2. Gene
  3. NFAT5 - nuclear factor of activated T cells 5 Gene

NFAT5 - nuclear factor of activated T cells 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：活化 T 细胞核因子 5

种属: Homo sapiens

同用名: NFATZ; OREBP; NF-AT5; NFATL1; TONEBP

基因 ID: 10725 | 基因类型: protein coding

关于 NFAT5

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:69,565,966-69,704,654 (from NCBI)

This gene has 17 transcripts (splice variants), 279 orthologues, 4 paralogues and is associated with 1 phenotype. Ubiquitous expression in skin (RPKM 6.6), placenta (RPKM 5.9) and 25 other tissues.

功能概要

该基因的产物是活化 T 细胞核因子转录因子家族的成员。属于该家族的蛋白质在免疫反应期间的诱导基因转录中起着核心作用。这种蛋白质调节哺乳动物细胞中渗透压诱导的基因表达。与该蛋白质家族的单体成员不同，该蛋白质以同型二聚体形式存在，并与 DNA 元件形成稳定的二聚体。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

NFAT5 基因产物(7)

mRNA Protein Name
NM_001113178.3 NP_001106649.1 nuclear factor of activated T-cells 5 isoform d
NM_001367709.1 NP_001354638.1 nuclear factor of activated T-cells 5 isoform e
NM_006599.4 NP_006590.1 nuclear factor of activated T-cells 5 isoform c
NM_138713.4 NP_619727.2 nuclear factor of activated T-cells 5 isoform b
NM_138714.4 NP_619728.2 nuclear factor of activated T-cells 5 isoform a
NM_173214.3 NP_775321.1 nuclear factor of activated T-cells 5 isoform a
NM_173215.3 NP_775322.1 nuclear factor of activated T-cells 5 isoform a

NFAT5 蛋白结构

RHD_DNA_bind

RHD_DNA_bind: Rel homology DNA-binding domain (282 - 419)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1531 a.a.
蛋白主名 其他名称

nuclear factor of activated T-cells 5

NFAT-like protein 1

关联疾病

疾病名称 别名
Inflammatory Bowel Disease-Recurrent Sinopulmonary Infections Syndrome

Nfat5 Haploinsufficiency
Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-112125A KRN2 bromide 98.13% 否
HY-112126 KRN5 98.76% 否
HY-112125 KRN2 / 否
HY-12117 L-NIL hydrochloride Inhibitor / 否
HY-RS09237 NFAT5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta NFAT5 VGNC VGNC:75325
Mus musculus NFAT5 MGD MGI:1859333
Bos taurus NFAT5 VGNC VGNC:32029
Canis familiaris NFAT5 VGNC VGNC:43765
Felis catus NFAT5 VGNC VGNC:68468
Rattus norvegicus NFAT5 RGD RGD:1309142
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