为2.6 uM。
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