CES1 - carboxylesterase 1 Gene

中文名称：羧酸酯酶 1

种属: Homo sapiens

同用名: CEH; REH; TGH; ACAT; CE-1; CES2; HMSE; SES1; HMSE1; PCE-1; hCE-1

基因 ID: 1066 | 基因类型: protein coding

关于 CES1

Cytogenetic location: 16q12.2 Genomic coordinates (GRCh38): 16:55,802,851-55,833,096 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 667 orthologues, 13 paralogues and is associated with 1 phenotype. Biased expression in liver (RPKM 737.7), gall bladder (RPKM 239.9) and 3 other tissues.

功能概要

该基因编码羧酸酯酶大家族的成员。该家族成员负责各种异生素 (如可卡因和海洛因) 以及具有酯、硫酯或酰胺键的内源性底物的水解或酯交换。它们可能参与脂肪酰和胆固醇酯的代谢，并可能在血脑屏障系统中发挥作用。这种酶是主要的肝酶，在肝脏药物清除中发挥作用。该基因的突变导致羧酸酯酶 1 缺乏。已发现该基因编码三种不同亚型的三种转录变体。[RefSeq 提供，2010 年 6 月]

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and Cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

CES1 基因产物(3)

mRNA	Protein	Name
NM_001025194.2	NP_001020365.1	liver carboxylesterase 1 isoform b precursor
NM_001025195.2	NP_001020366.1	liver carboxylesterase 1 isoform a precursor
NM_001266.5	NP_001257.4	liver carboxylesterase 1 isoform c precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables carboxylesterase activity	IDA IDA: 通过直接分析推断	8218228	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA
enables sterol ester esterase activity	IDA IDA: 通过直接分析推断	11015575	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to cholesterol	IMP IMP: 通过突变表型推断	18762277	GOA
involved in cellular response to low-density lipoprotein particle stimulus	IMP IMP: 通过突变表型推断	18762277	GOA
involved in cholesterol biosynthetic process	IDA IDA: 通过直接分析推断	11015575	GOA
involved in cholesterol homeostasis	IMP IMP: 通过突变表型推断	18762277	GOA
involved in cholesterol metabolic process	IDA IDA: 通过直接分析推断	16024911	GOA
involved in epithelial cell differentiation	IDA IDA: 通过直接分析推断	21492153	GOA
involved in medium-chain fatty acid metabolic process	IDA IDA: 通过直接分析推断	11015575	GOA
involved in negative regulation of cholesterol storage	IMP IMP: 通过突变表型推断	16971496	GOA
involved in positive regulation of cholesterol efflux	IMP IMP: 通过突变表型推断	16971496	GOA
involved in positive regulation of cholesterol metabolic process	IMP IMP: 通过突变表型推断	16971496	GOA
involved in regulation of bile acid biosynthetic process	IMP IMP: 通过突变表型推断	18599737	GOA
involved in regulation of bile acid secretion	IMP IMP: 通过突变表型推断	18599737	GOA
involved in reverse cholesterol transport	IMP IMP: 通过突变表型推断	18599737	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	16024911	GOA
located in lipid droplet	IDA IDA: 通过直接分析推断	16024911	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CES1 蛋白结构

COesterase

0
100
200
300
400
500
567 a.a.

蛋白主名

其他名称

liver carboxylesterase 1

acyl coenzyme A:cholesterol acyltransferase

重组 CES1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7730	Carboxylesterase 1 Protein, Human (HEK293, His)	P23141-3 (H19-E562)	≥95%

CES1 抗体

目录号	产品名	应用	反应物种
HY-P82583	Liver Carboxylesterase 1 Antibody (YA2328)	WB, IP, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Drug Metabolism, Altered, Ces1-Related

Egasyn

Esterase 22

Es22

Alveolar Echinococcosis

Echinococcus Multilocularis Infection	Echinococcosis
Alveolococcosis	Multilocular Hydatid
Small Fox Tapeworm

