RBM14 - RNA binding motif protein 14 Gene

中文名称：RNA 结合基序蛋白 14

种属: Homo sapiens

同用名: SIP; COAA; PSP2; SYTIP1; TMEM137

关于 RBM14

功能概要

该基因编码一种核糖核蛋白，作为一般核共激活因子和 RNA 剪接调节剂发挥作用。该蛋白质在 N 端包含两个 RNA 识别基序 (RRM) ，在 C 端包含多个六肽重复结构域，与甲状腺激素受体结合蛋白 (TRBP) 相互作用，是转录激活所必需的。已经针对该基因描述了编码不同同种型 (对转录具有相反作用) 的选择性剪接转录物变体。[RefSeq 提供，2011 年 10 月]

This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]