GLRX3 - glutaredoxin 3 Gene

中文名称：谷氧还蛋白 3

种属: Homo sapiens

同用名: GRX3; GRX4; GLRX4; PICOT; TXNL2; TXNL3

基因 ID: 10539 | 基因类型: protein coding

关于 GLRX3

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:130,136,391-130,180,377 (from NCBI)

This gene has 6 transcripts (splice variants), 217 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 12.3), lymph node (RPKM 8.3) and 25 other tissues.

功能概要

该基因编码谷氧还蛋白家族的一个成员。谷氧还蛋白是使用谷胱甘肽作为辅助因子来还原多种底物的氧化还原酶。编码的蛋白质结合并调节蛋白激酶 C theta 的功能。编码的蛋白质也可能抑制细胞凋亡并在细胞生长中发挥作用，该基因的表达可能是癌症的标志。该基因的假基因位于 6 号和 9 号染色体的短臂上。已观察到该基因的选择性剪接转录变体。[RefSeq 提供，2010 年 12 月]

This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase Enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit Apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for Cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

GLRX3 基因产物(3)

mRNA	Protein	Name
NM_001199868.2	NP_001186797.1	glutaredoxin-3 isoform 1
NM_001321980.2	NP_001308909.1	glutaredoxin-3 isoform 2
NM_006541.5	NP_006532.2	glutaredoxin-3 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10636891	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in [2Fe-2S] cluster assembly	IDA IDA: 通过直接分析推断	27519415	GOA
involved in cell redox homeostasis	IDA IDA: 通过直接分析推断	27519415	GOA
involved in intracellular iron ion homeostasis	IDA IDA: 通过直接分析推断	27519415	GOA
involved in iron-sulfur cluster assembly	IDA IDA: 通过直接分析推断	27519415	GOA
involved in protein maturation by iron-sulfur cluster transfer	IDA IDA: 通过直接分析推断	27519415	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of iron-sulfur cluster assembly complex	IPI IPI: 通过物理相互作用推断	22309771	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GLRX3 蛋白结构

Thioredoxin

Glutaredoxin

0
100
200
300
335 a.a.

