2. Gene
  3. AKAP3 - A-kinase anchoring protein 3 Gene

AKAP3 - A-kinase anchoring protein 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：A-激酶锚定蛋白 3

种属: Homo sapiens

同用名: CT82; SOB1; FSP95; PRKA3; HEL159; AKAP110; AKAP 110

基因 ID: 10566 | 基因类型: protein coding

关于 AKAP3

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:4,615,518-4,649,051 (from NCBI)

This gene has 6 transcripts (splice variants), 110 orthologues and 3 paralogues. Restricted expression toward testis (RPKM 61.9).

功能概要

该基因编码 A 激酶锚定蛋白 (AKAP) 的成员，AKAP 是功能相关的蛋白质家族，可将蛋白激酶 A 靶向细胞内的离散位置。据报道，编码的蛋白质参与与蛋白激酶 A 的 R 亚基以及精子相关蛋白的蛋白质-蛋白质相互作用。这种蛋白质在精子中表达并定位于精子头部的顶体区域以及主要部分的长度。它可以作为运动、获能和顶体反应的调节剂发挥作用。[RefSeq 提供，2013 年 5 月]

This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is reported to participate in protein-protein interactions with the R-subunit of the protein kinase A as well as sperm-associated proteins. This protein is expressed in spermatozoa and localized to the acrosomal region of the sperm head as well as the length of the principal piece. It may function as a regulator of motility, capacitation, and the acrosome reaction. [provided by RefSeq, May 2013]

AKAP3 基因产物(2)

mRNA Protein Name
NM_001278309.2 NP_001265238.2 A-kinase anchor protein 3
NM_006422.4 NP_006413.4 A-kinase anchor protein 3

AKAP3 蛋白结构

RII_binding_1

RII_binding_1: RII binding domain (123 - 140)

AKAP_110

AKAP_110: A-kinase anchor protein 110 kDa (AKAP 110) (166 - 853)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 853 a.a.
蛋白主名 其他名称

A-kinase anchor protein 3

A kinase (PRKA) anchor protein 3

关联疾病

疾病名称 别名
Spermatogenic Failure 9

Male Infertility Due To Globozoospermia

SPGF9

Male Infertility Due To Round-Headed Spermatozoa

Globozoospermia, Complete

Globozoospermia, Total

Globozoospermia

Globozoospermia Syndrome

Round-Headed Sperm Syndrome

Globozoospermia Complete

Globozoospermia Total
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Vas Deferens, Congenital Bilateral Aplasia Of

Congenital Bilateral Absence Of Vas Deferens

CBAVD

Cavd

Congenital Bilateral Aplasia Of Vas Deferens

Congenital Bilateral Absence Of The Vas Deferens

Congenital Bilateral Agenesis Of Vas Deferens

Absence Of Vas Deferens

Absent Vasa

Congenital Absence Of Vas Deferens

Congenital Aplasia Of Vas Deferens

Absent Vas Deferens

Vas Deferens, Congenital Bilateral Absence
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00518 AKAP3 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus AKAP3 VGNC VGNC:59713
Rattus norvegicus AKAP3 RGD RGD:1359735
Mus musculus AKAP3 MGD MGI:1341149
Macaca mulatta AKAP3 VGNC VGNC:69769
Bos taurus AKAP3 VGNC VGNC:25784
Canis familiaris AKAP3 VGNC VGNC:37756
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