Cystic Echinococcosis

Echinococcus Granulosus Infection	Echinococcus Granulosus Infection Of Lung
Echinococcus Granulosus	Echinococcus Granulosus Infection Of Thyroid
Echinococcus Granulosus Infectious Disease	Echinococcus Granulosus Infectious Disease Of Liver
Echinococcus Granulosus Infectious Disease Of Thyroid	Liver Echinococcus Granulosus
Lung Echinococcus Granulosus	Thyroid Echinococcus Granulosus
Unilocular Echinococcosis	Unilocular Hydatid Disease
Hydatid Disease	Hydatidosis
Echinococcosis

Reye Syndrome

Reye'S Syndrome	Rasmussen Encephalitis
Fatty Liver With Encephalopathy	Rasmussen'S Encephalitis
Re	Rs
Rasmussen Syndrome	Liver Fatty Metamorphosis--Acute Encephalopathy Syndrome
Reye Encephalopathy

Large Intestine Adenoma

Adenoma Of Large Intestine

Polycystic Echinococcosis

Human Polycystic Hydatid Disease

Neotropical Echinococcosis

Echinococcosis

Hydatidosis	Echinococcal Disease
Echinococcosis Of Liver	Hepatic Echinococcosis
Hydatid Disease	Liver Echinococcus
Pulmonary Echinococcosis	Hydatids
Echinococcosis, Hepatic	Echinococcosis, Pulmonary
Unilocular Echinococcosis	Echinococcus Disease
Echinococcus Granulosus Infection	Echinococcus Multilocularis Infection
Dog Tapeworm Infection	Echinococcus Granulosus Infestation
Echinococciasis	Cystic Echinococcosis

Taeniasis

Beef Tapeworm Infection	Infection By Taeniarhynchus Saginatus
Taenia Saginata Infectious Disease	Taenia Saginata Infection
Pork Tapeworm Infection	Armed Tapeworm Infection
Infection By Taenia Solium	Intestinal Taenia Solium Infection
Pork Tapeworm	Taenia Solium Taeniasis
Adult Pork Tapeworm Infection	Adult Pork Tapeworm
Beef Tapeworm	Infection By Taenia Saginata
Unarmed Tapeworm Infection	Taenia Saginata Taeniasis
Infection Due To Adult Tapeworm Taenia Saginata	Mediocanellata Taenia Infection
Infestation By Taenia Saginata	Infestation By Taenia Mediocanellata

Niemann-Pick Disease

Sphingomyelin/Cholesterol Lipidosis	Niemann-Pick Diseases
Lipoid Histiocytosis	Sphingomyelin Lipidosis
Sphingomyelinase Deficiency Disease	Lipid Histiocytosis
Neuronal Cholesterol Lipidosis	Neuronal Lipidosis
Npd	Sphingomyelinase Deficiency
Niemann-Pick Disease, Type A

Retinitis Pigmentosa 44

RP44	Retinitis Pigmentosa, Type 44

Glossopharyngeal Neuralgia

Glossopharyngeal Nerve Diseases

Parasitic Helminthiasis Infectious Disease

Helminthiasis	Intestinal Helminthiasis
Helminth Infection	Helminthosis
Worm Infection	Worm Infections
Helminth Infections	Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata
Parasitic Enteritis	Metazoal Dysentery
Intestinal Worms Nos

Cysticercosis

Neurocysticercosis	Submacular Cysticercosis
Intestinal Taenia Solium Infection	Pork Tapeworm Infection
Tapeworm Infection: Intestinal Taenia Solum	Tapeworm Infection: Pork
Tenia Solium Infectious Disease	Taeniasis
Tenia Solium Infection	Cysticerciasis Infection Due To Larval Form Of Taenia Solium

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-N0921	Dihydromethysticin	Inhibitor	99.94%	否
HY-173267	CES2A-IN-2	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	CES1	VGNC	VGNC:52121
Rattus norvegicus	CES1	RGD	RGD:70896
Mus musculus	CES1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CES1 - carboxylesterase 1 Gene

关于 CES1

功能概要

CES1 基因产物(3)

CES1 蛋白结构

重组 CES1 蛋白

CES1 抗体

关联疾病

直系同源

热门区域

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CES1 - carboxylesterase 1 Gene

关于 CES1

功能概要

CES1 基因产物(3)

CES1 蛋白结构

重组 CES1 蛋白

CES1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z