蛋白主名

其他名称

glutaredoxin-3

PKC-interacting cousin of thioredoxin

GLRX3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	GLRX3	O76003	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	32296183
种属内	GLRX3	O76003	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
种属内	GLRX3	O76003	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	25416956
种属内	GLRX3	O76003	KRTAP10-9	Homo sapiens	P60411	Validated Y2H	32296183
种属内	GLRX3	O76003	KRTAP10-5	Homo sapiens	P60370	Y2H Prey Pooling	25416956
种属内	GLRX3	O76003	KRTAP10-5	Homo sapiens	P60370	Validated Y2H	25416956
种属内	GLRX3	O76003	KRTAP10-5	Homo sapiens	P60370	Validated Y2H	32296183
种属内	GLRX3	O76003	KRTAP4-2	Homo sapiens	Q9BYR5	Validated Y2H	25416956
种属内	GLRX3	O76003	KRTAP10-11	Homo sapiens	P60412	MAPPIT	25416956
种属内	GLRX3	O76003	KRTAP10-11	Homo sapiens	P60412	Validated Y2H	25416956
种属内	GLRX3	O76003	KRTAP10-11	Homo sapiens	P60412	Y2H Prey Pooling	25416956
种属内	GLRX3	O76003	ADAMTSL3	Homo sapiens	P82987	Validated Y2H	32296183
种属内	GLRX3	O76003	LCE2D	Homo sapiens	Q5TA82	Validated Y2H	32296183
种属内	GLRX3	O76003	LCE2D	Homo sapiens	Q5TA82	Validated Y2H	25416956
种属内	GLRX3	O76003	KRTAP5-6	Homo sapiens	Q6L8G9	Y2H Prey Pooling	25416956
种属内	GLRX3	O76003	KRTAP5-6	Homo sapiens	Q6L8G9	Validated Y2H	25416956
种属内	GLRX3	O76003	KRTAP5-6	Homo sapiens	Q6L8G9	Validated Y2H	32296183
种属内	GLRX3	O76003	ZNF774	Homo sapiens	Q6NX45	Validated Y2H	32296183
种属内	GLRX3	O76003	RECK	Homo sapiens	Q6P9E2	Validated Y2H	32296183
种属内	GLRX3	O76003	TMEM25	Homo sapiens	Q86YD3	Validated Y2H	25416956
种属内	GLRX3	O76003	OLFM3	Homo sapiens	Q96PB7	Y2H Prey Pooling	25416956
种属内	GLRX3	O76003	OLFM3	Homo sapiens	Q96PB7	Validated Y2H	25416956
种属内	GLRX3	O76003	KRTAP4-11	Homo sapiens	Q9BYQ6	Validated Y2H	32296183
种属内	GLRX3	O76003	KRTAP4-11	Homo sapiens	Q9BYQ6	Y2H Prey Pooling	25416956
种属内	GLRX3	O76003	KRTAP4-11	Homo sapiens	Q9BYQ6	Y2H Array	25416956
种属内	GLRX3	O76003	KRTAP4-7	Homo sapiens	Q9BYR0	Validated Y2H	25416956
种属内	GLRX3	O76003	KRTAP4-7	Homo sapiens	Q9BYR0	Y2H Array	25416956
种属内	GLRX3	O76003	KRTAP4-7	Homo sapiens	Q9BYR0	Y2H Prey Pooling	25416956
种属内	GLRX3	O76003	IL10	Homo sapiens	P22301	Validated Y2H	32296183
种属内	GLRX3	O76003	KRTAP9-3	Homo sapiens	Q9BYQ3	Validated Y2H	32296183
种属内	GLRX3	O76003	KRTAP9-2	Homo sapiens	Q9BYQ4	Validated Y2H	32296183
种属内	GLRX3	O76003	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	25416956
种属内	GLRX3	O76003	KRT38	Homo sapiens	O76015	Y2H Prey Pooling	25416956
种属内	GLRX3	O76003	KRT38	Homo sapiens	O76015	Validated Y2H	25416956
种属内	GLRX3	O76003	BOLA1	Homo sapiens	Q9Y3E2	Anti Tag CoIP	33961781
种属内	GLRX3	O76003	BOLA1	Homo sapiens	Q9Y3E2	Anti Tag CoIP	28514442
种属内	GLRX3	O76003	BOLA1	Homo sapiens	Q9Y3E2	Y2H Prey Pooling	25416956
种属内	GLRX3	O76003	BOLA1	Homo sapiens	Q9Y3E2	Validated Y2H	32296183
种属内	GLRX3	O76003	BOLA1	Homo sapiens	Q9Y3E2	Y2H Array	25416956
种属内	GLRX3	O76003	METAP1	Homo sapiens	P53582	Validated Y2H	32296183
种属内	GLRX3	O76003	RGS20	Homo sapiens	O76081	Y2H Prey Pooling	25416956
