2. Gene
  3. BASP1 - brain abundant membrane attached signal protein 1 Gene

BASP1 - brain abundant membrane attached signal protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：脑富集膜附着信号蛋白 1

种属: Homo sapiens

同用名: CAP23; NAP22; CAP-23; NAP-22

基因 ID: 10409 | 基因类型: protein coding

关于 BASP1

Cytogenetic location: 5p15.1 Genomic coordinates (GRCh38): 5:17,216,823-17,276,834 (from NCBI)

This gene has 3 transcripts (splice variants) and 110 orthologues. Biased expression in brain (RPKM 144.2), prostate (RPKM 45.3) and 10 other tissues.

功能概要

该基因编码具有多个瞬时磷酸化位点和 PEST 基序的膜结合蛋白。不同物种之间具有 PEST 序列的蛋白质的保存支持它们的功能意义。 PEST 序列通常出现在具有高周转率的蛋白质中。这种蛋白质的免疫学特征是物种特异性的。该蛋白质还经历 N 末端豆蔻酰化。可变剪接导致编码相同蛋白质的多个转录变体。[RefSeq 提供，2012 年 10 月]

This gene encodes a membrane bound protein with several transient phosphorylation sites and PEST motifs. Conservation of proteins with PEST sequences among different species supports their functional significance. PEST sequences typically occur in proteins with high turnover rates. Immunological characteristics of this protein are species specific. This protein also undergoes N-terminal myristoylation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2012]

BASP1 基因产物(2)

mRNA Protein Name
NM_001271606.2 NP_001258535.1 brain acid soluble protein 1
NM_006317.5 NP_006308.3 brain acid soluble protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calmodulin binding IDA
IDA: 通过直接分析推断
32750402 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
14701728 GOA
enables transcription corepressor activity IMP
IMP: 通过突变表型推断
14701728 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
19050011 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
14701728 GOA
involved in protein homooligomerization IDA
IDA: 通过直接分析推断
32750402 GOA
involved in supramolecular fiber organization IDA
IDA: 通过直接分析推断
32750402 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of COP9 signalosome IDA
IDA: 通过直接分析推断
18850735 GOA
located in PML body IDA
IDA: 通过直接分析推断
19050011 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
14701728 GOA
located in nuclear matrix IDA
IDA: 通过直接分析推断
19050011 GOA
located in nucleus IDA
IDA: 通过直接分析推断
14701728 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BASP1 蛋白结构

BASP1

BASP1: Brain acid soluble protein 1 (BASP1 protein) (2 - 227)

  • 0
  • 100
  • 200
  • 227 a.a.
蛋白主名 其他名称

brain acid soluble protein 1

22 kDa neuronal tissue-enriched acidic protein

关联疾病

疾病名称 别名
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01370 BASP1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20368 Basp1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26878 Basp1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta BASP1 VGNC VGNC:70228
Bos taurus BASP1 VGNC VGNC:106649
Rattus norvegicus BASP1 RGD RGD:621491
Mus musculus BASP1 MGD MGI:1917600
Canis familiaris BASP1 VGNC VGNC:38384
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