种属内	GLRX3	O76003	KPRP	Homo sapiens	Q5T749	Validated Y2H	32296183
种属内	GLRX3	O76003	ZNF490	Homo sapiens	Q9ULM2	Validated Y2H	32296183
种属内	GLRX3	O76003	GNG13	Homo sapiens	Q9P2W3	Validated Y2H	32296183
种属内	GLRX3	O76003	ZNF410	Homo sapiens	Q86VK4-3	Validated Y2H	32296183
种属内	GLRX3	O76003	KRTAP12-3	Homo sapiens	P60328	Validated Y2H	32296183
种属内	GLRX3	O76003	KRTAP4-4	Homo sapiens	Q9BYR3	Validated Y2H	32296183
种属内	GLRX3	O76003	KRTAP9-8	Homo sapiens	Q9BYQ0	Validated Y2H	32296183
种属内	GLRX3	O76003	KRTAP5-4	Homo sapiens	Q6L8H1	Validated Y2H	32296183
种属内	GLRX3	O76003	KRTAP5-3	Homo sapiens	Q6L8H2	Validated Y2H	32296183
种属内	GLRX3	O76003	KRTAP5-3	Homo sapiens	Q6L8H2	Y2H Array	32296183
种属内	GLRX3	O76003	CDC20B	Homo sapiens	Q86Y33-5	Validated Y2H	32296183
种属内	GLRX3	O76003	KRTAP4-5	Homo sapiens	Q9BYR2	Validated Y2H	32296183
种属内	GLRX3	O76003	KRTAP5-11	Homo sapiens	Q6L8G4	Validated Y2H	32296183
种属内	GLRX3	O76003	BOLA3	Homo sapiens	Q53S33	Validated Y2H	32296183
种属内	GLRX3	O76003	IRX6	Homo sapiens	P78412	Validated Y2H	32296183
种属内	GLRX3	O76003	STRA6	Homo sapiens	Q9BX79-6	Validated Y2H	32296183
种属内	GLRX3	O76003	KLHDC9	Homo sapiens	Q8NEP7	Validated Y2H	32296183
种属内	GLRX3	O76003	CA9	Homo sapiens	Q16790	Validated Y2H	32296183
种属内	GLRX3	O76003	CERCAM	Homo sapiens	Q5T4B2	Validated Y2H	32296183
种属内	GLRX3	O76003	RCOR3	Homo sapiens	Q9P2K3-2	Validated Y2H	32296183
种属内	GLRX3	O76003	CIAPIN1	Homo sapiens	Q6FI81-1	NMR	26302480
种属内	GLRX3	O76003	CIAPIN1	Homo sapiens	Q6FI81-1	GMS	26302480
种属内	GLRX3	O76003	BOLA2	Homo sapiens	Q9H3K6	Anti Tag CoIP	33961781
种属内	GLRX3	O76003	BOLA2	Homo sapiens	Q9H3K6	Anti Tag CoIP	27519415
种属内	GLRX3	O76003	HEPH	Homo sapiens	Q9BQS7-3	Validated Y2H	32296183
种属内	GLRX3	O76003	TRIM36	Homo sapiens	Q9NQ86	Validated Y2H	32296183
种属内	GLRX3	O76003	TRIM36	Homo sapiens	Q9NQ86	Y2H Array	25416956
种属内	GLRX3	O76003	TRIM36	Homo sapiens	Q9NQ86	Validated Y2H	25416956
种属内	GLRX3	O76003	ZNF124	Homo sapiens	Q15973	Validated Y2H	32296183
种属内	GLRX3	O76003	ZNF148	Homo sapiens	Q9UQR1	Y2H Prey Pooling	25416956
种属内	GLRX3	O76003	SMARCC1	Homo sapiens	Q92922	Validated Y2H	32296183
种属内	GLRX3	O76003	PFDN5	Homo sapiens	Q99471	Y2H Prey Pooling	25416956
种属内	GLRX3	O76003	PFDN5	Homo sapiens	Q99471	Y2H Array	25416956
种属内	GLRX3	O76003	TRAF1	Homo sapiens	Q13077	Y2H Array	25416956
种属内	GLRX3	O76003	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	25416956
种属内	GLRX3	O76003	TRAF1	Homo sapiens	Q13077	BFG-2H	27107012
种属内	GLRX3	O76003	TRAF1	Homo sapiens	Q13077	Validated Y2H	27107012
种属内	GLRX3	O76003	PRKCQ	Homo sapiens	Q04759	Y2H	10636891
种属内	GLRX3	O76003	PRKCQ	Homo sapiens	Q04759	Pull Down	10636891
种属内	GLRX3	O76003	PRKCQ	Homo sapiens	Q04759	Imaging	10636891
种属内	GLRX3	O76003	CIAPIN1	Homo sapiens	Q6FI81	Validated Y2H	25416956
种属内	GLRX3	O76003	CIAPIN1	Homo sapiens	Q6FI81	Validated Y2H	32296183
种属内	GLRX3	O76003	CIAPIN1	Homo sapiens	Q6FI81	Y2H Array	25416956
种属内	GLRX3	O76003	CIAPIN1	Homo sapiens	Q6FI81	Y2H Pooling	16189514
种属内	GLRX3	O76003	CIAPIN1	Homo sapiens	Q6FI81	Anti Tag CoIP	33961781
种属内	GLRX3	O76003	CIAPIN1	Homo sapiens	Q6FI81	Y2H	21516116
种属内	GLRX3	O76003	CIAPIN1	Homo sapiens	Q6FI81	Y2H Array	31515488
种属内	GLRX3	O76003	CIAPIN1	Homo sapiens	Q6FI81	Y2H Prey Pooling	25416956
种属内	GLRX3	O76003	CIAPIN1	Homo sapiens	Q6FI81	BiFC	25416956
种属内	GLRX3	O76003	NTF4	Homo sapiens	P34130	Validated Y2H	32296183
种属内	GLRX3	O76003	HSD3B7	Homo sapiens	Q9H2F3	Validated Y2H	32296183
种属内	GLRX3	O76003	KRTAP5-9	Homo sapiens	P26371	Validated Y2H	25416956
种属内	GLRX3	O76003	KRTAP5-9	Homo sapiens	P26371	Validated Y2H	32296183
种属内	GLRX3	O76003	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	25416956
种属内	GLRX3	O76003	KRTAP5-9	Homo sapiens	P26371	Y2H Array	25416956
种属内	GLRX3	O76003	TRIM42	Homo sapiens	Q8IWZ5	Validated Y2H	25416956
种属内	GLRX3	O76003	TRIM42	Homo sapiens	Q8IWZ5	Y2H Array	25416956
种属内	GLRX3	O76003	MOXD1	Homo sapiens	Q6UVY6	Validated Y2H	32296183
种属内	GLRX3	O76003	MOXD1	Homo sapiens	Q6UVY6	Validated Y2H	25416956
种属内	GLRX3	O76003	MOXD1	Homo sapiens	Q6UVY6	Y2H Prey Pooling	25416956
种属内	GLRX3	O76003	MOXD1	Homo sapiens	Q6UVY6	Y2H Array	25416956
种属内	GLRX3	O76003	CGGBP1	Homo sapiens	Q9UFW8	Y2H Array	25416956
种属内	GLRX3	O76003	CGGBP1	Homo sapiens	Q9UFW8	Y2H Prey Pooling	25416956
种属内	GLRX3	O76003	CGGBP1	Homo sapiens	Q9UFW8	Validated Y2H	25416956
种属内	GLRX3	O76003	SOX7	Homo sapiens	Q9BT81	Validated Y2H	25416956
种属内	GLRX3	O76003	SOX7	Homo sapiens	Q9BT81	Y2H Array	25416956
种属内	GLRX3	O76003	TCL1B	Homo sapiens	O95988	Validated Y2H	32296183
种属内	GLRX3	O76003	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
种属内	GLRX3	O76003	KRTAP4-12	Homo sapiens	Q9BQ66	Y2H Pooling	16189514
种属内	GLRX3	O76003	KRTAP4-12	Homo sapiens	Q9BQ66	Validated Y2H	32296183
种属内	GLRX3	O76003	KRTAP4-12	Homo sapiens	Q9BQ66	Y2H Array	25416956
种属内	GLRX3	O76003	PLSCR1	Homo sapiens	O15162	Y2H Array	25416956
种属内	GLRX3	O76003	ZNF426	Homo sapiens	Q9BUY5	Y2H Array	25416956
种属内	GLRX3	O76003	ZNF426	Homo sapiens	Q9BUY5	Validated Y2H	25416956
种属内	GLRX3	O76003	UGP2	Homo sapiens	Q16851	Y2H Prey Pooling	25416956
种属内	GLRX3	O76003	CBLB	Homo sapiens	Q13191	Validated Y2H	25416956
种属内	GLRX3	O76003	IKZF1	Homo sapiens	Q13422	Y2H Prey Pooling	25416956
种属内	GLRX3	O76003	IKZF1	Homo sapiens	Q13422	Validated Y2H	25416956
种属内	GLRX3	O76003	COL8A1	Homo sapiens	P27658	Validated Y2H	32296183
种属内	GLRX3	O76003	GRN	Homo sapiens	P28799	Y2H Array	31515488
种属内	GLRX3	O76003	GRN	Homo sapiens	P28799	Y2H Prey Pooling	25416956
种属内	GLRX3	O76003	GRN	Homo sapiens	P28799	Y2H Array	25416956
种属内	GLRX3	O76003	GRN	Homo sapiens	P28799	Y2H	21516116
种属内	GLRX3	O76003	GRN	Homo sapiens	P28799	Validated Y2H	25416956
种属内	GLRX3	O76003	PCSK5	Homo sapiens	Q92824	Validated Y2H	25416956
种属内	GLRX3	O76003	FAM118A	Homo sapiens	Q9NWS6	Y2H Array	25416956
种属内	GLRX3	O76003	MAPKBP1	Homo sapiens	O60336	Y2H Array	25416956
种属内	GLRX3	O76003	MAPKBP1	Homo sapiens	O60336	Y2H Prey Pooling	25416956
种属内	GLRX3	O76003	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

X-Linked Intellectual Disability-Short Stature-Overweight Syndrome

Mrx12	Mrx35
X-Linked Mental Retardation 12	X-Linked Mental Retardation 35

Transvestism

Dual-Role Transvestism	Fetishistic Transvestism
Cross Dresser	Transvestic Fetishism

Friedreich Ataxia

Friedreich Ataxia 1	FRDA
Friedreich Ataxia With Retained Reflexes	Frda1
Fa	Friedreich'S Ataxia
Hereditary Spinal Ataxia	Fa1
Friedreich'S Tabes	Hereditary Spinal Sclerosis
Spinocerebellar Ataxia, Friedreich	Friedreich Spinocerebellar Ataxia
Friedrich'S Ataxia

Transposition Of The Great Arteries, Dextro-Looped

Transposition Of The Great Arteries	DTGA1
Dextro-Looped Transposition Of The Great Arteries	DTGA
Congenitally Uncorrected Transposition Of The Great Arteries	Congenitally Uncorrected Transposition Of The Great Vessels
D-Tga	Isolated Ventriculoarterial Discordance
Ventriculoarterial Discordance With Atrioventricular Concordance	Dextro-Transposition Of The Great Arteries
Transposition Of The Great Vessels	Great Vessels Transposition
Transposition Of The Great Arteries, Dextro-Looped 1	Arteries, Great, Transposition, Dextro-Looped
Ventriculoarterial Discordance, Isolated	D-Transposition Of The Great Arteries
Complete Transposition	Tga
Tgv	Transposition Of Great Vessels
Transposition Of The Great Arteries Dextro-Looped 1	Dextro-Looped Transposition Of The Great Arteries 1
Discordant Ventriculoarterial Connection	Complete Transposition Of Great Vessels
Great Vessels Complete Transposition	Total Great Vessel Transposition
Transposition Of Great Arteries	Complete Tga - [Transposition Of The Great Arteries]
Tga - [Transposition Of Great Arteries]	Tgv - [Transposition Of Great Vessels]
Transposition Of Great Vessels Nos	Transposed Vessels Nos

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05498	GLRX3 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	GLRX3	MGD	MGI:1353653
Macaca mulatta	GLRX3	VGNC	VGNC:103820
Rattus norvegicus	GLRX3	RGD	RGD:69414
Canis familiaris	GLRX3	VGNC	VGNC:41275
Bos taurus	GLRX3	VGNC	VGNC:29417

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

GLRX3 - glutaredoxin 3 Gene

关于 GLRX3

功能概要

GLRX3 基因产物(3)

GLRX3 蛋白结构

GLRX3 蛋白互作信息

关联疾病

直系同源

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GLRX3 - glutaredoxin 3 Gene

关于 GLRX3

功能概要

GLRX3 基因产物(3)

GLRX3 蛋白结构

GLRX3 蛋白互作信息

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